scholarly journals Jointly modelling longitudinally measured urinary human chorionic gonadotrophin and early pregnancy outcomes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
N. B. Ashra ◽  
L. Marriott ◽  
S. Johnson ◽  
K. R. Abrams ◽  
M. J. Crowther
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Outcomes ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin

Changes in peripheral progestagen levels in early pregnant gilts following injection of human chorionic gonadotrophin

1987 ◽  
Vol 115 (1) ◽  
pp. 161-167 ◽  
Author(s):  
B. A. Stone ◽  
P. A. Heap ◽  
R. F. Seamark
Keyword(s):  
Early Pregnancy ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Embryo Survival ◽  
Oestrone Sulphate

ABSTRACT The capacity of human chorionic gonadotrophin (hCG) to raise plasma progestagen levels during the first 8 days of gestation in gilts was examined. The effective half-times of hCG in gilts treated with 500 and 5000 i.u. hCG were 29·1 and 26·3 h respectively (P >0·05). Neither 500 nor 5000 i.u. hCG caused rises in peripheral concentrations of progesterone or pregnenolone sulphate, and plasma pregnenolone concentrations declined (P <0·05) following hCG treatment. Apart from diminished total corpus luteal weights in gilts treated with 500 i.u. hCG (P <0·05) and lower peripheral progesterone levels in gilts treated with 5000 i.u. hCG (P <0·05), ovarian and plasma steroid characteristics of hCG-treated animals between 23 and 25 days of gestation were similar to control values. Furthermore, treatment with hCG did not affect embryo survival during the first 4 weeks of pregnancy, and plasma oestrone/oestrone sulphate levels provided no evidence for differences between control and treated animals in trophoblastic out-growth. These results challenge the rationale for the treatment of early pregnant sows with hCG in order to reduce the levels of embryonic wastage in early pregnancy. J. Endocr. (1987) 115, 161–167

Evaluation of the sub-human primate tube test for pregnancy in primates

1976 ◽  
Vol 10 (2) ◽  
pp. 87-91 ◽  
Author(s):  
B. M. Hobson
Keyword(s):  
Luteinizing Hormone ◽  
Early Pregnancy ◽  
False Positive ◽  
Haemagglutination Inhibition ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Tube Test ◽  
Positive Results ◽  
Orang Utan ◽  
Human Primate

A haemagglutination inhibition test, developed specifically for primates, diagnoses early pregnancy in the chimpanzee, gorilla, orang-utan and baboon. The test was sensitive and reacted positively when the concentration of gonadotrophin in urine was equivalent to 0·03 i.u. human chorionic gonadotrophin per ml. This degree of sensitivity and the certitude that it cross-reacts with primate luteinizing hormone probably accounts for most of the false positive results.

scholarly journals Human chorionic gonadotrophin concentrations in early pregnancy after in-vitro fertilization

1999 ◽  
Vol 14 (6) ◽  
pp. 1642-1646 ◽  
Author(s):  
Sverre Bjercke ◽  
Tom Tanbo ◽  
Per Olav Dale ◽  
Lars Mørkrid ◽  
Thomas Åbyholm
Keyword(s):  
In Vitro Fertilization ◽  
Early Pregnancy ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Vitro Fertilization

scholarly journals Role of human chorionic gonadotrophin to prevent repeated early pregnancy loss

2016 ◽  
Vol 48 (1-2) ◽  
pp. 7-10
Author(s):  
Eti Saha ◽  
Fouzia Begum ◽  
Zannatul Ferdous Jesmin
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Loss ◽  
First Trimester ◽  
Additional Treatment ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Early Pregnancy Loss ◽  
Significant Difference ◽  
Improve Pregnancy Outcome ◽  
History Of

