scholarly journals Role of NMDAR plasticity in a computational model of synaptic memory

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ekaterina D. Gribkova ◽  
Rhanor Gillette

AbstractA largely unexplored question in neuronal plasticity is whether synapses are capable of encoding and learning the timing of synaptic inputs. We address this question in a computational model of synaptic input time difference learning (SITDL), where N‐methyl‐d‐aspartate receptor (NMDAR) isoform expression in silent synapses is affected by time differences between glutamate and voltage signals. We suggest that differences between NMDARs’ glutamate and voltage gate conductances induce modifications of the synapse’s NMDAR isoform population, consequently changing the timing of synaptic response. NMDAR expression at individual synapses can encode the precise time difference between signals. Thus, SITDL enables the learning and reconstruction of signals across multiple synapses of a single neuron. In addition to plausibly predicting the roles of NMDARs in synaptic plasticity, SITDL can be usefully applied in artificial neural network models.

2011 ◽  
Vol 403-408 ◽  
pp. 3587-3593
Author(s):  
T.V.K. Hanumantha Rao ◽  
Saurabh Mishra ◽  
Sudhir Kumar Singh

In this paper, the artificial neural network method was used for Electrocardiogram (ECG) pattern analysis. The analysis of the ECG can benefit from the wide availability of computing technology as far as features and performances as well. This paper presents some results achieved by carrying out the classification tasks by integrating the most common features of ECG analysis. Four types of ECG patterns were chosen from the MIT-BIH database to be recognized, including normal sinus rhythm, long term atrial fibrillation, sudden cardiac death and congestive heart failure. The R-R interval features were performed as the characteristic representation of the original ECG signals to be fed into the neural network models. Two types of artificial neural network models, SOM (Self- Organizing maps) and RBF (Radial Basis Function) networks were separately trained and tested for ECG pattern recognition and experimental results of the different models have been compared. The trade-off between the time consuming training of artificial neural networks and their performance is also explored. The Radial Basis Function network exhibited the best performance and reached an overall accuracy of 93% and the Kohonen Self- Organizing map network reached an overall accuracy of 87.5%.


Author(s):  
Fathi Ahmed Ali Adam, Mahmoud Mohamed Abdel Aziz Gamal El-Di

The study examined the use of artificial neural network models to predict the exchange rate in Sudan through annual exchange rate data between the US dollar and the Sudanese pound. This study aimed to formulate the models of artificial neural networks in which the exchange rate can be predicted in the coming period. The importance of the study is that it is necessary to use modern models to predict instead of other classical models. The study hypothesized that the models of artificial neural networks have a high ability to predict the exchange rate. Use models of artificial neural networks. The most important results ability of artificial neural networks models to predict the exchange rate accurately, Form MLP (1-1-1) is the best model chosen for that purpose. The study recommended the development of the proposed model for long-term forecasting.


2018 ◽  
Vol 2018 ◽  
pp. 1-15
Author(s):  
Tahmineh Adili ◽  
Zohreh Rostamnezhad ◽  
Ali Chaibakhsh ◽  
Ali Jamali

Burner failures are common abnormal conditions associated with industrial fired heaters. Preventing from economic loss and major equipment damages can be attained by compensating the lost heat due to burners’ failures, which can be possible by defining appropriate setpoints to rearrange the firing rates for healthy burners. In this study, artificial neural network models were developed for estimating the appropriate setpoints for the combustion control system to recover an industrial fired-heater furnace from abnormal conditions. For this purpose, based on an accurate high-order mathematical model, constrained nonlinear optimization problems were solved using the genetic algorithm. For different failure scenarios, the best possible excess firing rates for healthy burners to recover the furnace from abnormal conditions were obtained and data were recorded for training and testing stages. The performances of the developed neural steady-state models were evaluated through simulation experiments. The obtained results indicated the feasibility of the proposed technique to deal with the failures in the combustion system.


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