Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy

Mario P. Colombo; Silvia Piconese

doi:10.1038/nrc2250

Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy

Nature Reviews Cancer ◽

10.1038/nrc2250 ◽

2007 ◽

Vol 7 (11) ◽

pp. 880-887 ◽

Cited By ~ 254

Author(s):

Mario P. Colombo ◽

Silvia Piconese

Keyword(s):

T Cell ◽

Cancer Immunotherapy ◽

Regulatory T Cell ◽

The Right ◽

Cell Inhibition

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Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy

Journal of Controlled Release ◽

10.1016/j.jconrel.2020.01.015 ◽

2020 ◽

Vol 320 ◽

pp. 168-178 ◽

Cited By ~ 8

Author(s):

Ning Zhang ◽

Shounan Liu ◽

Sanyuan Shi ◽

Yuetan Chen ◽

Fengwei Xu ◽

...

Keyword(s):

T Cell ◽

Tumor Microenvironment ◽

Cancer Immunotherapy ◽

Ursolic Acid ◽

Regulatory T Cell

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Phase I trial of combination of antitumor immunotherapy targeted against cytomegalovirus (CMV) plus regulatory T-cell inhibition in patients with newly-diagnosed glioblastoma multiforme (GBM).

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.e13518 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. e13518-e13518

Author(s):

Gordana Vlahovic ◽

Gerald E. Archer ◽

Elizabeth Reap ◽

Annick Desjardins ◽

Katherine B. Peters ◽

...

Keyword(s):

T Cell ◽

Glioblastoma Multiforme ◽

Phase I ◽

Regulatory T Cell ◽

Phase I Trial ◽

Newly Diagnosed ◽

Antitumor Immunotherapy ◽

Newly Diagnosed Glioblastoma ◽

Cell Inhibition

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CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion

Diabetes ◽

10.2337/db07-1712 ◽

2008 ◽

Vol 57 (10) ◽

pp. 2672-2683 ◽

Cited By ~ 26

Author(s):

M. R. Rigby ◽

A. M. Trexler ◽

T. C. Pearson ◽

C. P. Larsen

Keyword(s):

T Cell ◽

Regulatory T Cell ◽

Cell Expansion ◽

Autoimmune Diabetes ◽

Effector T Cell ◽

T Cell Expansion ◽

Cell Inhibition

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Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression

OncoImmunology ◽

10.4161/21624011.2014.970462 ◽

2014 ◽

Vol 4 (8) ◽

pp. e970462 ◽

Cited By ~ 17

Author(s):

Wendy WJ Unger ◽

Christian T Mayer ◽

Steef Engels ◽

Christina Hesse ◽

Maurizio Perdicchio ◽

...

Keyword(s):

Dendritic Cells ◽

T Cell ◽

Regulatory T Cell ◽

Tumor Regression ◽

Cell Inhibition

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790. Tumor-Specific Viral Inflammation Facilitates Effective Dendritic Cell Cancer Immunotherapy in a Regulatory T Cell-Dependent Manner

Molecular Therapy ◽

10.1016/s1525-0016(16)37363-4 ◽

2011 ◽

Vol 19 ◽

pp. S302

Keyword(s):

T Cell ◽

Dendritic Cell ◽

Cancer Immunotherapy ◽

Regulatory T Cell ◽

Cell Cancer ◽

Dependent Manner

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Abstract 4613: Identification of tumor necrosis factor receptor II as a regulatory T cell target for cancer immunotherapy using designed ankyrin repeat protein phenotypic selections

10.1158/1538-7445.am2014-4613 ◽

2014 ◽

Author(s):

Geoff Williams ◽

Judith Anderton ◽

Vahe Bedian ◽

Jane Coates Ulrichsen ◽

Andrea Gonzalez-Munoz ◽

...

Keyword(s):

T Cell ◽

Tumor Necrosis Factor ◽

Cancer Immunotherapy ◽

Regulatory T Cell ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Receptor ◽

Ankyrin Repeat ◽

Ankyrin Repeat Protein ◽

Cell Target ◽

Necrosis Factor

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Abstract 1608: CD122-selective IL-2/anti-IL-2 complexes reduce regulatory T cell function and promote CD8+T cell polyfunctionality for durable ovarian cancer immunotherapy

10.1158/1538-7445.am2017-1608 ◽

2017 ◽

Author(s):

Justin M. Drerup ◽

Sri Lakshmi Pandeswara ◽

Aijie Liu ◽

Curtis A. Clark ◽

Alvaro S. Padron ◽

...

Keyword(s):

Ovarian Cancer ◽

T Cell ◽

Cancer Immunotherapy ◽

Regulatory T Cell ◽

Cell Function ◽

Cd8 T Cell ◽

T Cell Function

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Phosphoinositide 3‐kinase δis a regulatory T‐cell target in cancer immunotherapy

Immunology ◽

10.1111/imm.13082 ◽

2019 ◽

Vol 157 (3) ◽

pp. 210-218 ◽

Cited By ~ 10

Author(s):

Ee Lyn Lim ◽

Klaus Okkenhaug

Keyword(s):

T Cell ◽

Cancer Immunotherapy ◽

Regulatory T Cell ◽

Cell Target ◽

Phosphoinositide 3 Kinase

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Mechanisms of T-cell inhibition: implications for cancer immunotherapy

Expert Review of Vaccines ◽

10.1586/erv.09.144 ◽

2010 ◽

Vol 9 (1) ◽

pp. 89-105 ◽

Cited By ~ 16

Author(s):

Elizabeth A Mittendorf ◽

Padmanee Sharma

Keyword(s):

T Cell ◽

Cancer Immunotherapy ◽

Cell Inhibition

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Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-13-1016 ◽

2013 ◽

Vol 20 (1) ◽

pp. 131-139 ◽

Cited By ~ 69

Author(s):

Serena K. Perna ◽

Daria Pagliara ◽

Aruna Mahendravada ◽

Hao Liu ◽

Malcolm K. Brenner ◽

...

Keyword(s):

T Cell ◽

T Lymphocytes ◽

Cytotoxic T Lymphocytes ◽

Regulatory T Cell ◽

Interleukin 7 ◽

Cell Inhibition

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