scholarly journals Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dexin Chen ◽  
Zhangyuanzhu Liu ◽  
Wenju Liu ◽  
Meiting Fu ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Metastasis ◽  
Radical Surgery ◽  
Tumour Size ◽  
Tumour Microenvironment ◽  
Serosal Invasion ◽  
Multiphoton Imaging ◽  
Node Metastasis ◽  
Differentiation Status ◽  
Tumour Differentiation

AbstractAccurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is crucial in clinic. The presence of collagen in the tumour microenvironment affects the metastasis of cancer cells. Herein, we propose a collagen signature, which is composed of multiple collagen features in the tumour microenvironment of the serosa derived from multiphoton imaging, to describe the extent of collagen alterations. We find that a high collagen signature is significantly associated with a high risk of peritoneal metastasis (P < 0.001). A competing-risk nomogram including the collagen signature, tumour size, tumour differentiation status and lymph node metastasis is constructed. The nomogram demonstrates satisfactory discrimination and calibration. Thus, the collagen signature in the tumour microenvironment of the gastric serosa is associated with peritoneal metastasis in GC with serosal invasion, and the nomogram can be conveniently used to individually predict the risk of peritoneal metastasis in GC with serosal invasion after radical surgery.

scholarly journals A nomogram based on glycomic biomarkers in serum and clinicopathological characteristics for evaluating the risk of peritoneal metastasis in gastric cancer

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Junjie Zhao ◽  
Ruihuan Qin ◽  
Hao Chen ◽  
Yupeng Yang ◽  
Wenjun Qin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Weight Loss ◽  
Peritoneal Metastasis ◽  
Lymphocyte Count ◽  
Clinical Decision Making ◽  
Tumour Size ◽  
Threshold Value ◽  
Clinical Decision ◽  
Signet Ring Cell ◽  
Clinicopathologic Characteristics

Abstract Background Peritoneal metastasis (PM) in gastric cancer (GC) remains an untreatable disease, and is difficult to diagnose preoperatively. Here, we aim to establish a novel prediction model. Methods The clinicopathologic characteristics of a cohort that included 86 non-metastatic GC patients and 43 PMGC patients from Zhongshan Hospital were retrospectively analysed to identify PM associated variables. Additionally, mass spectrometry and glycomic analysis were applied in the same cohort to find glycomic biomarkers in serum for the diagnosis of PM. A nomogram was established based on the associations between potential risk variables and PM. Results Overexpression of 4 N-glycans (H6N5L1E1: m/z 2620.93; H5N5F1E2: m/z 2650.98; H6N5E2, m/z 2666.96; H6N5L1E2, m/z 2940.08); weight loss ≥ 5 kg; tumour size ≥ 3 cm; signet ring cell or mucinous adenocarcinoma histology type; poor differentiation; diffuse or mixed Lauren classification; increased CA19-9, CA125, and CA724 levels; decreased lymphocyte count, haemoglobin, albumin, and pre-albumin levels were identified to be associated with PM. A nomogram that integrated with five independent risk factors (weight loss ≥ 5 kg, CA19-9 ≥ 37 U/mL, CA125 ≥ 35 U/mL, lymphocyte count < 2.0 * 10 ~ 9/L, and H5N5F1E2 expression ≥ 0.0017) achieved a good performance for diagnosis (AUC: 0.892, 95% CI 0.829–0.954). When 160 was set as the cut-off threshold value, the proposed nomogram represented a perfectly discriminating power for both sensitivity (0.97) and specificity (0.88). Conclusions The nomogram achieved an individualized assessment of the risk of PM in GC patients; thus, the nomogram could be used to assist clinical decision-making before surgery.

