AI as a new paradigm for risk-based screening for breast cancer

2022 ◽  
Author(s):  
Nehmat Houssami ◽  
Karla Kerlikowske
Keyword(s):  
Breast Cancer ◽  
New Paradigm

scholarly journals A New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3141
Author(s):  
Aurora Laborda-Illanes ◽  
Lidia Sánchez-Alcoholado ◽  
Soukaina Boutriq ◽  
Isaac Plaza-Andrades ◽  
Jesús Peralta-Linero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gut Microbiota ◽  
Bacterial Population ◽  
Kynurenine Pathway ◽  
New Paradigm ◽  
Bacterial Composition ◽  
Glucuronidase Activity ◽  
The One ◽  
The Relationship ◽  
Melatonin Production

In this review we summarize a possible connection between gut microbiota, melatonin production, and breast cancer. An imbalance in gut bacterial population composition (dysbiosis), or changes in the production of melatonin (circadian disruption) alters estrogen levels. On the one hand, this may be due to the bacterial composition of estrobolome, since bacteria with β-glucuronidase activity favour estrogens in a deconjugated state, which may ultimately lead to pathologies, including breast cancer. On the other hand, it has been shown that these changes in intestinal microbiota stimulate the kynurenine pathway, moving tryptophan away from the melatonergic pathway, thereby reducing circulating melatonin levels. Due to the fact that melatonin has antiestrogenic properties, it affects active and inactive estrogen levels. These changes increase the risk of developing breast cancer. Additionally, melatonin stimulates the differentiation of preadipocytes into adipocytes, which have low estrogen levels due to the fact that adipocytes do not express aromatase. Consequently, melatonin also reduces the risk of breast cancer. However, more studies are needed to determine the relationship between microbiota, melatonin, and breast cancer, in addition to clinical trials to confirm the sensitizing effects of melatonin to chemotherapy and radiotherapy, and its ability to ameliorate or prevent the side effects of these therapies.

Concurrent chemoradiotherapy for locally advanced breast cancer—time for a new paradigm?

2014 ◽  
Vol 22 (1) ◽  
pp. 25 ◽  
Author(s):  
V. Mandilaras ◽  
N. Bouganim ◽  
J. Spayne ◽  
R. Dent ◽  
A. Arnaout ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
New Paradigm

Sodium/potasium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: a new paradigm for development of anti- breast cancer drugs?

2005 ◽  
Vol 96 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Jin-Qiang Chen ◽  
Ruben G. Contreras ◽  
Richard Wang ◽  
Sandra V. Fernandez ◽  
Liora Shoshani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cardiac Glycosides ◽  
Cancer Drugs ◽  
New Paradigm ◽  
Breast Cancer Drugs

Endocrine disruptors and the tumor microenvironment: A new paradigm in breast cancer biology

2017 ◽  
Vol 457 ◽  
pp. 13-19 ◽  
Author(s):  
Hope Burks ◽  
Nicholas Pashos ◽  
Elizabeth Martin ◽  
John Mclachlan ◽  
Bruce Bunnell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Endocrine Disruptors ◽  
Cancer Biology ◽  
New Paradigm

Using Pictures to Evoke Spiritual feelings in Breast Cancer Patients: Development of a New Paradigm for Neuroimaging Studies

2010 ◽  
Vol 50 (2) ◽  
pp. 437-446 ◽  
Author(s):  
L. L. Symonds ◽  
L. Yang ◽  
M. M. Mande ◽  
L. A. Mande ◽  
A. J. Blow ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
New Paradigm

scholarly journals Complex interaction of adipokines in breast cancer and anti-tumour immunity; a new paradigm for cancer treatment

2021 ◽  
Vol 5 (2) ◽  
pp. 01-16
Author(s):  
Peng H Tan ◽  
Mingrui Xie ◽  
Eleftherios Sfakianakis
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Immune Cells ◽  
Cell Transformation ◽  
Direct Consequence ◽  
New Paradigm ◽  
Fat Cell ◽  
Tumour Immunity ◽  
Developed World

Obesity and its related complications have been the pressing disease pandemic affecting the developed world. It is well-established that the direct consequence of obesity in the cardiovascular system resulting in many diseases. However, its implications in carcinogenesis, cancer treatment and one’s anti-tumour immunity are gradually unfolding. To understand how fat cells can affect these, one needs to explore how the fat cell affects epithelial and immune cells. To this end, we explore the way how the adipocytes, via its production of adipokines, influence these cells, resulting in early epithelial cell transformation into cancer cells and influencing anti-tumour immunity once the cancer is established. In order to simplify our discussion, we focus this review on breast cancer. We propose that to have an effective therapy for cancer treatment, we need to intervene at the adipokine interaction with epithelial cells, cancer cells, and immune cells. In this review we also decipher the potential therapeutic targets in controlling carcinogenesis and disease progression.

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