Association of severity of diabetic retinopathy with corneal endothelial and thickness changes in patients with diabetes mellitus

Introduction: Normal bacterial flora may be altered by a variety of factors. Objective: To study the aerobic bacterial conjunctival flora in patients with diabetes mellitus and to find its clinical significance by comparing the results to the conjunctival flora of non-diabetic subjects. Materials and methods: A total of 75 diabetic patients were included as cases and 25 nondiabetics as controls to compare the results. Specimens for the study of conjunctival flora were taken by rubbing sterile cotton-tipped swabs to the inferior palbebral conjunctiva. The conjunctival culture report of the patients with diabetic mellitus was compared to that of nondiabetic subjects. Results: Positive conjunctival cultures were seen in a higher percentage of patients with diabetes (unilateral and bilateral positive conjunctival cultures 34.66 % and 58.66 % respectively) compared to that in non-diabetic controls (unilateral and bilateral positive conjunctival cultures 24 % and 16 % respectively). Diabetics showed a higher proportion of coagulase negative staphylococci (45.33 %), compared to the non-diabetic group (16 %). Among the diabetic patients, positive conjunctival cultures were detected more frequently in those with diabetic retinopathy compared to those without retinopathy. A higher proportions of bilateral positive conjunctival cultures were seen in cases with proliferative diabetic retinopathy (38.63 %) in comparison to patients with no retinopathy and different stages of non-proliferative diabetic retinopathy. Conclusion: The conjunctival floral pattern with increased bacteria in diabetics is a predominant cause of many diabetes-related ocular infections. The presence of diabetic retinopathy is an indicator for increased colonization of conjunctiva, and its severity correlates with the severity of diabetic retinopathy. Nepal J Ophthalmol 2013; 5(9):28-32 DOI: http://dx.doi.org/10.3126/nepjoph.v5i1.7818

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Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. ETDRS Investigators

JAMA ◽

10.1001/jama.268.10.1292 ◽

1992 ◽

Vol 268 (10) ◽

pp. 1292-1300 ◽

Cited By ~ 65

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Early Treatment ◽

Mortality And Morbidity ◽

Study Report ◽

Patients With Diabetes

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Assessment of Absorption of Glycated Nail Proteins in Patients with Diabetes Mellitus and Diabetic Retinopathy

Medicina ◽

10.3390/medicina56120658 ◽

2020 ◽

Vol 56 (12) ◽

pp. 658

Author(s):

Ieva Jurgeleviciene ◽

Daiva Stanislovaitiene ◽

Vacis Tatarunas ◽

Marius Jurgelevicius ◽

Dalia Zaliuniene

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Ftir Spectroscopy ◽

Region Of Interest ◽

Control Group ◽

Before And After ◽

Patients With Diabetes ◽

Long Term Observation

Background and objectives: Glycation occurs in a variety of human tissues and organs. Knowledge about the relationship between predictive biochemical factors such as absorption of glycated nail proteins and severity of type 2 diabetes mellitus (DM) and diabetic retinopathy (DR) remains limited. Materials and Methods: The study group consisted of patients with type 2 DM and DR (n = 32) and a control group (n = 28). Each patient underwent a comprehensive ophthalmic examination. The glycation process in nail clippings was evaluated in stages of in vitro glycation and deglycation stages. ATR–FTIR spectroscopy was used to calculate the infrared absorption in the region of interest. The absorption of solutions with nail clippings was evaluated by NanoDrop spectrophotometry. Absorption spectra differences before and after the exposure to fructosamine 3-kinase were compared between DM patients with DR and the control group. Results: The absorption of glycated nail protein greater than 83.00% increased the chance of developing DM and DR (OR = 15.909, 95% CI 3.914–64.660, p < 0.001). Absorption of glycated nail protein by ATR–FTIR spectroscopy in patients with DM and DR in vitro glycation was statistically significantly higher than in the control group; also absorption of solution with nails by NanoDrop spectroscopy was statistically significantly higher than in controls in vitro glycation and in vitro deglycation. After exposure to fructosamine 3-kinase, absorption of nail protein in DM + severe/proliferative DR group was statistically significantly lower in comparison with DM + mild/moderate group DR. Conclusions: Evaluation of glycated nail protein could be applied to evaluate the risk of having DM and for long-term observation of DM control.

