Memory NK cells identified in primates

2015 ◽  
Vol 15 (9) ◽  
pp. 527-527
Author(s):  
Joana Osorio
Keyword(s):  
Nk Cells ◽  
Memory Nk Cells

scholarly journals HIV-1-induced cytokines deplete homeostatic ILCs and expand TCF7-dependent memory NK cells: Supplemental Figures and Tables

2017 ◽  
Author(s):  
Yetao Wang ◽  
Kyle Gellatly ◽  
Sean McCauley ◽  
Pranitha Vangala ◽  
Kyusik Kim ◽  
...  
Keyword(s):  
Nk Cells ◽  
Inflammatory Cytokines ◽  
Nk Cell ◽  
Ex Vivo ◽  
Developmental Trajectory ◽  
Lymphoid Cells ◽  
Infected People ◽  
Cell Induction ◽  
Hiv 1 ◽  
Memory Nk Cells

HIV-1-infected people who take medications that suppress viremia, preserve CD4+ T cells, and prevent AIDS, have chronic inflammation with increased cardiovascular mortality. To investigate the etiology of this inflammation, the effect of HIV-1 on innate lymphoid cells (ILCs) and NK cells was examined. Homeostatic ILCs in blood and intestine were depleted permanently. NK cells were skewed towards a memory subset. Cytokines that are elevated during HIV-1 infection reproduced both abnormalities ex vivo. Pseudotime analysis of single NK cell transcriptomes revealed a developmental trajectory towards a subset with expression profile, chromatin state, and biological function like memory T lymphocytes. Expression of TCF7, a WNT transcription factor, increased over the course of the trajectory. TCF7 disruption, or WNT inhibition, prevented memory NK cell induction by inflammatory cytokines. These results demonstrate that inflammatory cytokines associated with HIV-1 infection irreversibly disrupt homeostatic ILCs and cause developmental shift towards TCF7+ memory NK cells.

scholarly journals Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells

2018 ◽  
Vol 200 (6) ◽  
pp. 1977-1981 ◽  
Author(s):  
Sharline Madera ◽  
Clair D. Geary ◽  
Colleen M. Lau ◽  
Olga Pikovskaya ◽  
Steven L. Reiner ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Nk Cells ◽  
Cutting Edge ◽  
T Box ◽  
Memory Nk Cells

scholarly journals Memory NK Cells Take Out the (Mitochondrial) Garbage

Immunity ◽  
2015 ◽  
Vol 43 (2) ◽  
pp. 218-220 ◽  
Author(s):  
Julia A. Wagner ◽  
Todd A. Fehniger
Keyword(s):  
Nk Cells ◽  
Memory Nk Cells

scholarly journals Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection

2016 ◽  
Vol 213 (12) ◽  
pp. 2745-2758 ◽  
Author(s):  
Tsukasa Nabekura ◽  
Lewis L. Lanier
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Interleukin 12 ◽  
Mcmv Infection ◽  
Specific Memory ◽  
Important Host ◽  
Free Environment ◽  
Memory Nk Cells

Natural killer (NK) cells provide important host defense and can generate long-lived memory NK cells. Here, by using novel transgenic mice carrying inducible Cre expressed under the control of Ncr1 gene, we demonstrated that two distinct long-lived NK cell subsets differentiate in a mouse model of cytomegalovirus (MCMV) infection. NK cells expressing the MCMV-specific Ly49H receptor differentiated into memory NK cells by an activating signaling through Ly49H and Ly49H− NK cells differentiated into cytokine-activated NK cells by exposure to inflammatory cytokines during infection. Interleukin-12 is indispensable for optimal generation of both antigen-specific memory NK cells and cytokine-activated NK cells. MCMV-specific memory NK cells show enhanced effector function and augmented antitumor activity in vivo as compared with cytokine-activated NK cells, whereas cytokine-activated NK cells exhibited a more robust response to IL-15 and persisted better in an MCMV-free environment. These findings reveal that NK cells are capable of differentiation into distinct long-lived subsets with different functional properties.

scholarly journals Identifying SARS‐CoV‐2 “memory” NK cells from COVID‐19 convalescent donors for adoptive cell therapy

Immunology ◽  
2021 ◽  
Author(s):  
Lara Herrera ◽  
Myriam Martin‐Inaraja ◽  
Silvia Santos ◽  
Marta Inglés‐Ferrándiz ◽  
Aida Azkarate ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Nk Cells ◽  
Adoptive Cell Therapy ◽  
Memory Nk Cells

scholarly journals Proinflammatory cytokine signaling required for the generation of natural killer cell memory

2012 ◽  
Vol 209 (5) ◽  
pp. 947-954 ◽  
Author(s):  
Joseph C. Sun ◽  
Sharline Madera ◽  
Natalie A. Bezman ◽  
Joshua N. Beilke ◽  
Mark H. Kaplan ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cell ◽  
Interleukin 12 ◽  
Cytokine Signaling ◽  
Mcmv Infection ◽  
Ifn Γ ◽  
Deficient Mice ◽  
Memory Nk Cells

