scholarly journals Metabolism modulation in rat tissues in response to point specificity of electroacupuncture

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Der-Yen Lee ◽  
Yu-Rung Jiu ◽  
Ching-Liang Hsieh
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Rat Heart ◽  
Metabolite Profiling ◽  
Electric Stimulation ◽  
Heart Diseases ◽  
Sham Acupuncture ◽  
Rat Tissues ◽  
Pericardium Meridian ◽  
Stomach Meridian

AbstractZusanli (ST36) and Neiguan (PC6) are acupoints along two meridians. To demonstrate point specificity, we investigated the effects of ST36 and PC6 in electroacupuncture (EA)-treated rats. The rats were subjected to sham acupuncture at ST36 without electric stimulation, EA at ST36, or EA at PC6. Heart and stomach tissues were collected for metabolite profiling. Each type of stimulation resulted in a different metabolite composition in the rat heart and stomach tissues. In the heart tissues, EA at ST36 affected a wider range of metabolite pathways than did EA at PC6, whereas similar numbers of metabolites in the stomach tissues were affected by EA at ST36 and PC6. The pathways affected by EA at ST36 differed from those affected by EA at PC6, and a group of common metabolites were reversely regulated by these two acupoints. This study demonstrated point specificity effectively modulated metabolism in rat heart and stomach tissues. The results indicate that heart stimulation may be connected to the stomach through the pericardium meridian (as described in traditional Chinese medicine), explaining why acupuncture applied to the stomach meridian can be an alternative treatment for gastric and heart diseases.

Revealing the potential pharmacological mechanism of traditional Chinese medicine by integrating metabolite profiling of Q-marker and network pharmacology, prim-O-glucosylcimifugin as an example

2021 ◽  
Author(s):  
Fengxiang Zhang ◽  
Yu-Lin-Lan Yuan ◽  
Shuang-shuang Cui ◽  
Guanhua Wang ◽  
Rui-man Li
Keyword(s):  
Quality Control ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Metabolite Profiling ◽  
Network Pharmacology ◽  
Clinical Effects ◽  
Pharmacological Mechanism

Along with the definite clinical effects, traditional Chinese medicine (TCM) increasingly gains worldwide attention. Quality control marker (Q-marker) is always used to confirm the primary effects of herbs or TCM....

A New Medical Trend in China

1975 ◽  
Vol 03 (03) ◽  
pp. 213-221 ◽  
Author(s):  
C. P. Li
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Heart Diseases ◽  
Current Medical ◽  
Biomedical Science ◽  
New Approach ◽  
X Ray ◽  
Chinese Herbal ◽  
Anti Cancer

Chinese biomedical scientists are now developing a new approach to medicine by combining traditional Chinese medicine and Western biomedical science. This is the current medical trend in China. Some significant results have already been achieved. For instance, in treating fractures the traditional dexterity in coaxing broken ends of bones into alignment has been successfully adopted, and x-ray has been used to check whether there was accurate bone union. Heart diseases are treated with Western drugs in combination with Chinese herbal medicine, and the results are encouraging. Ancient theories such as Fu Chen Pei Ben (to strengthen the patient's vitality) are applied, for instance, in cancer therapy, i.e., to stimulate the patient's appetite and to improve his general condition with herbs while being treated with Western anti-cancer remedies. However, the Chinese admit that this process has only just begun.

On Dermatomes, Meridians and Points: Results of a Quasiexperimental Study

2014 ◽  
Vol 32 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Max Sánchez-Araujo ◽  
Ana J Luckert-Barela ◽  
Nathalia Sánchez ◽  
Juan Torres ◽  
Jesus Eloy Conde
Keyword(s):  
Clinical Trials ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Vertical Distribution ◽  
Reference Value ◽  
Sham Acupuncture ◽  
The Other ◽  
Spinal Nerves ◽  
Clinical Indications ◽  
Horizontal Pattern

Background Traditional Chinese medicine (TCM) meridians and points run vertically, reflecting their function in the Zhang-Fu system (meridian pattern). However, the trunk's spinal nerves show a traverse orientation, or a ‘horizontal pattern’. Objective The aim of the present work was to evaluate, via a cognitive quasiexperiment, whether the clinical indications of the points on the trunk are associated with their meridian function or with their innervation and visceral–somatic connection. Methods The points in each dermatome of the trunk were considered crosswise, regardless of their meridians. The clinical indications for each point were differentiated into two mutually exclusive categories: (a) vertical distribution effect (VDE) or ‘meridian pattern’, when indications were quite different regarding the indications for the other points on the dermatome; and (b) transverse distribution effects (TDE) or ‘horizontal pattern’, represented by mainly local or segmental indications except for Shu-Mu points. After observing that the proportions between both categories often exceeded 60% in pilot samples, 60% was adopted as the reference value. Results A total of 22 dermatomes accommodated 148 points with 809 indications, of which 189 indications (23.4%) exhibited VDE features, whereas 620 (76.6%) exhibited TDE features. Conclusions A TDE/VDE ratio of 3 : 1 implies that the clinical indications for the points of any dermatome on the torso are similar, regardless of their meridians, and suggests that most of the indications for trunk points involve a ‘horizontal pattern’ due to their neurobiological nature. These findings may help in understanding acupuncture's neurobiology and clarify some confusing results of clinical research, for example, excluding sham acupuncture as an inert intervention for future clinical trials.

