Molecular complexity of the major urinary protein system of the Norway rat, Rattus norvegicus

The genomes of rats and mice both contain a cluster of multiple genes that encode small (18–20 kDa) eight-stranded β-barrel lipocalins that are expressed in multiple secretory tissues, some of which enter urine via hepatic biosynthesis. These proteins have been given different names, but are mostly generically referred to as MUPs (major urinary proteins). The mouse MUP cluster is increasingly well understood, and, in particular, a number of roles for MUPs in chemical communication between conspecifics have been established. By contrast, the literature on the rat orthologues is much less well developed and is fragmented. In the present review, we summarize current knowledge on the MUPs from the Norway (or brown) rat, Rattus norvegicus.

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Norway rat (Rattus norvegicus) ectoparasites in livestock production systems from central Argentina: Influencing factors on parasitism

Acta Tropica ◽

10.1016/j.actatropica.2019.105299 ◽

2020 ◽

Vol 203 ◽

pp. 105299

Author(s):

R. Alonso ◽

M. Ruiz ◽

R. Lovera ◽

D.P. Montes De Oca ◽

R. Cavia ◽

...

Keyword(s):

Influencing Factors ◽

Rattus Norvegicus ◽

Production Systems ◽

Livestock Production ◽

Norway Rat ◽

Central Argentina

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Kinetics of bromadiolone, anticoagulant rodenticide, in the norway rat (Rattus norvegicus)

Pharmacological Research Communications ◽

10.1016/0031-6989(87)90011-7 ◽

1987 ◽

Vol 19 (11) ◽

pp. 767-775 ◽

Cited By ~ 17

Author(s):

Nahas Kamil

Keyword(s):

Rattus Norvegicus ◽

Anticoagulant Rodenticide ◽

Norway Rat ◽

Kinetics Of

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Field trials of flocoumafen against warfarin-resistant infestations of the Norway rat (Rattus norvegicus Berk)

Journal of Hygiene ◽

10.1017/s0022172400066250 ◽

1986 ◽

Vol 96 (3) ◽

pp. 467-473 ◽

Cited By ~ 15

Author(s):

A. P. Buckle

Keyword(s):

Rattus Norvegicus ◽

Field Trials ◽

Anticoagulant Rodenticide ◽

Complete Control ◽

Norway Rat ◽

Norway Rats ◽

Farm Buildings

SUMMARYThe anticoagulant rodenticide flocoumafen was tested against warfarin-resistant Norway rats (Rattus norvegicus Berk.) infesting farm buildings. Complete control was obtained in 10–21 days (mean 14·2 days) in six treatments in which baits poisoned with 0·005% flocoumafen were maintained, in surplus, until rats ceased to feed from them. A further six treatments, in which the application of poisoned bait was restricted to periodic placements of 50 g, were also completely successful in 15–30 days (mean 21·0 days). Less poisoned bait was used in the restricted flocoumafen treatments than in the unrestricted treatments but the time taken to control the rat infestations was significantly longer.

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Major Urinary Protein Complex of Normal Mice: Origin

Science ◽

10.1126/science.149.3687.981 ◽

1965 ◽

Vol 149 (3687) ◽

pp. 981-982 ◽

Cited By ~ 102

Author(s):

J. S. Finlayson ◽

R. Asofsky ◽

M. Potter ◽

C. C. Runner

Keyword(s):

Protein Complex ◽

Urinary Protein ◽

Major Urinary Protein

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The morphological sequence of XY pairing in the Norway rat Rattus norvegicus

Chromosoma ◽

10.1007/bf00331256 ◽

1984 ◽

Vol 89 (5) ◽

pp. 381-386 ◽

Cited By ~ 22

Author(s):

A. M. Joseph ◽

Ann C. Chandley

Keyword(s):

Rattus Norvegicus ◽

Norway Rat

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Inheritance of Scottish-type resistance to warfarin in the Norway rat

Genetics Research ◽

10.1017/s001667230001692x ◽

1976 ◽

Vol 28 (3) ◽

pp. 231-239 ◽

Cited By ~ 15

Author(s):

J. H. Greaves ◽

P. B. Ayres

Keyword(s):

Resistance Gene ◽

Rattus Norvegicus ◽

Major Gene ◽

Inheritance Of Resistance ◽

Response To Selection ◽

Norway Rat ◽

Group I ◽

Wild Rat ◽

In The Wild ◽

Warfarin Resistance

SUMMARYThe inheritance of resistance to the rodenticide, warfarin, in the Norway rat, Rattus norvegicus, derived from a wild rat population in Scotland was studied in the backcross, intercross and testcross. The resistance was found to be due to a major gene with about the same map position in Linkage Group I as the warfarin-resistance gene, Rw2, which occurs in the wild rat population in Wales. In heterozygotes, the Scottish resistance gene, unlike the Welsh gene, is incompletely penetrant in expression, though the penetrance was found to increase markedly in response to selection. Differences between the Scottish and Welsh types of resistance suggest that the two resistance genes are allelic.

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