scholarly journals Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kazuhisa Chihara ◽  
Naoki Hattori ◽  
Norihiro Ichikawa ◽  
Takeshi Matsuda ◽  
Takanori Saito
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Fat ◽  
Fat Mass ◽  
Inflammatory Markers ◽  
Joint Damage ◽  
Bone Destruction ◽  
Body Fat Mass ◽  
Serum Leptin

Abstract Leptin and adiponectin are produced mainly in adipocytes and classified as adipocytokines because of their possible involvement in inflammation and immunity. The aim of this study was to elucidate the relationships of these adipocytokines with the disease activities of RA. We examined leptin and adiponectin concentrations and inflammatory markers such as metalloproteinase-3 (MMP-3) in 136 patients with rheumatoid arthritis (RA) (26 males and 110 females, 69.6 ± 9.3 years) and 78 controls (36 males and 42 females, 66.7 ± 15.0 years). Serum leptin and adiponectin concentrations correlated positively (r = 0.565, P < 0.001) and negatively (r = –0.331, P < 0.001) to the amount of body fat, respectively. Serum leptin and adiponectin concentrations normalized by body fat mass were significantly higher in RA than those in controls [leptin, 1.24 (median) ng/mL/kg fat in RA vs. 0.76 ng/mL/kg fat in controls; adiponectin, 0.74 μg/mL/kg fat in RA vs. 0.44 μg/mL/kg fat in controls]. Normalized adiponectin concentrations correlated positively not only to the degree of bone destruction in Steinbrocker classification but also to serum MMP-3 concentrations. Normalized leptin concentrations did not correlate to the degree of bone destruction. We conclude that adiponectin but not leptin may be involved in joint damage in RA.

Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass

2002 ◽  
Vol 39 (3) ◽  
pp. 105-110 ◽  
Author(s):  
S. Fischer ◽  
M. Hanefeld ◽  
S. M. Haffner ◽  
C. Fusch ◽  
U. Schwanebeck ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Serum Leptin ◽  
Insulin Resistant

The Relation Between Serum Leptin Levels and Body Fat Mass in Patients with Active Lung Tuberculosis

2003 ◽  
Vol 29 (3) ◽  
pp. 257-264 ◽  
Author(s):  
İlhami Yüksel ◽  
Mehmet Şencan ◽  
Hatice Sebila Dökmetaş ◽  
İlyas Dökmetaş ◽  
Hilmi Ataseven ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Serum Leptin ◽  
Lung Tuberculosis

Diet and Diet Combined with Chronic Aerobic Exercise Decreases Body Fat Mass and Alters Plasma and Adipose Tissue Inflammatory Markers in Obese Women

Inflammation ◽  
2013 ◽  
Vol 36 (6) ◽  
pp. 1239-1247 ◽  
Author(s):  
Nadia Lakhdar ◽  
Myriam Denguezli ◽  
Monia Zaouali ◽  
Abdelkrim Zbidi ◽  
Zouhair Tabka ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Aerobic Exercise ◽  
Body Fat ◽  
Fat Mass ◽  
Inflammatory Markers ◽  
Body Fat Mass ◽  
Obese Women

scholarly journals Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women

2002 ◽  
pp. 173-180 ◽  
Author(s):  
M Matsubara ◽  
S Maruoka ◽  
S Katayose
Keyword(s):  
Gene Product ◽  
Body Fat ◽  
Fat Mass ◽  
Normal Weight ◽  
Body Fat Mass ◽  
Obese Women ◽  
Serum Leptin ◽  
Plasma Adiponectin ◽  
Significant Independent Variable ◽  
Independent Variable