Role of intraoperative assessment of lymph node metastasis and serosal invasion in patients with gastric cancer

1994 ◽  
Vol 55 (4) ◽  
pp. 250-254 ◽  
Author(s):  
Daisuke Korenaga ◽  
Toshiro Okuyama ◽  
Hiroyuki Orita ◽  
Hideaki Anai ◽  
Hideo Baba ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Serosal Invasion ◽  
Node Metastasis ◽  
Intraoperative Assessment

Clinical impact of preoperative albumin to globulin ratio in gastric cancer patients with curative intent.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 13-13
Author(s):  
Yuji Toiyama ◽  
Masato Okigami ◽  
Hiromi Yasuda ◽  
Masaki Ohi ◽  
Koji Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Recurrence ◽  
Clinical Impact ◽  
Serosal Invasion ◽  
Curative Intent ◽  
Node Metastasis ◽  
Study Results ◽  
Albumin To Globulin Ratio

13 Background: Albumin to globulin ratio (AGR) has mainly been used as a clinical indicator for multiple myeloma or other immunoproliferative diseases. Recently, AGR has been reported to predict long term mortality in patients with nasopharyngeal carcinoma, colorectal cancer, lung cancer and breast cancer. However, clinical impact of preoperative AGR in gastric cancer (GC) has not yet been addressed. Therefore, we, for the first time, investigated the association between AGR and clinico-pathological findings including overall survival (OS) and disease free survival (DFS) in GC patients with curative intent. Methods: Clinicopathological findings including preoperative laboratory data (carcinoembryonic antigen [CEA], carbohydrate antigen [CA] 19-9 and AGR) from 384 curative GC patients were assessed as indicators of early recurrence and poor prognosis in this retrospective study. AGR was calculated as [AGR = albumin/ (total protein - albumin)]. The cut-off value of AGR was 1.4 in current study. Results: Several pathological categories related with tumor progression such as lymph node metastasis, tumor serosal invasion, large tumor size, venous invasion were significantly associated with lower AGR levels. In addition, significant negative correlation between AGR and age was found. Among preoperative serum markers, AGR was an independent predictor of early recurrence in curative GC patients after adjusted by age and sex. On the other hand, 2 pathological factors such as lymph node metastasis and serosal invasion were independent factors to identify early recurrence in curative GC patients among postoperative categories. Furthermore, sub analysis revealed that GC patients with AGR < 1.4 showed significant poorer DFS in both lymph node metastasis and serosal invasion group, respectively. Conclusions: Preoperative AGR may represent a simple, potentially useful predictive biomarker for selecting GC patients who might need neoadjuvant chemotherapy. Furthermore, AGR may select candidates who are better to introduce more intensive adjuvant chemotherapy after curative operation in stage II-III GC.

Survival analysis and clinical characteristics of forty-eight patients with alpha-fetoprotein-positive gastric cancer treated by integrated Chinese and western medicine.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15550-e15550
Author(s):  
Wenting He ◽  
Tong Zhang ◽  
Yanhong Xuan ◽  
Hongliang Zhang
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Chinese Medicine ◽  
Western Medicine ◽  
Clinical Characteristics ◽  
Alpha Fetoprotein ◽  
Serosal Invasion ◽  
Node Metastasis ◽  
Omental Metastasis

