scholarly journals Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Hao Chen ◽  
Bo Hu ◽  
Xiao Lv ◽  
Shouan Zhu ◽  
Gehua Zhen ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Sensory Nerve ◽  
Bone Homeostasis ◽  
Nerve Regulation

scholarly journals PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib

Bone Research ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Peng Xue ◽  
Shenyu Wang ◽  
Xiao Lyu ◽  
Mei Wan ◽  
Xialin Li ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Low Dose ◽  
Sensory Nerve ◽  
Spinal Pain ◽  
Sensory Innervation ◽  
High Dose ◽  
Bone Homeostasis ◽  
Vertebral Endplate ◽  
Physiological Level ◽  
Pge2 Concentration

AbstractSkeletal interoception regulates bone homeostasis through the prostaglandin E2 (PGE2) concentration in bone. Vertebral endplates undergo ossification and become highly porous during intervertebral disc degeneration and aging. We found that the PGE2 concentration was elevated in porous endplates to generate spinal pain. Importantly, treatment with a high-dose cyclooxygenase 2 inhibitor (celecoxib, 80 mg·kg−1 per day) decreased the prostaglandin E2 concentration and attenuated spinal pain in mice with lumbar spine instability. However, this treatment impaired bone formation in porous endplates, and spinal pain recurred after discontinuing the treatment. Interestingly, low-dose celecoxib (20 mg·kg−1 per day, which is equivalent to one-quarter of the clinical maximum dosage) induced a latent inhibition of spinal pain at 3 weeks post-treatment, which persisted even after discontinuing treatment. Furthermore, when the prostaglandin E2 concentration was maintained at the physiological level with low-dose celecoxib, endplate porosity was reduced significantly, which was associated with decreased sensory nerve innervation and spinal pain. These findings suggest that low-dose celecoxib may help to maintain skeletal interoception and decrease vertebral endplate porosity, thereby reducing sensory innervation and spinal pain in mice.

scholarly journals Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Xiao Lv ◽  
Feng Gao ◽  
Tuo Peter Li ◽  
Peng Xue ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bone Formation ◽  
Free Fatty Acids ◽  
Leucine Zipper ◽  
Sensory Nerve ◽  
Bone Homeostasis ◽  
Y1 Receptor ◽  
Small Heterodimer Partner ◽  
The Central Nervous System ◽  
Leucine Zipper Protein

The central nervous system regulates activity of peripheral organs through interoception. In our previous study, we have demonstrated that PGE2/EP4 skeleton interception regulate bone homeostasis. Here, we show that ascending skeleton interoceptive signaling downregulates expression of hypothalamic neuropeptide Y (NPY) and induce lipolysis of adipose tissue for osteoblastic bone formation. Specifically, the ascending skeleton interoceptive signaling induces expression of small heterodimer partner-interacting leucine zipper protein (SMILE) in the hypothalamus. SMILE binds to pCREB as a transcriptional heterodimer on Npy promoters to inhibit NPY expression. Knockout of EP4 in sensory nerve increases expression of NPY causing bone catabolism and fat anabolism. Importantly, inhibition of NPY Y1 receptor (Y1R) accelerated oxidation of free fatty acids in osteoblasts and rescued bone loss in AvilCre:Ptger4fl/fl mice. Thus, downregulation of hypothalamic NPY expression lipolyzes free fatty acids for anabolic bone formation through a neuroendocrine descending interoceptive regulation.

Prostaglandin E2-Induced Sensory Nerve Activation Is Mediated By TRPA1 And TRPV1

2010 ◽  
Author(s):  
Sarah A. Maher ◽  
Megan S. Grace ◽  
Mark A. Birrell ◽  
Maria G. Belvisi
Keyword(s):  
Prostaglandin E2 ◽  
Sensory Nerve

Selectively enhanced prostaglandin E2 production by monocytes in atopic disease

1997 ◽  
Vol 56 (1-3) ◽  
pp. 48
Author(s):  
A Snijders
Keyword(s):  
Prostaglandin E2 ◽  
Atopic Disease

Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
S. Pecha ◽  
E. Mudersbach ◽  
F.M. Wagner ◽  
Y. Alassar ◽  
S. Hakmi ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Contractile Response ◽  
Cardiac Contractile

6-Mercaptopurin und 6-Thioguanin vermindern die Freisetzung von Prostaglandin E2 und 6-keto Prostaglandin F1α aus intestinalen Myofibroblasten in vitro

2015 ◽  
Vol 41 (08) ◽  
Author(s):  
S Schroll ◽  
K Felgenhauer ◽  
MP Manns ◽  
M Göke
Keyword(s):  
Prostaglandin E2

Inhibition of Prostaglandin E2 Production by a Combination of Flavonoids from Scutellaria baicalensis

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
T Shimizu ◽  
N Shibuya ◽  
T Fujii ◽  
M Tago ◽  
Y Narukawa ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Scutellaria Baicalensis
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