BACKGROUND: Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of the adipose most-abundant gene transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects. OBJECTIVE: To characterize the relationship between adiponectin and leptin, the ob gene product, in normal-weight and obese women. DESIGN AND METHODS: In this cross-sectional study, we measured fasting plasma adiponectin by ELISA, leptin concentrations by RIA, and related parameters such as blood pressure, body mass index (BMI), body fat mass, lipids, fasting blood glucose and insulin in 353 non-diabetic adult women with a wide range of BMI values. RESULTS: Plasma adiponectin concentrations in women with the highest tertile of BMI (at least 25.0 kg/m(2)) were decreased compared with those in the middle (22.0-25.0 kg/m(2)) or lowest (<or=22.0 kg/m(2)) tertile of BMI (means+/-s.e.m.: 6.7+/-0.3 microg/ml compared with 8.6+/-0.4 microg/ml and 9.2+/-0.3 microg/ml; both P<0.0001). Serum leptin concentrations in women with the highest tertile of BMI were increased compared with those in women in the middle or lowest tertile of BMI (13.2+/-0.4 ng/ml compared with 8.1+/-0.2 ng/ml and 5.2+/-0.2 ng/ml; both P<0.0001). These relationships were similar after adjustment for BMI or body fat mass. Adiponectin was negatively correlated with serum leptin concentration, fasting immunoreactive insulin, calculated insulin resistance (homeostasis model assessment), BMI and body fat mass. These negative relationships became stronger after adjustment for BMI or body fat mass. In stepwise regression analyses, leptin was the significant independent variable for adiponectin, and adiponectin was also the significant independent variable for leptin before and after adjustment for BMI or body fat mass. CONCLUSIONS: In this study, we found an inverse correlation between adiponectin and leptin in vivo.

Serum leptin and adiponectin levels in children with type 1 diabetes mellitus – Relation to body fat mass and disease course

2016 ◽  
Vol 61 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Katarzyna Anna Majewska ◽  
Dominik Majewski ◽  
Bogda Skowrońska ◽  
Witold Stankiewicz ◽  
Piotr Fichna
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Disease Course ◽  
Serum Leptin

Body Fat Mass and Serum Leptin Levels Influence Epoetin Sensitivity in Patients With ESRD

2005 ◽  
Vol 46 (4) ◽  
pp. 628-634 ◽  
Author(s):  
Jonas Axelsson ◽  
Abdul Rashid Qureshi ◽  
Olof Heimbürger ◽  
Bengt Lindholm ◽  
Peter Stenvinkel ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Serum Leptin

Seasonal variations of body mass, thermogenesis and digestive tract morphology in Apodemus chevrieri in Hengduan mountain region

2012 ◽  
Vol 62 (4) ◽  
pp. 463-478 ◽  
Author(s):  
Zhu Wan-long ◽  
Yang Sheng-chang ◽  
Zhang Lin ◽  
Wang Zheng-kun
Keyword(s):  
Body Weight ◽  
Digestive Tract ◽  
Energy Intake ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Seasonal Variations ◽  
Body Fat Mass ◽  
Serum Leptin ◽  
Hengduan Mountain

Seasonal changes in an animal’s morphology, physiology, and behavior are considered to be an adaptive strategy for survival and reproductive success. We hypothesize that Apodemus chevrieri will change their thermogenesis seasonally and serum leptin will change with body mass or body fat mass. Seasonal variations in body mass (BM), basal metabolic rate (BMR), nonshivering thermogenesis (NST), digestive tract morphology, serum leptin and uncoupling protein 1 (UCP1) were measured in wild-trapped A. chevrieri in Hengduan mountain region. The results showed that the body weight of A. chevrieri was lowest in winter and highest in summer. Decreased BM in the winter was accompanied by increased energy intake and enhanced NST and UCP1 as well as by decreased body fat mass, adjusted digestive tract morphology and reduced levels of circulating leptin. Further, serum leptin were positively correlated with body weight and body fat mass, and negatively correlated with energy intake and UCP1 contents. These data suggest that wild A. chevrieri do not depend on a decrease in BM, but instead increase their thermogenic capacity to cope with cold stress. Leptin may be involved in the seasonal regulation in energy balance and thermogenesis in field A. chevrieri.

Sign in / Sign up

Export Citation Format

Share Document