scholarly journals The role of retrotransposable elements in ageing and age-associated diseases

Nature ◽  
2021 ◽  
Vol 596 (7870) ◽  
pp. 43-53
Author(s):  
Vera Gorbunova ◽  
Andrei Seluanov ◽  
Paolo Mita ◽  
Wilson McKerrow ◽  
David Fenyö ◽  
...  
Keyword(s):  
Retrotransposable Elements ◽  
Associated Diseases

COVID-19 and Comorbidities: is Inflammation the Underlying Condition in Children? A narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Giulia Pinna ◽  
Lavinia Sanfilippo ◽  
Pier Paolo Bassareo ◽  
Vassilios Fanos ◽  
Maria Antonietta Marcialis
Keyword(s):  
Risk Factor ◽  
Severe Form ◽  
Narrative Review ◽  
Underlying Condition ◽  
Pathogenic Mechanisms ◽  
Associated Diseases ◽  
Potential Link

: This paper examines the potential link between COVID-19 and the presence of comorbidities and assesses the role of inflammation in this correlation. In COVID-19 patients, the most frequently associated diseases share a pathogenic inflammatory basis and apparently act as a risk factor in the onset of a more severe form of the disease, particularly in adulthood. However, in children, the understanding of the underlying pathogenic mechanisms is often complicated by the milder symptoms presented. A series of theories have therefore been put forward with a view of providing a better understanding of the role played by inflammation in this dramatic setting. All evidence available to date on this topic is discussed in this review.

scholarly journals Role of long non‐coding RNAs in adipogenesis: State of the art and implications in obesity and obesity‐associated diseases

2021 ◽  
Author(s):  
Federica Rey ◽  
Valentina Urrata ◽  
Luisa Gilardini ◽  
Simona Bertoli ◽  
Valeria Calcaterra ◽  
...  
Keyword(s):  
State Of The Art ◽  
Associated Diseases ◽  
Non Coding Rnas

scholarly journals Aberrant mitochondrial RNA in the role of aging and aging associated diseases

2015 ◽  
Vol 85 (2) ◽  
pp. 178-182 ◽  
Author(s):  
Yucai Chen ◽  
W. Davis Parker ◽  
Hongyi Chen ◽  
Kunfang Yang
Keyword(s):  
Mitochondrial Rna ◽  
Associated Diseases

scholarly journals Insights into the role of endoplasmic reticulum stress in skin function and associated diseases

FEBS Journal ◽  
2019 ◽  
Vol 286 (2) ◽  
pp. 413-425 ◽  
Author(s):  
Kyungho Park ◽  
Sang Eun Lee ◽  
Kyong-Oh Shin ◽  
Yoshikazu Uchida
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Associated Diseases ◽  
Skin Function

scholarly journals Corrigendum: Role of Viral and Host microRNAs in Immune Regulation of Epstein-Barr Virus-Associated Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Hisashi Iizasa ◽  
Hyoji Kim ◽  
Andy Visi Kartika ◽  
Yuichi Kanehiro ◽  
Hironori Yoshiyama
Keyword(s):  
Immune Regulation ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Associated Diseases ◽  
Epstein Barr

scholarly journals 15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

PPAR Research ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Jingjing Li ◽  
Chuanyong Guo ◽  
Jianye Wu
Keyword(s):  
Peroxisome Proliferator ◽  
Defence Mechanism ◽  
Endogenous Ligand ◽  
Peroxisome Proliferator Activated Receptor ◽  
Associated Diseases ◽  
Ppar Γ ◽  
Structure Synthesis ◽  
Functional Mechanisms ◽  
Prostaglandin J2

15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR-γ signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects. Although many synthetic PPAR-γ receptor agonists have been developed, as an endogenous product of PPAR-γ receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism. In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-γ. It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases.

Sign in / Sign up

Export Citation Format

Share Document