scholarly journals Effectiveness of transfer learning for enhancing tumor classification with a convolutional neural network on frozen sections

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Young-Gon Kim ◽  
Sungchul Kim ◽  
Cristina Eunbee Cho ◽  
In Hye Song ◽  
Hee Jin Lee ◽  
...  
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Transfer Learning ◽  
Frozen Section ◽  
Medical Center ◽  
External Validation ◽  
Model Performance ◽  
Classification Model ◽  
Training Dataset

AbstractFast and accurate confirmation of metastasis on the frozen tissue section of intraoperative sentinel lymph node biopsy is an essential tool for critical surgical decisions. However, accurate diagnosis by pathologists is difficult within the time limitations. Training a robust and accurate deep learning model is also difficult owing to the limited number of frozen datasets with high quality labels. To overcome these issues, we validated the effectiveness of transfer learning from CAMELYON16 to improve performance of the convolutional neural network (CNN)-based classification model on our frozen dataset (N = 297) from Asan Medical Center (AMC). Among the 297 whole slide images (WSIs), 157 and 40 WSIs were used to train deep learning models with different dataset ratios at 2, 4, 8, 20, 40, and 100%. The remaining, i.e., 100 WSIs, were used to validate model performance in terms of patch- and slide-level classification. An additional 228 WSIs from Seoul National University Bundang Hospital (SNUBH) were used as an external validation. Three initial weights, i.e., scratch-based (random initialization), ImageNet-based, and CAMELYON16-based models were used to validate their effectiveness in external validation. In the patch-level classification results on the AMC dataset, CAMELYON16-based models trained with a small dataset (up to 40%, i.e., 62 WSIs) showed a significantly higher area under the curve (AUC) of 0.929 than those of the scratch- and ImageNet-based models at 0.897 and 0.919, respectively, while CAMELYON16-based and ImageNet-based models trained with 100% of the training dataset showed comparable AUCs at 0.944 and 0.943, respectively. For the external validation, CAMELYON16-based models showed higher AUCs than those of the scratch- and ImageNet-based models. Model performance for slide feasibility of the transfer learning to enhance model performance was validated in the case of frozen section datasets with limited numbers.

scholarly journals Automatic Handgun Detection with Deep Learning in Video Surveillance Images

2021 ◽  
Vol 11 (13) ◽  
pp. 6085
Author(s):  
Jesus Salido ◽  
Vanesa Lomas ◽  
Jesus Ruiz-Santaquiteria ◽  
Oscar Deniz
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Video Surveillance ◽  
Automatic Detection ◽  
Public Spaces ◽  
Detection Methods ◽  
Training Dataset ◽  
Average Precision ◽  
Terrorist Acts

There is a great need to implement preventive mechanisms against shootings and terrorist acts in public spaces with a large influx of people. While surveillance cameras have become common, the need for monitoring 24/7 and real-time response requires automatic detection methods. This paper presents a study based on three convolutional neural network (CNN) models applied to the automatic detection of handguns in video surveillance images. It aims to investigate the reduction of false positives by including pose information associated with the way the handguns are held in the images belonging to the training dataset. The results highlighted the best average precision (96.36%) and recall (97.23%) obtained by RetinaNet fine-tuned with the unfrozen ResNet-50 backbone and the best precision (96.23%) and F1 score values (93.36%) obtained by YOLOv3 when it was trained on the dataset including pose information. This last architecture was the only one that showed a consistent improvement—around 2%—when pose information was expressly considered during training.

scholarly journals Automatic differentiation of thyroid scintigram by deep convolutional neural network: a dual center study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Pei Yang ◽  
Yong Pi ◽  
Tao He ◽  
Jiangming Sun ◽  
Jianan Wei ◽  
...  
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Convolutional Neural Network ◽  
Predictive Value ◽  
Automatic Differentiation ◽  
External Validation ◽  
Deep Convolutional Neural Network ◽  
Image Feature ◽  
Training Dataset ◽  
Internal Validation