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Role of early screening for diabetic retinopathy in patients with diabetes mellitus: An overview

Indian Journal of Community Medicine ◽

10.4103/0970-0218.91324 ◽

2011 ◽

Vol 36 (4) ◽

pp. 247 ◽

Cited By ~ 28

Author(s):

Praveen Vashist ◽

Noopur Gupta ◽

Sameeksha Singh ◽

Rohit Saxena

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Early Screening ◽

Patients With Diabetes

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Awareness about diabetes mellitus and diabetic retinopathy in patients with diabetes mellitus

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20173564 ◽

2017 ◽

Vol 5 (8) ◽

pp. 3570

Author(s):

Neeti R. Sheth ◽

Nabilah A. Sareshwala ◽

Sushil G. Chaudhary ◽

Hiren D. Matai

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Public Awareness ◽

Good Control ◽

Poor Control ◽

Medical College ◽

Patients With Diabetes ◽

Detailed Search ◽

Age Range ◽

Poor Practice

Background: Awareness about diabetes mellitus and diabetic retinopathy in patients with diabetes mellitus.Methods: 50 patients of diabetes mellitus attending Pandit Deendayal Upadhyay Medical College, Rajkot, Gujarat, India, were randomly selected during January 2017 to March 2017. 11-point questionnaire obtained on detailed search of literature on published reports were administered by interviewers well versed in English and Gujarati.Results: Total of 50 patients were randomly selected.42%- females and 58% - males. Mean age - 58.5 years. Age range 40 to 71 years. Patients with good sugar control -26% and poor control - 74%. 94% of the patients were taking treatment for DM and 6% were not on any treatment. 48 % of the patients were illiterate, 10% were graduate and 42% had education below 12th standard. 50% were aware about DM affecting the eye .38% had taken eye treatment and 62% had not. 26% were aware of DM affecting eye inspite of good control and 26 % aware of the need of check-up in poor control. 40% aware of the complications related to DM.Conclusions: Better literacy rates is contributory to public awareness, however trend for poor practice needs to be radically changed with aggressive public motivation emphasizing the necessity of screening and follow ups.

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Knowledge about Diabetic Retinopathy, Eye Check-up Practice and Associated Factors among Adult Patients with Diabetes Mellitus Attending at Debark Hospital, Northwest Ethiopia

10.21203/rs.2.16562/v5 ◽

2020 ◽

Author(s):

Abel Sinshaw Assem ◽

Mebratu Muusew Tegegne ◽

Destaye Shiferaw Alemu ◽

Asamere Tsegaw Woredekal ◽

Tsehay Kassa Tefera

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Northwest Ethiopia ◽

Good Knowledge ◽

Eye Disease ◽

Diabetic Patients ◽

Duration Of Diabetes ◽

Patients With Diabetes ◽

History Of ◽

Eye Examination

Abstract Background: Routine eye examination plays a vital role in detecting diabetic retinopathy in its earliest stage before the onset of blindness. Patients’ knowledge about the nature and the consequences of diabetic retinopathy and routine eye checkup helps for timely identification and early treatment. However, there is limited evidence on knowledge of patients with diabetes mellitus on diabetic retinopathy and their eye check-up practices in Ethiopia. The aim of this study was to assess knowledge about diabetic retinopathy, eye check-up practice and associated factors of diabetic retinopathy among adult diabetic patients at Debark hospital, Northwest Ethiopia. Methods: Institution based cross-sectional study was conducted at Debark hospital, Northwest Ethiopia, from April 20/2018- May 20/2018. A pretested interviewer administered structured questionnaire was used to collect data among 230 diabetic patients aged 18 years and above. Data were entered in to Epi Info version 7 and exported to SPSS version 20 for analysis. Bivariable and multivariable binary logistic regression analyses were done. Odds ratio with 95% confidence level was determined and variables with p–value of < 0.05 were considered as statistically significant. Result: Out of 238 sample 230 were participated, among this, 119 (51.7%) were males. The mean age of the respondents was 49 (SD ±17.6) years. One hundred nine (47.4%) participants had good knowledge and 91 (39.6%) had good eye check-up practice. Urban residence [AOR= 2.65;95% CI: 1.16-6.07)]), monthly income of 3501-8000 birr [AOR=4.54;(1.31-15.7)], type II diabetes mellitus [AOR=3.9;(1.6-9.6)], duration of diabetes (6-12 years[AOR=4.4;(1.4-13.5)]), history of eye disease [AOR=5.5;(2.3-13.0)] were associated with good knowledge. Similarly, longer duration of diabetes (13-25 years [AOR=3.77; (1.05-13.5)]) and history of eye disease [AOR=2.47; (1.09-5.62)] were associated with good eye check-up practice. Conclusion: The proportion of good knowledge about diabetic retinopathy among diabetic patients at Debark hospital was fair (47.4%) and good eye check-up practice (eye examination at least once in the past year) was low (39.6%). Longer duration of diabetes and history of eye disease were identified as positive factors for good knowledge and eye check-up practice. Knowledge and regular eye check-up practice needs to be enhanced through provision of appropriate health education.

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