scholarly journals Ascorbate maintains a low plasma oxygen level

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Louise Injarabian ◽  
Marc Scherlinger ◽  
Anne Devin ◽  
Stéphane Ransac ◽  
Jens Lykkesfeldt ◽  
...  
Keyword(s):  
1992 ◽  
Vol 86 (1) ◽  
pp. 168-172 ◽  
Author(s):  
Faustino Menegus ◽  
Liliana Cattaruzza ◽  
Leonardo Scaglioni ◽  
Enzio Ragg

Author(s):  
Junchao Qian ◽  
Xiang Yu ◽  
Bingbing Li ◽  
Zhenle Fei ◽  
Xiang Huang ◽  
...  

Background:: It was known that the response of tumor cells to radiation is closely related to tissue oxygen level and fractionated radiotherapy allows reoxygenation of hypoxic tumor cells. Non-invasive mapping of tissue oxygen level may hold great importance in clinic. Objective: The aim of this study is to evaluate the role of oxygen-enhanced MR imaging in the detection of tissue oxygen levels between fractionated radiotherapy. Methods: A cohort of 10 patients with brain metastasis was recruited. Quantitative oxygen enhanced MR imaging was performed prior to, 30 minutes and 22 hours after first fractionated radiotherapy. Results: The ΔR1 (the difference of longitudinal relaxivity between 100% oxygen breathing and air breathing) increased in the ipsilateral tumor site and normal tissue by 242% and 152%, respectively, 30 minutes after first fractionated radiation compared to pre-radiation levels. Significant recovery of ΔR1 in the contralateral normal tissue (p < 0.05) was observed 22 hours compared to 30 minutes after radiation levels. Conclusion: R1-based oxygen-enhanced MR imaging may provide a sensitive endogenous marker for oxygen changes in the brain tissue between fractionated radiotherapy.


Nanoscale ◽  
2021 ◽  
Author(s):  
Zhenyu Duan ◽  
Qiang Luo ◽  
Lei Gu ◽  
Xiaoling Li ◽  
Hongyan Zhu ◽  
...  

A hypoxic environment in tumors hampers the therapeutic efficacy of radiotherapy. Moreover, radiotherapy, a localized treatment technique, can barely control tumor metastases. Herein, poly(lactic co-glycolic acid) was used to encapsulate...


Author(s):  
Yun Wei ◽  
Jianguo Wu ◽  
Jianping Huang ◽  
Xiaoyue Liu ◽  
Dongliang Han ◽  
...  
Keyword(s):  

2021 ◽  
Vol 696 ◽  
pp. 178838
Author(s):  
Xing Liu ◽  
Houzhang Tan ◽  
Xuebin Wang ◽  
Zhao Wang ◽  
Jiaye Zhang ◽  
...  

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