scholarly journals Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

2018 ◽  
Vol 25 (1) ◽  
pp. 130-140 ◽  
Author(s):  
Matteo Menotti ◽  
Chiara Ambrogio ◽  
Taek-Chin Cheong ◽  
Chiara Pighi ◽  
Ines Mota ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Suppressor ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Wiskott Aldrich Syndrome ◽  
Syndrome Protein

scholarly journals Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

PLoS Genetics ◽  
2016 ◽  
Vol 12 (9) ◽  
pp. e1006334 ◽  
Author(s):  
Staci L. Haney ◽  
G. Michael Upchurch ◽  
Jana Opavska ◽  
David Klinkebiel ◽  
Ryan A. Hlady ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Suppressor ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma

scholarly journals Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor geneCADM1, and its interacting partnerDAL-1in nasal NK/T-cell lymphoma

2009 ◽  
Vol 124 (7) ◽  
pp. 1572-1578 ◽  
Author(s):  
Li Fu ◽  
Zifen Gao ◽  
Xiaohua Zhang ◽  
Ying Hung Tsang ◽  
Hwee Koon Goh ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Suppressor ◽  
Cell Lymphoma ◽  
Epigenetic Silencing ◽  
T Cell Lymphoma ◽  
Nk T Cell

scholarly journals MicroRNA-146a Downregulates NFκB Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma

2011 ◽  
Vol 17 (14) ◽  
pp. 4761-4771 ◽  
Author(s):  
Jin Ho Paik ◽  
Ji-Young Jang ◽  
Yoon Kyung Jeon ◽  
Wook Youn Kim ◽  
Tae Min Kim ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Suppressor ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Prognostic Implications ◽  
Nk T Cell

The Role of Mir-150 as a Tumor Suppressor In Malignant Lymphoma

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 465-465
Author(s):  
Atsushi Watanabe, ◽  
Hiroyuki Tagawa ◽  
Kazuaki Teshima ◽  
Yoshihiro Kameoka ◽  
Naoto Takahashi ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Suppressor ◽  
Cell Lines ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
Telomerase Activity ◽  
Akt Signaling ◽  
T Cell Lymphoma ◽  
Nk T Cell

Abstract Abstract 465 Disease specific genetic alteration or translocation have not been identified in NK/T cell lymphoma. We recently demonstrated that over expressions of miR-21 and/or miR-155 are frequently occurring in natural killer (NK) cell lymphoma/leukemia and deeply associated with their lymphomagenesis by deregulation of AKT signaling. In this study, we tried to identify tumor suppressor miRNA(s) in malignant lymphomas including B-cell, NK-cell and CD4+T-cell lymphoma, by using quantitative PCR and/or Northern blot analysis. We found that miR-150 in both cell lines and primary samples of NK and T-cell lymphoma showed significantly lower expression than those of normal natural killer cells and CD4+T cells. To examine the role for lymphomagenesis, we stably transduced miR-150 into lymphoma cell lines. Enforced expression of miR-150 in NK/T cell lymphoma cell lines showed increased levels of susceptibility of apoptosis, and showed senescence with reduced levels of telomerase activity and telomere DNA shortening. We further demonstrated that miR-150 directly down regulate AKT2, leading to reduced expression of phosphorylated AKTser473/474 with upregulation of tumor suppressors, Bim, p27 and p53. Since it has been proven that AKT kinase phosphorylate hTERT (human telomerase reverse transcript), downregulation of miR-150 in lymphomas lead to activate telomerase activity, resulting immortalization of the cancer cells. These results suggest that miR-150 play as a role of tumor suppressor in NK/T-cell lymphoma. Our recent and previous report demonstrate that downregulation of miR-150 and upregulation of miR-21/miR-155 collaborately contribute to NK/T-cell lymphomagenesis by deregulating AKT signaling. These findings will give a new insight into the pathogenesis of NK/T cell lymphoma and the miR-150 itself and/or AKT targeting therapy can be a useful against aggressive lymphoma. Disclosures: No relevant conflicts of interest to declare.

scholarly journals AMP-Activated Protein Kinase: Friend or Foe in Cancer?

2020 ◽  
Vol 4 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Diana Vara-Ciruelos ◽  
Madhumita Dandapani ◽  
D. Grahame Hardie
Keyword(s):  
T Cell ◽  
Protein Kinase ◽  
Tumor Suppressor ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Tumor Initiation ◽  
Energy Stress ◽  
Lung Cancer Model ◽  
Cell Growth And Proliferation ◽  
Amp Activated Protein Kinase

The AMP-activated protein kinase (AMPK) is activated by energy stress and restores homeostasis by switching on catabolism, while switching off cell growth and proliferation. Findings that AMPK acts downstream of the tumor suppressor LKB1 have suggested that AMPK might also suppress tumorigenesis. In mouse models of B and T cell lymphoma in which genetic loss of AMPK occurred before tumor initiation, tumorigenesis was accelerated, confirming that AMPK has tumor-suppressor functions. However, when loss of AMPK in a T cell lymphoma model occurred after tumor initiation, or simultaneously with tumor initiation in a lung cancer model, the disease was ameliorated. Thus, once tumorigenesis has occurred, AMPK switches from tumor suppression to tumor promotion. Analysis of alterations in AMPK genes in human cancers suggests similar dichotomies, with some genes being frequently amplified while others are mutated. Overall, while AMPK-activating drugs might be effective in preventing cancer, in some cases AMPK inhibitors might be required to treat it.

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