Comparison of triblock copolymeric micelles based on α- and ε-poly(L-lysine): a Cornelian choice

AbstractDue to the lack of safe carriers for the delivery of small interfering RNA (siRNA), clinical applications of nucleotide-based therapeutics have been limited. In this study, biodegradable amphiphilic triblock copolymers with tailored molecular weights for each block composed of methoxy poly(ethylene glycol) (2000 g/mol), poly(L-lysine) (1300 g/mol) and poly(D,L-lactic acid) (1800 g/mol) (mPEG45-α-PLL10-PLA25) were synthesized and fully characterized. The peptide synthesis was carried out on a solid phase to limit the presence of cationic charges. The arrangement and availability of cationic amino groups within a micellar vector were investigated to determine the colloidal stability as well as the predisposition of these systems to vectorize siRNAs in addition to their already known ability to improve the solubility of hydrophobic compounds. For this purpose, a triblock copolymer containing an epsilon poly(L-lysine) was synthesized similarly. Accordingly, the arrangement of the cationic segment modifies the rigidity involving a complexation constraint due to limited cationic charges available on the surface, which can compromise the efficiency of delivery into cells. In addition, the two vectors were biocompatible in different human cell lines.

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Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽

10.1039/c4ra12255k ◽

2015 ◽

Vol 5 (26) ◽

pp. 20025-20034 ◽

Cited By ~ 17

Author(s):

Yuling Li ◽

Sai Wang ◽

Dandan Zhu ◽

Yuling Shen ◽

Baixiang Du ◽

...

Keyword(s):

Amino Acid ◽

Drug Release ◽

Ethylene Glycol ◽

Lipoic Acid ◽

Triblock Copolymer ◽

Intracellular Delivery ◽

Poly Ethylene Glycol ◽

Copolymer Micelles ◽

Poly Ethylene ◽

Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

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Differential scanning calorimetry studies on poly(ethylene glycol) with different molecular weights for thermal energy storage materials

Polymers for Advanced Technologies ◽

10.1002/pat.276 ◽

2002 ◽

Vol 13 (10-12) ◽

pp. 690-696 ◽

Cited By ~ 185

Author(s):

Krzysztof Pielichowski ◽

Kinga Flejtuch

Keyword(s):

Differential Scanning Calorimetry ◽

Energy Storage ◽

Ethylene Glycol ◽

Thermal Energy ◽

Thermal Energy Storage ◽

Energy Storage Materials ◽

Poly Ethylene Glycol ◽

Scanning Calorimetry ◽

Molecular Weights ◽

Poly Ethylene

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Preparation of thermo-responsive drug carrier consisting of biocompatible triblock copolymer and fullerene

Journal of Materials Chemistry B ◽

10.1039/d1tb02183d ◽

2021 ◽

Author(s):

Kohei Kitano ◽

Kazuhiko Ishihara ◽

Shinichi Yusa

Keyword(s):

Ethylene Glycol ◽

Radical Polymerization ◽

Triblock Copolymer ◽

Drug Carrier ◽

Controlled Radical Polymerization ◽

Poly Ethylene Glycol ◽

Poly Ethylene

A triblock copolymer (PEG-b-PUEM-b-PMPC; EUM) comprising poly(ethylene glycol) (PEG), thermo-responsive poly(2-ureidoethyl methacrylate) (PUEM), and poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC) blocks was synthesized via controlled radical polymerization. PEG and PMPC blocks exhibit hydrophilicity...

