scholarly journals Targeted neuromodulation of pelvic floor nerves in aging and multiparous rabbits improves continence

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ana G. Hernandez-Reynoso ◽  
Dora L. Corona-Quintanilla ◽  
Kenia López-García ◽  
Ana A. Horbovetz ◽  
Francisco Castelán ◽  
...  
Keyword(s):  
Pelvic Floor ◽  
Nerve Injury ◽  
Pelvic Floor Muscle ◽  
Muscular Contraction ◽  
Urethral Pressure ◽  
Female Population ◽  
Electron Microscopy Analysis ◽  
Microscopy Analysis ◽  
Proportional Increase ◽  
Myelin Thickness

AbstractPelvic floor muscle stretch injury during pregnancy and birth is associated with the incidence of stress urinary incontinence (SUI), a condition that affects 30–60% of the female population and is characterized by involuntary urine leakage during physical activity, further exacerbated by aging. Aging and multiparous rabbits suffer pelvic nerve and muscle damage, resulting in alterations in pelvic floor muscular contraction and low urethral pressure, resembling SUI. However, the extent of nerve injury is not fully understood. Here, we used electron microscopy analysis of pelvic and perineal nerves in multiparous rabbits to describe the extent of stretch nerve injury based on axon count, axon size, myelin-to-axon ratio, and elliptical ratio. Compared to young nulliparous controls, mid-age multiparous animals showed an increase in the density of unmyelinated axons and in myelin thickness in both nerves, albeit more significant in the bulbospongiosus nerve. This revealed a partial but sustained damage to these nerves, and the presence of some regenerated axons. Additionally, we tested whether electrical stimulation of the bulbospongiosus nerve would induce muscle contraction and urethral closure. Using a miniature wireless stimulator implanted on this perineal nerve in young nulliparous and middle age multiparous female rabbits, we confirmed that these partially damaged nerves can be acutely depolarized, either at low (2–5 Hz) or medium (10–20 Hz) frequencies, to induce a proportional increase in urethral pressure. Evaluation of micturition volume in the mid-age multiparous animals after perineal nerve stimulation, effectively reversed a baseline deficit, increasing it 2-fold (p = 0.02). These results support the notion that selective neuromodulation of pelvic floor muscles might serve as a potential treatment for SUI.

Pelvic floor muscle training in women with a history of breast cancer

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 19-22
Author(s):  
Inna A Apolikhina ◽  
Valerii V Rodionov ◽  
Anna S Seialova ◽  
Aina S Saidova ◽  
Irina A Gukasian
Keyword(s):  
Breast Cancer ◽  
Pelvic Floor ◽  
Pelvic Floor Muscle ◽  
Combined Treatment ◽  
Social Activity ◽  
Pelvic Floor Muscles ◽  
Prospective Clinical Study ◽  
Female Population ◽  
Surgical Interventions

Relevance. The issue of pelvic floor muscle dysfunction (PFMD) is common in female population. It causes severe moral suffering and reduces both social activity and a quality of patient’s life. In this regard PFMD management with modern methods for training of pelvic floor muscles using devices is the "first line" method. Aim. To study treatment effectiveness and a quality of life in women with PFMD followed radical treatment for breast cancer (BC). Outcomes and methods. A prospective clinical study on clinical efficacy of a biofeedback method in combination with electrical stimulation of pelvic floor muscles using a device “Urostim” in patients with mild PFMD followed combined treatment fpr BC was carried out at Department of Aesthetic Gynecology of V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology. The study included 15 postmenopausal women. Results. It was established that 10 sessions of pelvic floor muscles training in a mode of biofeedback result in beneficial effects on for all clinical indicators. Conclusion. PFMD treatment by training of pelvic floor muscles using devices is one of the most promising ways to reduce surgical interventions number in urogynecology and to provide a rehabilitation of women who had surgery for BC.

scholarly journals Pelvic floor muscle function in a general female population in relation with age and parity and the relation between voluntary and involuntary contractions of the pelvic floor musculature

2009 ◽  
Vol 20 (12) ◽  
pp. 1497-1504 ◽  
Author(s):  
Marijke C. Ph. Slieker-ten Hove ◽  
Annelies L. Pool-Goudzwaard ◽  
Marinus J. C. Eijkemans ◽  
Regine P. M. Steegers-Theunissen ◽  
Curt W. Burger ◽  
...  
Keyword(s):  
Pelvic Floor ◽  
Muscle Function ◽  
Pelvic Floor Muscle ◽  
Pelvic Floor Musculature ◽  
Female Population ◽  
Pelvic Floor Muscle Function

Material analysis techniques using the ion mill

1996 ◽  
Vol 54 ◽  
pp. 1034-1035
Author(s):  
J. P. Benedict ◽  
R. M. Anderson ◽  
S. J. Klepeis
Keyword(s):  
Polished Surface ◽  
Surface Material ◽  
Analysis Techniques ◽  
Material Analysis ◽  
Optical Inspection ◽  
Electron Microscopy Analysis ◽  
Microscopy Analysis ◽  
Argon Ions ◽  
The Impact ◽  
Scanning Electron

Ion mills equipped with flood guns can perform two important functions in material analysis; they can either remove material or deposit material. The ion mill holder shown in Fig. 1 is used to remove material from the polished surface of a sample for further optical inspection or SEM ( Scanning Electron Microscopy ) analysis. The sample is attached to a pohshing stud type SEM mount and placed in the ion mill holder with the polished surface of the sample pointing straight up, as shown in Fig 2. As the holder is rotating in the ion mill, Argon ions from the flood gun are directed down at the top of the sample. The impact of Argon ions against the surface of the sample causes some of the surface material to leave the sample at a material dependent, nonuniform rate. As a result, the polished surface will begin to develop topography during milling as fast sputtering materials leave behind depressions in the polished surface.

