Hematological manifestations of Good syndrome

In patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively analyzed medical records of consecutive patients that were diagnosed with acute hepatitis E (AHE) (n = 69) or acute hepatitis A (AHA) (n = 46) at the University Medical Center Hamburg Eppendorf from January 2009 to August 2019 for demographical, clinical, and laboratory information. Patients with AHE had significantly lower median levels of ALAT (798 U/L) and total bilirubin (1.8 mg/dL) compared to patients with AHA (2326 U/L; p < 0.001 and 5.2 mg/dL; p < 0.001), suggesting a generally less severe hepatitis. In contrast, patients with AHE had significantly higher median serum creatinine levels (0.9 mg/dL vs. 0.8 mg/dL; p = 0.002) and lower median estimated glomerular filtration rate (eGFR) (91 mL/min/1.73 m2 vs. 109 mL/min/1.73 m2; p < 0.001) than patients with AHA. Leucocyte, neutrophil and lymphocyte count, hemoglobin, platelets, red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and RDW to lymphocyte ratio (RLR) did not differ between patients with AHE and those with AHA. Our observations indicate that renal but not hematological interference presents an underrecognized extrahepatic feature of AHE, while inflammation of the liver seems to be more severe in AHA.

Download Full-text

Two Independent Hematological malignancies in a B-Cell Deficient Good Syndrome Patient

Rheumatology ◽

10.1093/rheumatology/keaa666 ◽

2020 ◽

Author(s):

Marvyn T Koning ◽

André P van Rossum ◽

Nicolette L Tiren-Verbeet ◽

Jacobus A Burgers ◽

A Faiz Karim

Keyword(s):

B Cell ◽

Hematological Malignancies ◽

Syndrome Patient ◽

Good Syndrome

Download Full-text

A surgical case of Good syndrome accompanied by respiratory tract infections and diarrhea

The Journal of the Japanese Association for Chest Surgery ◽

10.2995/jacsurg.33.566 ◽

2019 ◽

Vol 33 (5) ◽

pp. 566-572

Author(s):

Kenshiro Omura ◽

Masahiro Kaji ◽

Shoji Kuriyama ◽

Saeko Takahashi ◽

Shigemichi Hirose ◽

...

Keyword(s):

Respiratory Tract ◽

Respiratory Tract Infections ◽

Surgical Case ◽

Good Syndrome ◽

Tract Infections

Download Full-text

Lupus-related vasculitis in a cohort of systemic lupus erythematosus patients

Archives of Rheumatology ◽

10.46497/archrheumatol.2021.8804 ◽

2021 ◽

Vol 36 (4) ◽

pp. 595-692

Author(s):

Sherif M Gamal ◽

Sally S. Mohamed ◽

Marwa Tantawy ◽

Ibrahem Siam ◽

Ahmed Soliman ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Disease Duration ◽

Laboratory Data ◽

Disease Onset ◽

Damage Index ◽

Livedo Reticularis ◽

Treatment Modalities ◽

Systemic Lupus ◽

Hematological Manifestations

Objectives: This study aims to examine the frequency and clinical association of lupus-related vasculitis in patients with systemic lupus erythematosus (SLE). Patients and methods: We retrospectively analyzed medical records of a total of 565 SLE patients (42 males, 523 females; mean age: 32.7±9.5 years; range, 13 to 63 years) between January 2017 and February 2020. Demographic, clinical data, and laboratory data and treatment modalities applied were recorded. Lupus-related vasculitis and its different types were documented, and the patients with vasculitis were compared with those without vasculitis. Results: The mean disease duration was 8.9±6.3 years. Vasculitis associated with lupus was found in 191 (33.45%) patients. Cutaneous vasculitis was found in 59.2%, visceral vasculitis in 34.0%, and both in 6.8% of total vasculitis patients. The patients with vasculitis had a longer disease duration (p=0.01), were more likely to have juvenile onset (p=0.002), livedo reticularis (p<0.001), Raynaud's phenomenon (RP) (p<0.001), digital gangrene (p<0.001), thrombosis (p=0.003), and cranial neuropathy (p=0.004). The patients with vasculitis showed a higher prevalence of hypercholesterolemia (p=0.045), diabetes mellitus (p=0.026), higher Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) at disease onset (p<0.001), and Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (p=0.003) scores. They had more prevalent hematological manifestations (p<0.001), hypocomplementemia (p=0.007), received a higher cumulative dose of intravenous methylprednisolone (p<0.001), and had also more frequent cyclophosphamide (p=0.016) and azathioprine intake (p<0.001). In the logistic regression analysis, SLE vasculitis was independently associated with juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher scores of SLEDAI at disease onset (p<0.05). Conclusion: Juvenile disease onset, livedo reticularis, RP, hematological manifestations, and higher SLEDAI scores at disease onset may be associated with the development of vasculitis in SLE patients.