Abstract Background 99mTc-pertechnetate thyroid scintigraphy is a valid complementary avenue for evaluating thyroid disease in the clinic, the image feature of thyroid scintigram is relatively simple but the interpretation still has a moderate consistency among physicians. Thus, we aimed to develop an artificial intelligence (AI) system to automatically classify the four patterns of thyroid scintigram. Methods We collected 3087 thyroid scintigrams from center 1 to construct the training dataset (n = 2468) and internal validating dataset (n = 619), and another 302 cases from center 2 as external validating datasets. Four pre-trained neural networks that included ResNet50, DenseNet169, InceptionV3, and InceptionResNetV2 were implemented to construct AI models. The models were trained separately with transfer learning. We evaluated each model’s performance with metrics as following: accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), recall, precision, and F1-score. Results The overall accuracy of four pre-trained neural networks in classifying four common uptake patterns of thyroid scintigrams all exceeded 90%, and the InceptionV3 stands out from others. It reached the highest performance with an overall accuracy of 92.73% for internal validation and 87.75% for external validation, respectively. As for each category of thyroid scintigrams, the area under the receiver operator characteristic curve (AUC) was 0.986 for ‘diffusely increased,’ 0.997 for ‘diffusely decreased,’ 0.998 for ‘focal increased,’ and 0.945 for ‘heterogeneous uptake’ in internal validation, respectively. Accordingly, the corresponding performances also obtained an ideal result of 0.939, 1.000, 0.974, and 0.915 in external validation, respectively. Conclusions Deep convolutional neural network-based AI model represented considerable performance in the classification of thyroid scintigrams, which may help physicians improve the interpretation of thyroid scintigrams more consistently and efficiently.

Using Convolutional Neural Networks for the Detection of Spinal Transverse Processes

2019 ◽  
Author(s):  
Victoria Wu
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Transverse Process ◽  
Classification Model ◽  
Ultrasound Images ◽  
Ultrasound Scan ◽  
X Ray ◽  
Scoliosis Screening

Introduction: Scoliosis, an excessive curvature of the spine, affects approximately 1 in 1,000 individuals. As a result, there have formerly been implementations of mandatory scoliosis screening procedures. Screening programs are no longer widely used as the harms often outweigh the benefits; it causes many adolescents to undergo frequent diagnosis X-ray procedure This makes spinal ultrasounds an ideal substitute for scoliosis screening in patients, as it does not expose them to those levels of radiation. Spinal curvatures can be accurately computed from the location of spinal transverse processes, by measuring the vertebral angle from a reference line [1]. However, ultrasound images are less clear than x-ray images, making it difficult to identify the spinal processes. To overcome this, we employ deep learning using a convolutional neural network, which is a powerful tool for computer vision and image classification [2]. Method: A total of 2,752 ultrasound images were recorded from a spine phantom to train a convolutional neural network. Subsequently, we took another recording of 747 images to be used for testing. All the ultrasound images from the scans were then segmented manually, using the 3D Slicer (www.slicer.org) software. Next, the dataset was fed through a convolutional neural network. The network used was a modified version of GoogLeNet (Inception v1), with 2 linearly stacked inception models. This network was chosen because it provided a balance between accurate performance, and time efficient computations. Results: Deep learning classification using the Inception model achieved an accuracy of 84% for the phantom scan.  Conclusion: The classification model performs with considerable accuracy. Better accuracy needs to be achieved, possibly with more available data and improvements in the classification model.  Acknowledgements: G. Fichtinger is supported as a Canada Research Chair in Computer-Integrated Surgery. This work was funded, in part, by NIH/NIBIB and NIH/NIGMS (via grant 1R01EB021396-01A1 - Slicer+PLUS: Point-of-Care Ultrasound) and by CANARIE’s Research Software Program.    Figure 1: Ultrasound scan containing a transverse process (left), and ultrasound scan containing no transverse process (right).                                Figure 2: Accuracy of classification for training (red) and validation (blue). References:           Ungi T, King F, Kempston M, Keri Z, Lasso A, Mousavi P, Rudan J, Borschneck DP, Fichtinger G. Spinal Curvature Measurement by Tracked Ultrasound Snapshots. Ultrasound in Medicine and Biology, 40(2):447-54, Feb 2014.           Krizhevsky A, Sutskeyer I, Hinton GE. (2012). ImageNet Classification with Deep Convolutional Neural Networks. Advances in Neural Information Processing Systems 25:1097-1105. 

scholarly journals A Deep Learning-Based Approach for the Detection of Early Signs of Gingivitis in Orthodontic Patients Using Faster Region-Based Convolutional Neural Networks

2020 ◽  
Vol 17 (22) ◽  
pp. 8447
Author(s):  
Dima M. Alalharith ◽  
Hajar M. Alharthi ◽  
Wejdan M. Alghamdi ◽  
Yasmine M. Alsenbel ◽  
Nida Aslam ◽  
...  
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Periodontal Disease ◽  
Convolutional Neural Network ◽  
Region Of Interest ◽  
Training Dataset ◽  
Detection Accuracy ◽  
Detection Model ◽  
Art Object ◽  
Orthodontic Patients