scholarly journals A Mass Spectrometry Based Metabolite Profiling Workflow for Selecting Abundant Specific Markers and Their Structurally Related Multi-Component Signatures in Traditional Chinese Medicine Multi‐Herb Formulae

2020 ◽  
Vol 11 ◽  
Author(s):  
Joëlle Houriet ◽  
Pierre-Marie Allard ◽  
Emerson Ferreira Queiroz ◽  
Laurence Marcourt ◽  
Arnaud Gaudry ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quality Control ◽  
Chinese Medicine ◽  
High Resolution ◽  
Traditional Chinese Medicine ◽  
Secondary Metabolites ◽  
Metabolite Profiling ◽  
Specific Marker ◽  
Feature Maps ◽  
Starting Point

In Traditional Chinese Medicine (TCM), herbal preparations often consist of a mixture of herbs. Their quality control is challenging because every single herb contains hundreds of components (secondary metabolites). A typical 10 herb TCM formula was selected to develop an innovative strategy for its comprehensive chemical characterization and to study the specific contribution of each herb to the formula in an exploratory manner. Metabolite profiling of the TCM formula and the extract of each single herb were acquired with liquid chromatography coupled to high-resolution mass spectrometry for qualitative analyses, and to evaporative light scattering detection (ELSD) for semi-quantitative evaluation. The acquired data were organized as a feature-based molecular network (FBMN) which provided a comprehensive view of all types of secondary metabolites and their occurrence in the formula and all single herbs. These features were annotated by combining MS/MS-based in silico spectral match, manual evaluation of the structural consistency in the FBMN clusters, and taxonomy information. ELSD detection was used as a filter to select the most abundant features. At least one marker per herb was highlighted based on its specificity and abundance. A single large-scale fractionation from the enriched formula enabled the isolation and formal identification of most of them. The obtained markers allowed an improved annotation of associated features by manually propagating this information through the FBMN. These data were incorporated in the high-resolution metabolite profiling of the formula, which highlighted specific series of related components to each individual herb markers. These series of components, named multi-component signatures, may serve to improve the traceability of each herb in the formula. Altogether, the strategy provided highly informative compositional data of the TCM formula and detailed visualizations of the contribution of each herb by FBMN, filtered feature maps, and reconstituted chromatogram traces of all components linked to each specific marker. This comprehensive MS-based analytical workflow allowed a generic and unbiased selection of specific and abundant markers and the identification of multiple related sub-markers. This exploratory approach could serve as a starting point to develop more simple and targeted quality control methods with adapted marker specificity selection criteria to given TCM formula.

Does Prior Acupuncture Exposure Affect Perception of Blinded Real Or Sham Acupuncture?

2014 ◽  
Vol 32 (2) ◽  
pp. 155-159 ◽  
Author(s):  
Caitlin R Dilli ◽  
Rebecca Childs ◽  
Julie Berk ◽  
M K Christian ◽  
Nancy Nguyen ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Outpatient Clinic ◽  
Acupuncture Treatment ◽  
Sham Acupuncture ◽  
Colorado School ◽  
The Real ◽  
Recent Exposure ◽  
Real Acupuncture

Objective To determine if acupuncture-exposed and naïve participants differ in their perceptions of real and sham acupuncture under blinded conditions. Methods The setting was an outpatient clinic at the Colorado School of Traditional Chinese Medicine. Participants were between the ages of 18 and 90 years. Acupuncture-exposed participants had at least five prior acupuncture treatments, with one treatment in the month prior to the study date. Acupuncture-naïve participants had experienced no prior acupuncture treatments. Participants with dementia, cognitive impairment, or neuropathy were excluded. In total, 61 acupuncture-exposed and 59 acupuncture-naïve participants were blindfolded and received either real acupuncture or toothpick sham acupuncture treatment. Following treatment, participants completed a questionnaire rating the realness of the acupuncture and were asked how they made this determination. We used a previously developed scale rating treatments from 1 (definitely real needle) to 5 (definitely imitation needle) to assess outcome. Results Perceptions of the real treatment were rated as more real than sham treatments for all participants. Further analysis revealed that prior acupuncture exposure did not influence ratings of real treatments, but exposed participants rated sham treatments as significantly less real than naïve participants. Conclusions Acupuncture-naïve and exposed participants both reported different perceptions of real and sham acupuncture using a blindfolded toothpick protocol. This suggests that future trials should carefully monitor participant perceptions of treatments received, even for naïve individuals. Differences between groups further suggest that participants with significant and/or recent exposure to real acupuncture may introduce bias to blinded clinical acupuncture trials.

Sign in / Sign up

Export Citation Format

Share Document