Early pregnancy loss is a frustrating experience for both the patient and the physician. Approximately 5% of couples trying to conceive have 2 consecutive miscarriages and approximately 1% couples have 3 or more consecutive losses. Objective of this study is to determine whether therapy with dydrogesterone or Human chorionic Gonadotrophin hormone (HCG) in history of repeated pregnancy loss during the first trimester of pregnancy will improve pregnancy outcome. This is a prospective open comparative study.Women having early pregnancy presenting to a private clinic with history of early pregnancy loss, having no medical disorder were included in this study. Eligible subjects were randomised to receive either dydrogesterone 20mg daily or injection Human Chorionic Gonadotrophins (HCG) 5000 iu intramuscularly at 72 hours interval up to fourteen weeks of pregnancy or no additional treatment. Follow up of those patients were done with transabdominal ultrasonography. Hundred women were recruited. There was no statistically significant difference between the three groups with regard to pretreatment status. The continuing pregnancy success rate was higher in women treated with dydrogesterone (79.17%) and highest with Injection Human Chorionic, Gonadotrophin (86.36%) compared with women received no treatment (70%), (p=0.358). Hormonal support with either dydrogesterone or Human Chorionic Gonadotrophin may increase the chances of a successful pregnancy in women with a history of spontaneous abortion.Bang Med J (Khulna) 2015; 48 : 7-10

Total amounts of circulating human chorionic gonadotrophin α and β subunits can be assessed throughout human pregnancy using immunoradiometric assays calibrated with the unaltered and thermally dissociated heterodimer

1994 ◽  
Vol 140 (3) ◽  
pp. 513-520 ◽  
Author(s):  
A-M Nagy ◽  
D Glinoer ◽  
G Picelli ◽  
J Delogne-Desnoeck ◽  
B Fleury ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Thermal Dissociation ◽  
Heat Exposure ◽  
Free Fraction ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Β Subunit ◽  
Human Pregnancy ◽  
Molar Basis ◽  
Α And Β Subunits

Abstract The aim of the present study was to determine the variations in the balance between total (free plus combined) circulating α and β subunits of human chorionic gonadotrophin (hCG) throughout human pregnancy. The equivalence between the International Units (IU) of hCG (IRP 75/537) and those assigned to the α (IRP 75/569) and β (IRP 75/551) free subunits was experimentally determined by using intact and thermally dissociated hCG. Heat exposure (2 min at 100 °C) of hCG preparations resulted in a complete dissociation of hCG into free, soluble and intact α and β subunits. The hCG and α and β subunit contents of unaltered and heated hCG preparations were assessed by specific immunoradiometric assays. The amount of immunoreactive subunits dissociated by heat from hCG could then be evaluated on a molar basis. Circulating hCG and its free α and β subunits were immunoassayed in 836 blood samples collected from healthy pregnant women at different gestational ages. After conversion of hCG and its subunits into a common IU system, the gestational profiles of the total amounts (free plus combined) of α- and βhCG subunits increased together and peaked at 9–10 weeks of gestation. Thereafter, total α and β subunits decreased and subsequently remained stable until term. The decline in total αhCG subunit was less marked than that of total βhCG subunit. The α- to βhCG ratio was equimolar until 10 weeks of gestation when it increased almost fourfold until term (P<0·0001). Finally, the free fraction of the total circulating αhCG subunit represented 5–7% in early pregnancy but reached 60–70% in the last trimester (P<0·0001). In contrast, the free fraction of the total βhCG subunit decreased slightly from 4–5% of total β subunit in early pregnancy to 2–3% at term (P<0·0001). The present study suggests that thermal dissociation of hCG is a useful method with which to calibrate immunoassays on a molar basis in order to assess circulating levels of the heterodimer and its subunits. Journal of Endocrinology (1994) 140, 513–520

scholarly journals Rapid one step urine test for human chorionic gonadotrophin in evaluating suspected complications of early pregnancy.

BMJ ◽  
1991 ◽  
Vol 302 (6788) ◽  
pp. 1308-1311 ◽  
Author(s):  
J C Kingdom ◽  
T Kelly ◽  
A B MacLean ◽  
E J McAllister
Keyword(s):  
Early Pregnancy ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Urine Test ◽  
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