Download Full-text

Genetic diversity of Ehrlichia canisstrains from naturally infected dogs in Rio de Janeiro, Brazil

Revista Brasileira de Parasitologia Veterinária ◽

10.1590/s1984-29612014055 ◽

2014 ◽

Vol 23 (3) ◽

pp. 301-308 ◽

Cited By ~ 8

Author(s):

Renata Fernandes Ferreira ◽

Aloysio de Mello Figueiredo Cerqueira ◽

Tatiana Xavier de Castro ◽

Eliane de Oliveira Ferreira ◽

Felipe Piedade Gonçalves Neves ◽

...

Keyword(s):

Genetic Diversity ◽

Rio De Janeiro ◽

Complete Sequence ◽

Rrna Gene ◽

Hybrid Strain ◽

The Us ◽

Polymerase Chain ◽

Hematological Manifestations ◽

Pcr Targeting ◽

The 16S Rrna Gene

The aim of this study was to characterize Ehrlichia canis strains from naturally infected dogs in Rio de Janeiro, Brazil. In addition, all the clinical and hematological findings observed in these dogs were reported. PCR targeting the 16S rRNA gene was used for diagnostic purposes, and the TRP19 and TRP36 genes were sequenced to evaluate the genetic diversity. Fifteen samples were positive for E. canis. The polymerase chain reaction for the TRP19 gene resulted in 11 amplicons (11/15), which were cloned into the pGEM-T easy vector for sequencing. The complete sequence of TRP19 gene was compared to those in the GenBank, revealing high identicalness. Phylogenetic analysis on the TRP36 gene sequences demonstrated two distinct strains from two dogs, named 56C and 70C. The 56C strain was grouped with the strain Cuiaba 16, which is a hybrid strain formed by Brazilian and US genogroups; and the 70C strain was grouped with other strains of the US genogroup, thus suggesting that there are at least two genogroups of E. canis in Rio de Janeiro (US and Brazilian). Those animals, in which the 70C and 56C strains were isolated, showed distinct clinical and hematological manifestations of 1the disease. The appearance of different genotypes may express new phenotypes, thus resulting in different forms of presentation of the disease and making its diagnosis more complex.

Download Full-text

Agranulocytosis and Good Syndrome in Patient with Thymoma—The Role of Immunosuppressive Treatment after Thymectomy

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.04.037 ◽

2018 ◽

Vol 13 (9) ◽

pp. e177-e178

Author(s):

Olivera Markovic ◽

Natasa Colakovic ◽

Dragomir Marisavljevic

Keyword(s):

Immunosuppressive Treatment ◽

Good Syndrome

Download Full-text

Prevention of infectious diseases in patients with Good syndrome

Current Opinion in Infectious Diseases ◽

10.1097/qco.0000000000000473 ◽

2018 ◽

Vol 31 (4) ◽

pp. 267-277 ◽

Cited By ~ 3

Author(s):

Ashrit Multani ◽

Carlos A. Gomez ◽

José G. Montoya

Keyword(s):

Infectious Diseases ◽

Good Syndrome

Download Full-text

Good syndrome with cytomegalovirus hepatitis: successful resection of Thymoma: a case report

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-020-01187-y ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Sho Isobe ◽

Atsushi Sano ◽

Hajime Otsuka ◽

Yoko Azuma ◽

Satoshi Koezuka ◽

...

Keyword(s):

Case Report ◽

Good Syndrome ◽

Cytomegalovirus Hepatitis

Download Full-text

Hematological Manifestations among Patients with Rheumatic Diseases

Acta Haematologica ◽

10.1159/000511759 ◽

2020 ◽

pp. 1-10

Author(s):

Alina Klein ◽

Yair Molad

Keyword(s):

Rheumatic Diseases ◽

Lupus Erythematosus ◽

Scleroderma Renal Crisis ◽

Thrombotic Microangiopathies ◽

Timely Manner ◽

Antirheumatic Drugs ◽

Catastrophic Antiphospholipid Syndrome ◽

Hematological Disorders ◽

Hematological Abnormalities ◽

Hematological Manifestations

Background: Rheumatic diseases have many hematological manifestations. Blood dyscrasias and other hematological abnormalities are sometimes the first sign of rheumatic disease. In addition, novel antirheumatic biological agents may cause cytopenias. Summary: The aim of this review was to discuss cytopenias caused by systemic lupus erythematosus and antirheumatic drugs, Felty’s syndrome in rheumatoid arthritis, and autoimmune hemolytic anemia, thrombosis, and thrombotic microangiopathies related to rheumatological conditions such as catastrophic antiphospholipid syndrome and scleroderma renal crisis. Key Message: The differential diagnosis of various hematological disorders should include rheumatic autoimmune diseases among other causes of blood cell and hemostasis abnormalities. It is crucial that hematologists be aware of these presentations so that they are diagnosed and treated in a timely manner.

Download Full-text