Computer-based technologies play a central role in the dentistry field, as they present many methods for diagnosing and detecting various diseases, such as periodontitis. The current study aimed to develop and evaluate the state-of-the-art object detection and recognition techniques and deep learning algorithms for the automatic detection of periodontal disease in orthodontic patients using intraoral images. In this study, a total of 134 intraoral images were divided into a training dataset (n = 107 [80%]) and a test dataset (n = 27 [20%]). Two Faster Region-based Convolutional Neural Network (R-CNN) models using ResNet-50 Convolutional Neural Network (CNN) were developed. The first model detects the teeth to locate the region of interest (ROI), while the second model detects gingival inflammation. The detection accuracy, precision, recall, and mean average precision (mAP) were calculated to verify the significance of the proposed model. The teeth detection model achieved an accuracy, precision, recall, and mAP of 100 %, 100%, 51.85%, and 100%, respectively. The inflammation detection model achieved an accuracy, precision, recall, and mAP of 77.12%, 88.02%, 41.75%, and 68.19%, respectively. This study proved the viability of deep learning models for the detection and diagnosis of gingivitis in intraoral images. Hence, this highlights its potential usability in the field of dentistry and aiding in reducing the severity of periodontal disease globally through preemptive non-invasive diagnosis.

scholarly journals Convolutional neural network for image classification based on transfer learning technique

2021 ◽  
Author(s):  
Ghassan Mohammed Halawani
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Image Classification ◽  
Transfer Learning ◽  
Learning Networks ◽  
The Neural Network ◽  
Learning Technique ◽  
Common Architecture

The main purpose of this project is to modify a convolutional neural network for image classification, based on a deep-learning framework. A transfer learning technique is used by the MATLAB interface to Alex-Net to train and modify the parameters in the last two fully connected layers of Alex-Net with a new dataset to perform classifications of thousands of images. First, the general common architecture of most neural networks and their benefits are presented. The mathematical models and the role of each part in the neural network are explained in detail. Second, different neural networks are studied in terms of architecture, application, and the working method to highlight the strengths and weaknesses of each of neural network. The final part conducts a detailed study on one of the most powerful deep-learning networks in image classification – i.e. the convolutional neural network – and how it can be modified to suit different classification tasks by using transfer learning technique in MATLAB.

scholarly journals Side Scan Sonar Shipwreck Image Recognition Algorithm based on Transfer Learning and Deep Learning

2021 ◽  
Vol 290 ◽  
pp. 02020
Author(s):  
Boyu Zhang ◽  
Xiao Wang ◽  
Shudong Li ◽  
Jinghua Yang
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Transfer Learning ◽  
Image Recognition ◽  
Correlated Data ◽  
Small Sample ◽  
Side Scan Sonar ◽  
Transfer Training ◽  
Small Sample Sizes

Current underwater shipwreck side scan sonar samples are few and difficult to label. With small sample sizes, their image recognition accuracy with a convolutional neural network model is low. In this study, we proposed an image recognition method for shipwreck side scan sonar that combines transfer learning with deep learning. In the non-transfer learning, shipwreck sonar sample data were used to train the network, and the results were saved as the control group. The weakly correlated data were applied to train the network, then the network parameters were transferred to the new network, and then the shipwreck sonar data was used for training. These steps were repeated using strongly correlated data. Experiments were carried out on Lenet-5, AlexNet, GoogLeNet, ResNet and VGG networks. Without transfer learning, the highest accuracy was obtained on the ResNet network (86.27%). Using weakly correlated data for transfer training, the highest accuracy was on the VGG network (92.16%). Using strongly correlated data for transfer training, the highest accuracy was also on the VGG network (98.04%). In all network architectures, transfer learning improved the correct recognition rate of convolutional neural network models. Experiments show that transfer learning combined with deep learning improves the accuracy and generalization of the convolutional neural network in the case of small sample sizes.

scholarly journals Improving generalization of deep learning models for diagnostic pathology by increasing variability in training data: experiments on osteosarcoma subtypes

2020 ◽  
Author(s):  
Haiming Tang ◽  
Nanfei Sun ◽  
Steven Shen
Keyword(s):  
Deep Learning ◽  
Model Performance ◽  
High Variability ◽  
Training Data ◽  
Classification Model ◽  
Training Dataset ◽  
Learning Models ◽  
Diagnostic Pathology ◽  
Model Generalization ◽  
Histopathological Images

