scholarly journals Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Szabina Horváth ◽  
Rita Komlódi ◽  
Anikó Perkecz ◽  
Erika Pintér ◽  
Rolland Gyulai ◽  
...  
Keyword(s):  
Methodological Refinement

Developing the Methodology for an Applied, Interdisciplinary Research Project: Documenting the Journey Toward Philosophical Clarity

2015 ◽  
Vol 11 (4) ◽  
pp. 450-468 ◽  
Author(s):  
Loene M. Howes
Keyword(s):  
Mixed Methods ◽  
Interdisciplinary Research ◽  
Mixed Methods Research ◽  
Scientific Evidence ◽  
Research Project ◽  
Ongoing Research ◽  
Methodological Choices ◽  
Interdisciplinary Research Project ◽  
Logic Of Inquiry ◽  
Methodological Refinement

Methodologists have urged researchers who use mixed methods to justify their methodological choices and provide greater clarity about the philosophical underpinnings and implications of their approaches. This article outlines the reasoning process undertaken in an endeavor to develop philosophical clarity for an applied, interdisciplinary, mixed methods research project about the communication of scientific evidence in the legal system. I used Greene’s domains of methodology for social inquiry as a framework for addressing reflexive questions about assumptions. Flowing from the domains of values and philosophies, the logic of inquiry was developed before the implications for the integration of findings and reporting of research were outlined. Early engagement in reflexive questioning provided a foundation for methodological refinement throughout the ongoing research journey.

Multilingual acquisition property by property: A view from a wider perspective

2020 ◽  
pp. 026765832093516
Author(s):  
Magdalena Wrembel
Keyword(s):  
Second Language ◽  
Language Acquisition ◽  
Research Data ◽  
Property A ◽  
Third Language ◽  
Third Language Acquisition ◽  
Language Research ◽  
Interesting Contribution ◽  
Methodological Refinement

This commentary discusses the recent keynote article in Second Language Research by Westergaard (2019), which is an interesting contribution to the field of language acquisition and multilingualism, especially because it attempts to provide a wider perspective by embracing first, second and third language acquisition. I address major claims put forward by Westergaard, to support them with my own research data from the domain of phonology as well as to raise some questions as to potential limitations of the approach, and to point to avenues for future theoretical and methodological refinement.

scholarly journals Histochemistry as a versatile research toolkit in biological research, not only an applied discipline in pathology

2018 ◽  
Vol 62 (4) ◽  
Author(s):  
Carlo Pellicciari
Keyword(s):  
Scientific Field ◽  
Live Cells ◽  
Biological Research ◽  
Cellular Mechanisms ◽  
Diverse Range ◽  
Dynamic Events ◽  
Research Fields ◽  
Tissue Biology ◽  
Disease Specific ◽  
Methodological Refinement

The impressive progress of histochemistry over the last 50 years has led to setting up specific and sensitive techniques to describe dynamic events, through the detection of specific molecules in the very place where they exist in live cells. The scientific field where histochemistry has most largely been applied is histopathology, with the aim to identify disease-specific molecular markers or to elucidate the etiopathological mechanisms. Numerous authors did however apply histochemistry to a variety of other research fields; their interests range from the microanatomy of animal and plant organisms to the cellular mechanisms of life. This is especially apparent browsing the contents of the histochemical journals where the articles on subjects other than pathology are the majority; these journals still keep a pivotal role in the field of cell and tissue biology, while being a forum for a diverse range of biologists whose scientific interests expand  the research horizon of histochemistry to ever novel subjects. Thus, histochemistry can always receive inspiring stimuli toward a continuous methodological refinement.

scholarly journals The Social Regulation of Uneven Development: ‘Regulatory Deficit’, England's South East, and the Collapse of Thatcherism

1995 ◽  
Vol 27 (1) ◽  
pp. 15-40 ◽  
Author(s):  
J Peck ◽  
A Tickell
Keyword(s):  
Uneven Development ◽  
Social Regulation ◽  
The South ◽  
Regulation Theory ◽  
Régulation Theory ◽  
The Social ◽  
Regional Restructuring ◽  
Methodological Refinement