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Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications

Polymer Bulletin ◽

10.1007/s00289-016-1791-3 ◽

2016 ◽

Vol 74 (5) ◽

pp. 1595-1609 ◽

Cited By ~ 4

Author(s):

Ngoc Ha Hoang ◽

Chaemin Lim ◽

Taehoon Sim ◽

Eun Seong Lee ◽

Yu Seok Youn ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Anticancer Drug ◽

Triblock Copolymer ◽

Poly Ethylene Glycol ◽

Anticancer Drug Delivery ◽

Drug Delivery Applications ◽

Poly Ethylene ◽

Copolymer Poly

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Testing the Performance of Various Polymeric Antiscalants for Mitigation of Sb-Rich Precipitates Mimicking Stibnite-Based Geothermal Deposits

Geofluids ◽

10.1155/2020/8867084 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Celal Çiftçi ◽

Emre Karaburun ◽

Serhat Tonkul ◽

Alper Baba ◽

Mustafa M. Demir ◽

...

Keyword(s):

Power Plants ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Poly Ethylene Glycol ◽

Molecular Weights ◽

Geothermal Fields ◽

The World ◽

Testing Potential ◽

Poly Ethylene ◽

Poly Vinyl Pyrrolidone

Scaling is frequently observed in geothermal fields and reduces the energy harvesting of power plants. Recently, Sb-rich deposits have developed in many fields around the world. Various polymeric macromolecules have been used as antiscalants to mitigate the formation of scale. Testing potential commercial antiscalants in field conditions is a tedious and costly process. The artificial synthesis of geothermal deposits in the lab is a more practical and economical way to test the performance of antiscalants. This study obtained a Sb-rich deposit by refluxing SbCl3 and Na2S·3H2O in 18 h. The product was found to be a mixture of Sb2O3 and Sb2S3. We examined the performance of antiscalants such as poly(ethylene glycol), poly(vinyl pyrrolidone), Gelatin, and poly(vinyl alcohol) of various molecular weights at 5 to 100 ppm. The formation of Sb2S3 is suppressed in the presence of the polymeric antiscalants. The dosage was found to be critical for the solubilization of Sb-rich deposits. Gelatin of 5 ppm showed the highest performance under the conditions employed in this study. While low dosages improve the concentration of [Sb3+], high dosages are required to increase the solubility of [S2-]. Moreover, the amount of deposit is reduced by 12.4% compared to the reference (in the absence of any polymeric molecules). Thus, comparatively, Gelatin shows the most promising performance among the molecules employed.

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Sizing and Thermal Stability of Prepared Tetraaminophthalocyaninatocopper(II) Derivatives-grafted Polymers

Baghdad Science Journal ◽

10.21123/bsj.13.2.221-234 ◽

2016 ◽

Vol 13 (2) ◽

pp. 221-234

Author(s):

Baghdad Science Journal

Keyword(s):

Thermal Stability ◽

Ethylene Glycol ◽

Group Analysis ◽

Condensation Polymerization ◽

Grafted Polymers ◽

Poly Ethylene Glycol ◽

Molecular Weights ◽

Poly Ethylene ◽

Thermal Stability Of ◽

End Group

Different polymers were prepared by condensation polymerization of sebacic anhydride and adipic anhydride with ethylene glycol and poly(ethylene glycol). Their number average molecular weights were determined by end group analysis. Then, they were grafted on the prepared phthalocyaninatocopper(II) compounds with the general formula (NH2)4PcCu(II) having amino groups of 3,3',3'',3'''- or 4,4',4'',4'''- positions. All prepared polymers, compounds, and phthalocyaninatocopper(II)-grafted polymers were characterized by FTIR. The sizing measurements were carried out in 3,3',3'',3'''- (NH2)4PcCu(II) and 4,4',4'',4'''- (NH2)4PcCu(II) compounds with and without grafting polymers. The results showed that the grafting process led to decreasing in particle size and increasing in surface area. The grafting process was reflected positively on the thermal degradation of 3,3',3'',3'''- (NH2)4PcCu(II) and 4,4',4'',4'''- (NH2)4PcCu(II) grafted polymers. They had higher thermal stability accompanied with higher char residue and T50% weight loss with 3,3',3'',3'''-(NH2)4PcCu(II) and their grafted polymers being the best.

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