Body Fat Mass and Serum Leptin Levels Influence Epoetin Sensitivity in Patients With ESRD

BACKGROUND: Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of the adipose most-abundant gene transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects. OBJECTIVE: To characterize the relationship between adiponectin and leptin, the ob gene product, in normal-weight and obese women. DESIGN AND METHODS: In this cross-sectional study, we measured fasting plasma adiponectin by ELISA, leptin concentrations by RIA, and related parameters such as blood pressure, body mass index (BMI), body fat mass, lipids, fasting blood glucose and insulin in 353 non-diabetic adult women with a wide range of BMI values. RESULTS: Plasma adiponectin concentrations in women with the highest tertile of BMI (at least 25.0 kg/m(2)) were decreased compared with those in the middle (22.0-25.0 kg/m(2)) or lowest (<or=22.0 kg/m(2)) tertile of BMI (means+/-s.e.m.: 6.7+/-0.3 microg/ml compared with 8.6+/-0.4 microg/ml and 9.2+/-0.3 microg/ml; both P<0.0001). Serum leptin concentrations in women with the highest tertile of BMI were increased compared with those in women in the middle or lowest tertile of BMI (13.2+/-0.4 ng/ml compared with 8.1+/-0.2 ng/ml and 5.2+/-0.2 ng/ml; both P<0.0001). These relationships were similar after adjustment for BMI or body fat mass. Adiponectin was negatively correlated with serum leptin concentration, fasting immunoreactive insulin, calculated insulin resistance (homeostasis model assessment), BMI and body fat mass. These negative relationships became stronger after adjustment for BMI or body fat mass. In stepwise regression analyses, leptin was the significant independent variable for adiponectin, and adiponectin was also the significant independent variable for leptin before and after adjustment for BMI or body fat mass. CONCLUSIONS: In this study, we found an inverse correlation between adiponectin and leptin in vivo.

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Serum leptin and adiponectin levels in children with type 1 diabetes mellitus – Relation to body fat mass and disease course

Advances in Medical Sciences ◽

10.1016/j.advms.2015.10.002 ◽

2016 ◽

Vol 61 (1) ◽

pp. 117-122 ◽

Cited By ~ 4

Author(s):

Katarzyna Anna Majewska ◽

Dominik Majewski ◽

Bogda Skowrońska ◽

Witold Stankiewicz ◽

Piotr Fichna

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Body Fat ◽

Fat Mass ◽

Body Fat Mass ◽

Disease Course ◽

Serum Leptin

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Seasonal variations of body mass, thermogenesis and digestive tract morphology in Apodemus chevrieri in Hengduan mountain region

Animal Biology ◽

10.1163/157075612x650140 ◽

2012 ◽

Vol 62 (4) ◽

pp. 463-478 ◽

Cited By ~ 14

Author(s):

Zhu Wan-long ◽

Yang Sheng-chang ◽

Zhang Lin ◽

Wang Zheng-kun

Keyword(s):

Body Weight ◽

Digestive Tract ◽

Energy Intake ◽

Body Mass ◽

Body Fat ◽

Fat Mass ◽

Seasonal Variations ◽

Body Fat Mass ◽

Serum Leptin ◽

Hengduan Mountain

Seasonal changes in an animal’s morphology, physiology, and behavior are considered to be an adaptive strategy for survival and reproductive success. We hypothesize that Apodemus chevrieri will change their thermogenesis seasonally and serum leptin will change with body mass or body fat mass. Seasonal variations in body mass (BM), basal metabolic rate (BMR), nonshivering thermogenesis (NST), digestive tract morphology, serum leptin and uncoupling protein 1 (UCP1) were measured in wild-trapped A. chevrieri in Hengduan mountain region. The results showed that the body weight of A. chevrieri was lowest in winter and highest in summer. Decreased BM in the winter was accompanied by increased energy intake and enhanced NST and UCP1 as well as by decreased body fat mass, adjusted digestive tract morphology and reduced levels of circulating leptin. Further, serum leptin were positively correlated with body weight and body fat mass, and negatively correlated with energy intake and UCP1 contents. These data suggest that wild A. chevrieri do not depend on a decrease in BM, but instead increase their thermogenic capacity to cope with cold stress. Leptin may be involved in the seasonal regulation in energy balance and thermogenesis in field A. chevrieri.