e15550 Background: Alpha-fetoprotein-producing gastric carcinoma (AFPGC) is a special type of gastric cancer, which has characteristics of strong invasiveness, prone to liver and lymphnode metastasis, easy misdiagnosis and worse prognosis. According to the literature, the survival of AFPGC was 4-14 months (m). There is no report about integrated Chinese and Western Medicine on the AFPGC patients. This study is to explore the effect of integrated Chinese and Western Medicine on the survival and clinical characteristics of patients with AFPGC. Methods: 398 consecutive patients with gastric cancer admitted to Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine from Jan 2012 to Jun 2018 were retrospectively collected. All patients were diagnosed by pathology. And on the basis treatment of conventional Western Medicine combined with Chinese Medicine for more than 3 m. Follow-up up to Dec 31th 2018. The median follow-up time was 11.1 m. According to the results of serum alpha-fetoprotein chemiluminescence assay, AFPGC was found in 48 out of 398 patients. The median overall survival (mOS) and clinical characteristics of AFPGC patients were analyzed. Results: Among 48 patients with AFPGC, 1 case (2.1%) in stage Ⅰ, 1 case (2.1%) in stage Ⅱ, 8 cases (16.7%) in stage Ⅲ, 36 cases (75.0%) in stage Ⅳ, and 2 cases with unknown stages; 35 cases (72.9%) received chemotherapy, 22 cases (45.8%) received local treatment, including palliative radiotherapy and hepatic artery chemoembolization, and 4 cases (8.3%) received targeted therapy. At the end of follow-up, 40 patients died, with the mOS of 16 m, 27.5 m in stage Ⅰ-Ⅲ and 14 m in stage Ⅳ, which was significantly longer than reported in the literature. Compared with non-AFPGC patients, tumor metastasis and serosal invasion of higher incidence ( 75.0% vs 38.9, x2= 22.3, p < 0.0001; 75.0% vs 38.9%, x2= 17.5, p = 0.0015 ). The incidence of liver and/or lymph node metastasis is higher (52.1% vs 17.4%, x2= 25.1, p < 0.0001; 33.3% vs 15.7%, x2= 7.7, p = 0.0054 ). The incidence of pleuroperitoneal and omental metastasis is higher (33.3% vs 11.7%, x2= 13.0, p = 0.0003 ). Conclusions: Integrated Chinese and Western Medicine can significantly prolong the survival of patients with AFPGC. AFPGC seem to be more prone to tumour metastasis, serosal invasion, liver metastasis, lymph node metastasis, pleuroperitoneal and omental metastasis. However, limited by the sample size, whether the above factors are independent prognostic factors for AFPGC is still not conclusive.

scholarly journals Real-time optical diagnosis of gastric cancer with serosal invasion using multiphoton imaging

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jun Yan ◽  
Yu Zheng ◽  
Xiaoling Zheng ◽  
Zhangyuanzhu Liu ◽  
Wenju Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Real Time ◽  
Optical Diagnosis ◽  
Serosal Invasion ◽  
Multiphoton Imaging

scholarly journals PINCH Expression and Its Clinicopathological Significance in Gastric Adenocarcinoma

2012 ◽  
Vol 33 (4) ◽  
pp. 171-178 ◽  
Author(s):  
Zhen-Long Zhu ◽  
Bao-Yong Yan ◽  
Yu Zhang ◽  
Yan-Hong Yang ◽  
Zheng-Min Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Adenocarcinoma ◽  
Tumour Size ◽  
Normal Gastric Mucosa ◽  
Invasion Depth ◽  
Node Metastasis ◽  
Positive Rate ◽  
Clinicopathological Significance ◽  
Gastric Cancer Patients ◽  
Gastric Mucous

Objective: Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in patients with colorectal cancer. However, there is no study of PINCH in gastric cancer, therefore, the aim of this project was to investigate PINCH expression and its clinicopathological significance in gastric adenocarcinoma.Patients and methods: PINCH expression was immunohistochemically examined in normal gastric mucous (n= 30) and gastric adenocarcinoma (n= 73), from gastric cancer patients.Results: PINCH expression in the associated-stroma of gastric cancers was heterogeneous, and its positive rate (75%) was higher than that of normal gastric mucosa (43%,X2= 9.711,p= 0.002). The stronger staining was observed at the invasive edge of tumour when compared to the inner area of tumour. The rate of positive PINCH (88%) in the cases with lymph node metastasis was higher than that (52%) in the cases without metastasis (X2= 11.151,p= 0.001). PINCH expression was not correlated with patients’ gender, age, tumour size, differentiation and invasion depth (p> 0.05).Comclusion: PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma.

scholarly journals Abstract 4030: Loss of E-cadherin expression is a critical step for peritoneal metastasis of gastric cancer with sub-serosal invasion

2018 ◽  
Author(s):  
Shingo Togano ◽  
Masakazu Yashiro ◽  
Kenji Kuroda ◽  
Tomohisa Okuno ◽  
Yuichiro Miki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Peritoneal Metastasis ◽  
Serosal Invasion ◽  
Critical Step ◽  
E Cadherin
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