The evolving methodology of regulation theory is explored, with particular reference to the problematic of uneven development. With a concentration on the subnational scale, the notion of localised modes of regulation is critically examined. With a view to operationalising some of these regulationist concepts, an analysis of the geographical contradictions of Thatcherism is presented. Thatcherism, it is suggested, should be interpreted as a failed or failing regulatory experiment, the contradictions of which are manifest in a variety of ways, including in the geographical sphere—in the collapse of the economy of the South East of England (Thatcherism's ‘heartland’ region) and in Britain's continuing crisis of uneven development. There is scope, it is argued, further to spatialise regulation theory through methodological refinement, and through analyses of regional restructuring and crisis.

scholarly journals A multilevel perspective of transition to a circular economy with particular reference to a community renewable energy niche

2020 ◽  
Vol 19 (2) ◽  
pp. 195-220
Author(s):  
Jack Finn ◽  
Jack Barrie ◽  
Elsa João ◽  
Girma Zawdie
Keyword(s):  
Renewable Energy ◽  
Circular Economy ◽  
Delphi Study ◽  
Full System ◽  
Radical Innovations ◽  
System Transition ◽  
Multilevel Perspective ◽  
Scottish Government ◽  
Methodological Refinement

This article is an attempt to look into the processes involved in achieving full system transition to a circular economy (CE) through the development of niche activities. Based on a case study relating to a community renewable energy (CRE) niche, the article argues that for transition to take hold and make progress, the socio-technical regimes underpinning the system of a linear economy would need to be disrupted through the agency of niches that bring forth radical innovations across a spectrum of activities. This argument is explored through a case study from the energy sector in Scotland. A Delphi study is conducted to assess the success of the Scottish Government in progressing CRE as a niche aimed at disrupting the incumbent fossil-based energy regime. The study finds that despite the commitment of the Scottish Government to empower, nurture and shield CRE as a niche, there is no clear evidence as yet to show whether these actions have achieved their desired effect of enabling the CRE niche to play a disruptive role. The article also underscores the need for methodological refinement to enhance the robustness of the data used in the evaluation of policy efforts in niche development as a strategy for transition to CE.

A Methodological Refinement in the Study of "ESP," and Negative Findings

Science ◽  
1954 ◽  
Vol 120 (3108) ◽  
pp. 148-149 ◽  
Author(s):  
K. Smith ◽  
H. J. Canon
Keyword(s):  
Negative Findings ◽  
Methodological Refinement

scholarly journals AllCoPol: inferring allele co-ancestry in polyploids

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Ulrich Lautenschlager ◽  
Florian Wagner ◽  
Christoph Oberprieler
Keyword(s):  
Sequence Data ◽  
Heuristic Method ◽  
Species Trees ◽  
Phylogenetic Reconstructions ◽  
Disomic Inheritance ◽  
Simplifying Assumptions ◽  
Topological Errors ◽  
Programming Knowledge ◽  
Python Package ◽  
Methodological Refinement

Abstract Background Inferring phylogenetic relationships of polyploid species and their diploid ancestors (leading to reticulate phylogenies in the case of an allopolyploid origin) based on multi-locus sequence data is complicated by the unknown assignment of alleles found in polyploids to diploid subgenomes. A parsimony-based approach to this problem has been proposed by Oberprieler et al. (Methods Ecol Evol 8:835–849, 2017), however, its implementation is of limited practical value. In addition to previously identified shortcomings, it has been found that in some cases, the obtained results barely satisfy the applied criterion. To be of better use to other researchers, a reimplementation with methodological refinement appears to be indispensable. Results We present the AllCoPol package, which provides a heuristic method for assigning alleles from polyploids to diploid subgenomes based on the Minimizing Deep Coalescences (MDC) criterion in multi-locus sequence datasets. An additional consensus approach further allows to assess the confidence of phylogenetic reconstructions. Simulations of tetra- and hexaploids show that under simplifying assumptions such as completely disomic inheritance, the topological errors of reconstructed phylogenies are similar to those of MDC species trees based on the true allele partition. Conclusions AllCoPol is a Python package for phylogenetic reconstructions of polyploids offering enhanced functionality as well as improved usability. The included methods are supplied as command line tools without the need for prior programming knowledge.

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