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Effects of fasting and re-feeding on energy metabolism and thermogenesis in the tree shrew (Tupaia belangeri)

Animal Biology ◽

10.1163/15707563-00002427 ◽

2014 ◽

Vol 64 (1) ◽

pp. 31-47 ◽

Cited By ~ 6

Author(s):

Wen-rong Gao ◽

Wan-long Zhu ◽

Di Zhang ◽

Shu-ran Sun ◽

Zheng-kun Wang

Keyword(s):

Adipose Tissue ◽

Energy Metabolism ◽

Food Intake ◽

Body Mass ◽

Body Fat ◽

Fat Mass ◽

Tree Shrew ◽

Control Level ◽

Body Fat Mass ◽

Serum Leptin

To investigate the effect of fasting and re-feeding on energy metabolism and thermogenesis in the tree shrew (Tupaia belangeri), the changes in body mass and body fat mass, resting metabolic rate (RMR), non-shivering thermogenesis (NST), body composition, mitochondrial cytochrome c oxidase (COX) activity in liver and brown adipose tissue (BAT), uncoupling protein-1 (UCP1) content of BAT, serum leptin level and post-fasting food intake were monitored and measured. The results showed that fasting induced a significant reduction in body mass and body fat mass. Body mass was restored to the control level in re-feeding tree shrew except for the body fat. RMR and NST decreased significantly in response to fasting, and returned to the control level after re-feeding. Fasting induced significant reduction in total, but not specific, COX activity (nmol O2/min/total tissue) in liver and BAT, and UCP1 content in BAT, which was reversed after re-feeding 48 h. Fasting of 12 h induced a rapid reduction in serum leptin content. There were no post-fasting compensatory increases in food intake. Interestingly, the tree shrew did not recover adipose tissue mass, nor serum leptin levels, upon re-feeding. These results suggest that T. belangeri can adjust the status of its physiology integratively to cope with the lack of food by means of decreasing body mass, adaptive thermogenesis and serum leptin levels, and serum leptin level acted as a starvation signal to mediate predominantly the reduction in body mass and energy expenditure.

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Relationship between serum leptin immunoreactivity and body fat mass as estimated by use of a novel gas-phase Fourier transform infrared spectroscopy deuterium dilution method in cats

American Journal of Veterinary Research ◽

10.2460/ajvr.2000.61.796 ◽

2000 ◽

Vol 61 (7) ◽

pp. 796-801 ◽

Cited By ~ 70

Author(s):

Robert C. Backus ◽

Peter J. Havel ◽

Ronald L. Gingerich ◽

Quinton R. Rogers

Keyword(s):

Fourier Transform ◽

Infrared Spectroscopy ◽

Gas Phase ◽

Fourier Transform Infrared Spectroscopy ◽

Body Fat ◽

Fat Mass ◽

Dilution Method ◽

Body Fat Mass ◽

Serum Leptin ◽

Deuterium Dilution

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Re-evaluation of serum leptin and adiponectin concentrations normalized by body fat mass in patients with rheumatoid arthritis

Scientific Reports ◽

10.1038/s41598-020-73068-2 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Kazuhisa Chihara ◽

Naoki Hattori ◽

Norihiro Ichikawa ◽

Takeshi Matsuda ◽

Takanori Saito

Keyword(s):

Rheumatoid Arthritis ◽

Body Fat ◽

Fat Mass ◽

Inflammatory Markers ◽

Joint Damage ◽

Bone Destruction ◽

Body Fat Mass ◽

Serum Leptin

Abstract Leptin and adiponectin are produced mainly in adipocytes and classified as adipocytokines because of their possible involvement in inflammation and immunity. The aim of this study was to elucidate the relationships of these adipocytokines with the disease activities of RA. We examined leptin and adiponectin concentrations and inflammatory markers such as metalloproteinase-3 (MMP-3) in 136 patients with rheumatoid arthritis (RA) (26 males and 110 females, 69.6 ± 9.3 years) and 78 controls (36 males and 42 females, 66.7 ± 15.0 years). Serum leptin and adiponectin concentrations correlated positively (r = 0.565, P < 0.001) and negatively (r = –0.331, P < 0.001) to the amount of body fat, respectively. Serum leptin and adiponectin concentrations normalized by body fat mass were significantly higher in RA than those in controls [leptin, 1.24 (median) ng/mL/kg fat in RA vs. 0.76 ng/mL/kg fat in controls; adiponectin, 0.74 μg/mL/kg fat in RA vs. 0.44 μg/mL/kg fat in controls]. Normalized adiponectin concentrations correlated positively not only to the degree of bone destruction in Steinbrocker classification but also to serum MMP-3 concentrations. Normalized leptin concentrations did not correlate to the degree of bone destruction. We conclude that adiponectin but not leptin may be involved in joint damage in RA.

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