Artificial intelligence (AI) has an emerging progress in diagnostic pathology. A large number of studies of applying deep learning models to histopathological images have been published in recent years. While many studies claim high accuracies, they may fall into the pitfalls of overfitting and lack of generalization due to the high variability of the histopathological images. We use the example of Osteosarcoma to illustrate the pitfalls and how the addition of model input variability can help improve model performance. We use the publicly available osteosarcoma dataset to retrain a previously published classification model for osteosarcoma. We partition the same set of images into the training and testing datasets differently than the original study: the test dataset consists of images from one patient while the training dataset consists images of all other patients. The performance of the model on the test set using the new partition schema declines dramatically, indicating a lack of model generalization and overfitting.We also show the influence of training data variability on model performance by collecting a minimal dataset of 10 osteosarcoma subtypes as well as benign tissues and benign bone tumors of differentiation. We show the additions of more and more subtypes into the training data step by step under the same model schema yield a series of coherent models with increasing performances. In conclusion, we bring forward data preprocessing and collection tactics for histopathological images of high variability to avoid the pitfalls of overfitting and build deep learning models of higher generalization abilities.

scholarly journals Efficient Pneumonia Detection in Chest Xray Images Using Deep Transfer Learning

Diagnostics ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 417 ◽  
Author(s):  
Mohammad Farukh Hashmi ◽  
Satyarth Katiyar ◽  
Avinash G Keskar ◽  
Neeraj Dhanraj Bokde ◽  
Zong Woo Geem
Keyword(s):  
Deep Learning ◽  
Transfer Learning ◽  
Data Augmentation ◽  
Medical Center ◽  
Training Dataset ◽  
Test Accuracy ◽  
X Rays ◽  
Learning Models ◽  
Novel Approach ◽  
Unseen Data

Pneumonia causes the death of around 700,000 children every year and affects 7% of the global population. Chest X-rays are primarily used for the diagnosis of this disease. However, even for a trained radiologist, it is a challenging task to examine chest X-rays. There is a need to improve the diagnosis accuracy. In this work, an efficient model for the detection of pneumonia trained on digital chest X-ray images is proposed, which could aid the radiologists in their decision making process. A novel approach based on a weighted classifier is introduced, which combines the weighted predictions from the state-of-the-art deep learning models such as ResNet18, Xception, InceptionV3, DenseNet121, and MobileNetV3 in an optimal way. This approach is a supervised learning approach in which the network predicts the result based on the quality of the dataset used. Transfer learning is used to fine-tune the deep learning models to obtain higher training and validation accuracy. Partial data augmentation techniques are employed to increase the training dataset in a balanced way. The proposed weighted classifier is able to outperform all the individual models. Finally, the model is evaluated, not only in terms of test accuracy, but also in the AUC score. The final proposed weighted classifier model is able to achieve a test accuracy of 98.43% and an AUC score of 99.76 on the unseen data from the Guangzhou Women and Children’s Medical Center pneumonia dataset. Hence, the proposed model can be used for a quick diagnosis of pneumonia and can aid the radiologists in the diagnosis process.

scholarly journals Building an Otoscopic screening prototype tool using deep learning

2019 ◽  
Vol 48 (1) ◽  
Author(s):  
Devon Livingstone ◽  
Aron S. Talai ◽  
Justin Chau ◽  
Nils D. Forkert
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Primary Care Providers ◽  
Deep Convolutional Neural Network ◽  
Training Dataset ◽  
Great Success ◽  
Care Providers ◽  
Tympanostomy Tubes ◽  
Tympanic Membranes

Abstract Background Otologic diseases are often difficult to diagnose accurately for primary care providers. Deep learning methods have been applied with great success in many areas of medicine, often outperforming well trained human observers. The aim of this work was to develop and evaluate an automatic software prototype to identify otologic abnormalities using a deep convolutional neural network. Material and methods A database of 734 unique otoscopic images of various ear pathologies, including 63 cerumen impactions, 120 tympanostomy tubes, and 346 normal tympanic membranes were acquired. 80% of the images were used for the training of a convolutional neural network and the remaining 20% were used for algorithm validation. Image augmentation was employed on the training dataset to increase the number of training images. The general network architecture consisted of three convolutional layers plus batch normalization and dropout layers to avoid over fitting. Results The validation based on 45 datasets not used for model training revealed that the proposed deep convolutional neural network is capable of identifying and differentiating between normal tympanic membranes, tympanostomy tubes, and cerumen impactions with an overall accuracy of 84.4%. Conclusion Our study shows that deep convolutional neural networks hold immense potential as a diagnostic adjunct for otologic disease management.

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