Safety And Preliminary Efficacy of Magnetic Stimulation of Pelvic Floor with Hifem Technology in Urinary Incontinence

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Urinary Incontinence ◽  
Pelvic Floor ◽  
Magnetic Stimulation ◽  
Muscle Tone ◽  
Pelvic Floor Muscle ◽  
Neuromuscular Control ◽  
Ultrasound Elastography ◽  
Functional Evaluation ◽  
Muscle Injuries ◽  
Stimulation Of

Introduction: BTL EMSELLA™ utilizes High-Intensity Focused Electromagnetic technology (HIFEM) to cause deep pelvic floor muscles stimulation and restoration of the neuromuscular control. Key effectiveness is based on focused electromagnetic energy, in-depth penetration and stimulation of the entire pelvic floor area. A single BTL EMSELLA™ session brings thousands of supramaximal pelvic floor muscle contractions, which are extremely important in muscle reeducation of incontinent patients. Objective: Prospective study to evaluate the safety and preliminary effectiveness of the use of BTL EMSELLA magnetic stimulation in urinary incontinence. Method: Thirty-two patients with light and moderate urinary incontinence were recruited to perform 6 sessions of BTL EMSELLA during three weeks of initial treatment. Follow-up after three months. The patients received sessions lasting 28 minutes, completing the different treatment protocols. Initially the patients underwent a quality of life test before and after treatment, evaluation with advanced ultrasound using elastography to measure the initial tissue's elasticity and be able to compare after treatment, clinical functional evaluation and urodynamic test. Results: No adverse reactions were observed. All the patients finished the treatment sessions. Two patients reported increased pain after treatment in the first session corresponding to a VAS scale greater than 5 with duration greater than three hours. The treatment was highly satisfactory in 84,4% of the patients. After the first three months the improvement was maintained in 77% of the patients. No muscle injuries were observed. Elastographic changes and improvement of muscle tone were detected by advanced ultrasound (elastography) in 100% of patients. Conclusions: BTL EMSELLA is safe, well tolerated and effective for the treatment of mild and moderate urinary incontinence. The observed elastographic changes demonstrate the improvement of pelvic floor muscle tone after treatment. A reduction in the symptoms of urinary incontinence was demonstrated. Recommendations: Continue increasing the number of cases for research and increase the variables that we have decided to incorporate in the next research section such as MRI and pressure calculation.

Possibilities of using neodymium laser (Nd:YAG) in patients with concomitant diseases which are accompanied by pathological discharge from the genital tract

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (4) ◽  
pp. 75-81
Author(s):  
Olga A. Pauzina ◽  
Inna A. Apolikhina ◽  
Darya A. Malyshkina
Keyword(s):  
Drug Therapy ◽  
Pelvic Floor ◽  
Genital Tract ◽  
Vaginal Discharge ◽  
Muscle Tone ◽  
Pelvic Floor Muscle ◽  
Pelvic Floor Dysfunction ◽  
Vaginal Wall ◽  
Neodymium Laser ◽  
Frequent Relapses

Background. Pathological vaginal discharge is the most common disorder in women after giving birth who have vaginal relaxation syndrome and vaginal wall prolapse, as well as in women during menopause. To date, there are no clear treatment regimens for mixed vulvovaginal infections, and the use of only drug therapy in patients with pelvic organ prolapse and genitourinary syndrome of menopause in combination with diseases which are accompanied by pathological vaginal discharge does not give a long lasting result and is characterized by frequent relapses. In this regard, the use of laser methods in combination with drug therapy may lead to the recovery of vaginal microbiocenosis and a decrease in the number of relapses of diseases which are accompanied by pathological discharge from the genital tract. Results. Description. This article presents a clinical case and description of the experience of using a neodymium laser for the treatment of a patient with recurrent mixed vulvovaginitis, 2nd- degree vaginal wall prolapse, loss of pelvic floor muscle tone, vaginal relaxation syndrome and sexual dysfunction using neodymium laser. The woman received 3 procedures of exposure to a neodymium laser with an interval of 2830 days. After 3 procedures of exposure to a neodymium laser, the patient has a good clinical efficacy in the recovery of vaginal microbiocenosis. Conclusions. An innovative technique of exposure to Nd:YAG neodymium laser in the practice of a gynecologist has shown high clinical efficiency in the treatment of not only pelvic floor dysfunction, but also mixed vulvovaginitis. And, despite this aspect of the use of laser technologies requires further study, we can use a neodymium laser in combination with traditional drug therapy to treat diseases which are accompanied by pathological discharge from the genital tract in cases of ineffective drug monotherapy and frequent relapses.

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