Although natural killer (NK) cells are classified as innate immune cells, recent studies demonstrate that NK cells can become long-lived memory cells and contribute to secondary immune responses. The precise signals that promote generation of long-lived memory NK cells are unknown. Using cytokine receptor-deficient mice, we show that interleukin-12 (IL-12) is indispensible for mouse cytomegalovirus (MCMV)-specific NK cell expansion and generation of memory NK cells. In contrast to wild-type NK cells that proliferated robustly and resided in lymphoid and nonlymphoid tissues for months after MCMV infection, IL-12 receptor–deficient NK cells failed to expand and were unable to mediate protection after MCMV challenge. We further demonstrate that a STAT4-dependent IFN-γ–independent mechanism contributes toward the generation of memory NK cells during MCMV infection. Understanding the full contribution of inflammatory cytokine signaling to the NK cell response against viral infection will be of interest for the development of vaccines and therapeutics.

scholarly journals Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection

2014 ◽  
Vol 211 (13) ◽  
pp. 2669-2680 ◽  
Author(s):  
Gundula Min-Oo ◽  
Lewis L. Lanier
Keyword(s):  
Nk Cells ◽  
Host Response ◽  
Ex Vivo ◽  
Specific Response ◽  
Type I ◽  
Secondary Challenge ◽  
Acute Viral Infection ◽  
Ifn Γ ◽  
Systemic Bacterial Infection ◽  
Memory Nk Cells

Natural killer (NK) cells play a key role in the host response to cytomegalovirus (CMV) and can mediate an enhanced response to secondary challenge with CMV. We assessed the ability of mouse CMV (MCMV)–induced memory Ly49H+ NK cells to respond to challenges with influenza, an acute viral infection localized to the lung, and Listeria monocytogenes, a systemic bacterial infection. MCMV-memory NK cells did not display enhanced activation or proliferation after infection with influenza or Listeria, as compared with naive Ly49H+ or Ly49H− NK cells. Memory NK cells also showed impaired activation compared with naive cells when challenged with a mutant MCMV lacking m157, highlighting their antigen-specific response. Ex vivo, MCMV-memory NK cells displayed reduced phosphorylation of STAT4 and STAT1 in response to stimulation by IL-12 and type I interferon (IFN), respectively, and IFN-γ production was reduced in response to IL-12 + IL-18 compared with naive NK cells. However, costimulation of MCMV-memory NK cells with IL-12 and m157 antigen rescues their impaired response compared with cytokines alone. These findings reveal that MCMV-primed memory NK cells are diminished in their response to cytokine-driven bystander responses to heterologous infections as they become specialized and antigen-specific for the control of MCMV upon rechallenge.

scholarly journals Phenotypic and functional characteristics of a novel influenza hemagglutinin-specific memory NK cell

2021 ◽  
Author(s):  
Jian Zheng ◽  
Liyan Wen ◽  
Hui-Ling Yen ◽  
Ming Liu ◽  
Yinping Liu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Nk Cells ◽  
Nk Cell ◽  
Cell Subset ◽  
Influenza Virus Infection ◽  
Immune Memory ◽  
Influenza Hemagglutinin ◽  
Ifn Γ ◽  
Memory Nk Cells

Immune memory represents the most efficient defense against invasion and transmission of infectious pathogens. In contrast to memory T and B cells, the roles of innate immunity in recall responses remain inconclusive. In this study, we identified a novel mouse spleen NK cell subset expressing NKp46 and NKG2A induced by intranasal influenza virus infection. These memory NK cells specifically recognize N-linked glycosylation sites on influenza hemagglutinin (HA) protein. Different from memory-like NK cells reported previously, these NKp46+NKG2A+ memory NK cells exhibited HA-specific silence of cytotoxicity but increase of IFN-γ response against influenza virus-infected cells, which could be reversed by Pifithrin-μ, a p53-HSP70 signaling inhibitor. During recall responses, splenic NKp46+NKG2A+ NK cells were recruited to infected lung and modulated viral clearance of virus and CD8+ T cell distribution, resulting in improved clinical outcomes. This long-lived NK memory bridges innate and adaptive immune memory response and promotes the homeostasis of local environment during recall response. Importance In this study, we demonstrate a novel HA-specific NKp46+NKG2A+ NK cell subset induced by influenza A virus infection. These memory NK cells show virus-specific decreased cytotoxicity and increased IFN-γ on re-encountering the same influenza virus antigen. In addition, they modulate host recall responses and CD8 T cell distribution, thus bridging the innate immune and adaptive immune responses during influenza virus infection.

scholarly journals HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells

2020 ◽  
Vol 21 (3) ◽  
pp. 274-286 ◽  
Author(s):  
Yetao Wang ◽  
Lawrence Lifshitz ◽  
Kyle Gellatly ◽  
Carol L. Vinton ◽  
Kathleen Busman-Sahay ◽  
...  
Keyword(s):  
Nk Cells ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Hiv 1 ◽  
Memory Nk Cells
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