Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity

S. W. Fanning; L. Hodges-Gallagher; D. C. Myles; R. Sun; C. E. Fowler; I. N. Plant; B. D. Green; C. L. Harmon; G. L. Greene; P. J. Kushner

doi:10.1038/s41467-018-04413-3

Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity

Nature Communications ◽

10.1038/s41467-018-04413-3 ◽

2018 ◽

Vol 9 (1) ◽

Cited By ~ 14

Author(s):

S. W. Fanning ◽

L. Hodges-Gallagher ◽

D. C. Myles ◽

R. Sun ◽

C. E. Fowler ◽

...

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Alpha ◽

Alpha Helix ◽

Receptor Alpha ◽

Antiestrogenic Activity ◽

Helix 12

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Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant

Cancer Biology & Therapy ◽

10.4161/cbt.9.5.10926 ◽

2010 ◽

Vol 9 (5) ◽

pp. 389-396 ◽

Cited By ~ 5

Author(s):

Xinghua Long ◽

Meiyun Fan ◽

Kenneth P. Nephew

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Alpha ◽

Receptor Alpha ◽

Antiestrogenic Activity

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Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2012.05.004 ◽

2012 ◽

Vol 132 (1-2) ◽

pp. 186-193 ◽

Cited By ~ 13

Author(s):

Bridgette M. Collins-Burow ◽

James W. Antoon ◽

Daniel E. Frigo ◽

Steven Elliott ◽

Christopher B. Weldon ◽

...

Keyword(s):

Estrogen Receptor ◽

Protein Kinase ◽

Estrogen Receptor Alpha ◽

Cell Type ◽

Terminal Protein ◽

Receptor Alpha ◽

Antiestrogenic Activity ◽

Cell Type Specific ◽

Specific Regulation ◽

Kinase Pathway

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Lack of Significant Estrogenic or Antiestrogenic Activity of Pyrethroid Insecticides in Three in Vitro Assays Based on Classic Estrogen Receptor alpha-Mediated Mechanisms

Toxicological Sciences ◽

10.1093/toxsci/57.1.54 ◽

2000 ◽

Vol 57 (1) ◽

pp. 54-60 ◽

Cited By ~ 56

Author(s):

K. Saito

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Alpha ◽

In Vitro Assays ◽

Pyrethroid Insecticides ◽

Receptor Alpha ◽

Antiestrogenic Activity

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Ligand Induced Solution Structure and Dynamics of the Helix‐12 region of Estrogen Receptor Alpha

The FASEB Journal ◽

10.1096/fasebj.21.5.a253-b ◽

2007 ◽

Vol 21 (5) ◽

Author(s):

Stefano Vincenzo Gulla ◽

David E Budil

Keyword(s):

Estrogen Receptor ◽

Solution Structure ◽

Estrogen Receptor Alpha ◽

Receptor Alpha ◽

Structure And Dynamics ◽

Helix 12

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Author response for "Estrogen receptor alpha, g‐protein coupled receptor 1, and aromatase: developmental, sex, and region‐specific differences across the rat caudate‐putamen, nucleus accumbens core and shell"

10.1002/cne.24978/v4/response1 ◽

2020 ◽

Author(s):

Amanda A. Krentzel ◽

Jaime A. Willett ◽

Ashlyn G. Johnson ◽

John Meitzen

Keyword(s):

Estrogen Receptor ◽

Nucleus Accumbens ◽

G Protein ◽

Estrogen Receptor Alpha ◽

Author Response ◽

G Protein Coupled Receptor ◽

Nucleus Accumbens Core ◽

Caudate Putamen ◽

Receptor Alpha ◽

G Protein Coupled

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Author response for "Estrogen receptor alpha, g‐protein coupled receptor 1, and aromatase: developmental, sex, and region‐specific differences across the rat caudate‐putamen, nucleus accumbens core and shell"

10.1002/cne.24978/v3/response1 ◽

2020 ◽

Author(s):

Amanda A. Krentzel ◽

Jaime A. Willett ◽

Ashlyn G. Johnson ◽

John Meitzen

Keyword(s):

Estrogen Receptor ◽

Nucleus Accumbens ◽

G Protein ◽

Estrogen Receptor Alpha ◽

Author Response ◽

G Protein Coupled Receptor ◽

Nucleus Accumbens Core ◽

Caudate Putamen ◽

Receptor Alpha ◽

G Protein Coupled

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Die Kaffee-vermittelte Induktion von UDP-Glukuronosyltransferasen wird durch den Estrogen-Receptor-alpha (ESR-1) geschlechtspezifisch reguliert

Zeitschrift für Gastroenterologie ◽

10.1055/s-0031-1285168 ◽

2011 ◽

Vol 49 (08) ◽

Author(s):

S Kalthoff ◽

A Winkler ◽

N Freiberg ◽

M Manns ◽

C Strassburg

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Alpha ◽

Receptor Alpha

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Mice lacking estrogen receptor [alpha] in hypothalamic POMC neurons display enhanced estrogenic response on cortical bone mass

Bone Abstracts ◽

10.1530/boneabs.5.ht2 ◽

2016 ◽

Author(s):

Helen Farman ◽

Sara Windahl ◽

Deborah Clegg ◽

Shang Kui Xie ◽

Lars Westberg ◽

...

Keyword(s):

Estrogen Receptor ◽

Bone Mass ◽

Cortical Bone ◽

Estrogen Receptor Alpha ◽

Receptor Alpha ◽

Cortical Bone Mass

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Faculty Opinions recommendation of Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1049341.501250 ◽

2006 ◽

Author(s):

Charles Irvin

Keyword(s):

Estrogen Receptor ◽

Airway Hyperresponsiveness ◽

Estrogen Receptor Alpha ◽

Receptor Alpha ◽

Deficient Mice

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Faculty Opinions recommendation of Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1071026.551964 ◽

2007 ◽

Author(s):

Andrea Gore

Keyword(s):

Metabolic Syndrome ◽

Estrogen Receptor ◽

Estrogen Receptor Alpha ◽

Ventromedial Nucleus ◽

Receptor Alpha

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