Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study

Background. Most research has indicated that neuroticism (or trait anxiety) is associated with only negative outcomes. Such a common, heritable and variable trait is expected to have beneficial as well as detrimental effects. We tested the hypothesis that trait anxiety in childhood reduces the risk of dying from accidental causes in early adult life.Method. A longitudinal, population-based, birth cohort study of 4070 men and women born in the UK in 1946. Trait anxiety as judged by teachers when the participants were 13 and 15 years old, and the neuroticism scale of a Maudsley Personality Inventory (MPI) when the participants were 16 years old. Outcomes were deaths, deaths from accidents, non-fatal accidents, and non-fatal accidents requiring medical intervention.Results. Adolescents with low trait anxiety had higher rates of accident mortality to age 25 [low anxiety at 13, hazard ratio (HR) 5·9, low anxiety at 15, HR 1·8]. Low trait anxiety in adolescence was associated with decreased non-accidental mortality after age 25 (low anxiety at 13, HR 0; low anxiety at 15, HR 0·7; low neuroticism at 16, HR 0·7).Conclusions. High trait anxiety measured in adolescence is associated with reduced accidents and accidental death in early adulthood but higher rates of non-accidental mortality in later life.

Download Full-text

Risk of primary gastrointestinal cancers following incident non-metastatic breast cancer: a Danish population-based cohort study

BMJ Open Gastroenterology ◽

10.1136/bmjgast-2020-000413 ◽

2020 ◽

Vol 7 (1) ◽

pp. e000413

Author(s):

Kasper Adelborg ◽

Dóra Körmendiné Farkas ◽

Jens Sundbøll ◽

Lidia Schapira ◽

Suzanne Tamang ◽

...

Keyword(s):

Breast Cancer ◽

Colon Cancer ◽

Cohort Study ◽

Metastatic Breast Cancer ◽

Stomach Cancer ◽

Metastatic Breast ◽

Population Based ◽

Gastrointestinal Cancers ◽

Increased Risk

ObjectiveWe examined the risk of primary gastrointestinal cancers in women with breast cancer and compared this risk with that of the general population.DesignUsing population-based Danish registries, we conducted a cohort study of women with incident non-metastatic breast cancer (1990–2017). We computed cumulative cancer incidences and standardised incidence ratios (SIRs).ResultsAmong 84 972 patients with breast cancer, we observed 2340 gastrointestinal cancers. After 20 years of follow-up, the cumulative incidence of gastrointestinal cancers was 4%, driven mainly by colon cancers. Only risk of stomach cancer was continually increased beyond 1 year following breast cancer. The SIR for colon cancer was neutral during 2–5 years of follow-up and approximately 1.2-fold increased thereafter. For cancer of the oesophagus, the SIR was increased only during 6–10 years. There was a weak association with pancreas cancer beyond 10 years. Between 1990–2006 and 2007–2017, the 1–10 years SIR estimate decreased and reached unity for upper gastrointestinal cancers (oesophagus, stomach, and small intestine). For lower gastrointestinal cancers (colon, rectum, and anal canal), the SIR estimate was increased only after 2007. No temporal effects were observed for the remaining gastrointestinal cancers. Treatment effects were negligible.ConclusionBreast cancer survivors were at increased risk of oesophagus and stomach cancer, but only before 2007. The risk of colon cancer was increased, but only after 2007.

Download Full-text

Incidence of venous thromboembolic events in enhanced recovery after surgery for colon cancer: a retrospective, population-based cohort study

Colorectal Disease ◽

10.1111/codi.13910 ◽

2017 ◽

Vol 19 (11) ◽

pp. O393-O401 ◽

Cited By ~ 9

Author(s):

M. M. I. Vendler ◽

T. A. Haidari ◽

J. E. Waage ◽

J. Kleif ◽

B. Kristensen ◽

...

Keyword(s):

Colon Cancer ◽

Cohort Study ◽

Enhanced Recovery ◽

Enhanced Recovery After Surgery ◽

Population Based ◽

Thromboembolic Events ◽

Venous Thromboembolic Events ◽

Venous Thromboembolic

Download Full-text

Survival outcomes for right-versus left-sided colon cancer and rectal cancer in England: A propensity-score matched population-based cohort study

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2021.10.007 ◽

2021 ◽

Author(s):

Nicola Hodges ◽

Hugh Mackenzie ◽

Nigel D'Souza ◽

Gina Brown ◽

Danilo Miskovic

Keyword(s):

Rectal Cancer ◽

Colon Cancer ◽

Cohort Study ◽

Propensity Score ◽

Population Based ◽

Survival Outcomes

Download Full-text

Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study

British Journal of Cancer ◽

10.1038/bjc.2017.139 ◽

2017 ◽

Vol 116 (12) ◽

pp. 1652-1659 ◽

Cited By ~ 15

Author(s):

Ronan T Gray ◽

Maurice B Loughrey ◽

Peter Bankhead ◽

Chris R Cardwell ◽

Stephen McQuaid ◽

...

Keyword(s):

Colon Cancer ◽

Cohort Study ◽

Cancer Survival ◽

Mevalonate Pathway ◽

Population Based ◽

Statin Use

Download Full-text

No association between colon cancer and adenocarcinoma of the oesophagus in a population based cohort study in Sweden

Gut ◽

10.1136/gut.44.6.819 ◽

1999 ◽

Vol 44 (6) ◽

pp. 819-821 ◽

Cited By ~ 15

Author(s):

J Lagergren ◽

O Nyren

Keyword(s):

Colon Cancer ◽

Cohort Study ◽

Relative Risk ◽

Population Based ◽

Oesophageal Adenocarcinoma ◽

Expected Number ◽

Colonic Neoplasia ◽

Barrett's Metaplasia ◽

Barrett’S Metaplasia

BACKGROUNDPrevious reports have indicated an association between Barrett’s metaplasia or adenocarcinoma of the oesophagus and colonic neoplasia, but the findings have been inconsistent. If true, such an association suggests common causal mechanisms.AIMSTo test the hypothesis of an association between Barrett’s metaplasia or adenocarcinoma of the oesophagus and colonic neoplasia.METHODSA population based, retrospective cohort study was performed on all Swedish patients with colon cancer diagnosed between 1958 and 1992. 538 500 person years at risk were reviewed among the 118 030 patients in the cohort (average follow up 4.6 years, median 2.1 years). The standardised incidence ratio (SIR), the ratio of the observed to the expected number of incident oesophageal adenocarcinomas, was used as a measure of relative risk. The expected number was derived from the entire Swedish population.RESULTSEleven oesophageal adenocarcinomas were found during follow up in the cohort, as against 9.5 expected (SIR=1.2; 95% confidence interval 0.6–2.1). Analysis by latency intervals after diagnosis of colon cancer showed no trend towards increasing or decreasing risk over time. There were no important sex differences in relative risk.CONCLUSIONSResults provide no support for a common link between colon cancer and oesophageal adenocarcinoma. Although the direct relation between colon cancer and Barrett’s oesophagus was not looked at, a search for common aetiological factors or genetic defects may not be fruitful. Screening for colonic neoplasia among patients with malignant or premalignant oesophageal mucosa, or vice versa, may not be warranted.

Download Full-text

Predictors of early adulthood hypertension during adolescence: a population-based cohort study

BMC Public Health ◽

10.1186/s12889-017-4922-3 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 11

Author(s):

Saeed Kalantari ◽

Davood Khalili ◽

Samaneh Asgari ◽

Noushin Fahimfar ◽

Farzad Hadaegh ◽

...

Keyword(s):

Cohort Study ◽

Early Adulthood ◽

Population Based

Download Full-text

Long‐term survival following elective colon cancer surgery in the aged. A population‐based cohort study

Colorectal Disease ◽

10.1111/codi.15242 ◽

2020 ◽

Vol 22 (11) ◽

pp. 1585-1596

Author(s):

S. Niemeläinen ◽

H. Huhtala ◽

A. Ehrlich ◽

J. Kössi ◽

E. Jämsen ◽

...

Keyword(s):

Colon Cancer ◽

Cohort Study ◽

Population Based ◽

Cancer Surgery ◽

Term Survival ◽

Long Term Survival ◽

Colon Cancer Surgery ◽

Elective Colon

Download Full-text

Association of delayed commencement of adjuvant chemotherapy (AC) with inferior survival in colon cancer patients with stage II and III diseases: A national population-based cohort study.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.4_suppl.669 ◽

2017 ◽

Vol 35 (4_suppl) ◽

pp. 669-669

Author(s):

Ik Yong Kim ◽

Young Wan Kim

Keyword(s):

Colon Cancer ◽

Cohort Study ◽

Health Insurance ◽

Emergency Surgery ◽

Cancer Care ◽

Population Based ◽

Older Age ◽

Stage Ii ◽

Chemotherapy Group ◽

Colon Cancer Care

669 Background: To evaluate factors affecting the delay ( ≥ 8 weeks) of AC and the impact of chemotherapy delay on survival in patients with colon cancer(CC). Methods: The study cohort consisted of patients with stage II and III colon cancer, diagnosed between January 1, 2011 and December 31, 2012, who underwent curative resection and AC at all hospitals registered in the Korean Health Insurance Review and Assessment Service (HIRA). Detailed clinical data are from monitoring and evaluation of quality of colon cancer care. Results: Among 5355 patients, 154 (2.9%) received AC more than 8 weeks after surgery. Based on multivariate analysis, risk factors associated with AC delay ≥ 8 weeks were: older age [65 to 74 years (hazard ratio, HR = 1.48) and 75 years (HR = 1.69), p = 0.0354], medical aid status in health security system (HR = 1.76, p = 0.0345), emergency surgery (HR = 2.43, p = 0.0002), and chemotherapy with fluoropyrimidine (HR = 1.49, p = 0.0373). Independent prognostic factors for inferior OS included AC delay ≥ 8 weeks (HR = 1.49, p = 0.0365), older age [65 to 74 years (HR = 1.94) and 75 years (HR = 3.41), p < 0.0001], TNM III stage (HR = 2.46, p < 0.0001), emergency surgery (HR = 1.89, p < 0.0001), ASA score with 3 or higher (HR = 1.50, p < 0.0001), and higher transfusion amount (HR = 1.09, p = 0.0392). OS rates in patients with stage II / III CCs according to delay of AC using 8 weeks cutoff showed inferior OS in the delayed chemotherapy group (p = 0.008).Detailed OS rates were 97.81% at 1 year, 93.77% at 2 year, 89.62% at 3 year, and 85.79% at 4 year in the chemotherapy group within 8weeks. In the delayed chemotherapy group ≥ 8 weeks, OS rates were 96.1% at 1 year, 87.66% at 2 year, 80.98% at 3 year, and 80.2% at 4 year. Conclusions: This national population-based cohort study shows that delayed commencement of AC, defined as ≥ 8 weeks, is associated with inferior OS in CC patients with stage II / III. To reduce the proportion of patients receiving delayed AC, multidimensional aspects such as health insurance status or age should be considered. Based on our results, the time of commencement of chemotherapy can be incorporated as another quality indicator for colon cancer care.

Download Full-text