Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease

AbstractWe performed pupillometer testing on 132 patients with Parkinson’s disease, stratified into two groups according to the disease stage. Neurological examinations and pupillometry were performed in the ON state. Patients in the Hoehn and Yahr stages 1 and 2 comprised the early group, and patients in stages 3–5 formed the late group. We performed age- and sex-matched (2:1) propensity score matching to compensate for the effect of age on pupil light reflex. Eight pupillometer parameters were measured and compared between the two groups. After the propensity score matching, the early group had 64 patients and the late group had 32 patients. The late group had a longer disease duration and took a higher levodopa equivalent dose than the early group. The constriction velocity (P = 0.006) and maximum constriction velocity (P = 0.005) were significantly faster in the early group than in the late group. Pupil size, minimum diameter, and dilation velocity were similar in both groups. The pupillary contraction velocity decreased with the disease progression, suggesting that the progression of Parkinson’s disease could be identified by the pupil constriction velocity.

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Analysis of pupillometer results according to motor symptom severity in patients with Parkinson’s disease

10.21203/rs.3.rs-556868/v1 ◽

2021 ◽

Author(s):

Sooyeoun You ◽

Jeong-Ho Hong ◽

Joonsang Yoo

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Propensity Score ◽

Propensity Score Matching ◽

Motor Symptom ◽

Early Group ◽

Minimum Diameter ◽

Pupil Light Reflex ◽

Pupil Constriction ◽

Late Group

Abstract We performed pupillometer testing on 132 patients with Parkinson’s disease, stratified into two groups according to the disease severity. Neurological examinations and pupillometry were performed in the ON state. Patients in the Hoehn and Yahr stages 1 and 2 comprised the early group, and patients in stages 3-5 formed the late group. We performed age- and sex-matched (2:1) propensity score matching to compensate for the effect of age on pupil light reflex. Eight pupillometer parameters were measured and compared between the two groups. After the propensity score matching, the early group had 64 patients and the late group had 32 patients. The late group had a longer disease duration and took a higher levodopa equivalent dose than the early group. The constriction velocity (P=0.006) and maximum constriction velocity (P=0.005) were significantly faster in the early group than in the late group. Pupil size, minimum diameter, and dilation velocity were similar in both groups. The pupillary contraction velocity decreased with the disease progression, suggesting that the progression of Parkinson’s disease could be identified by the pupil constriction velocity.

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A prospective, controlled study of non-motor effects of subthalamic stimulation in Parkinson’s disease: results at the 36-month follow-up

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2019-322614 ◽

2020 ◽

Vol 91 (7) ◽

pp. 687-694 ◽

Cited By ~ 3

Author(s):

Stefanie Theresa Jost ◽

Anna Sauerbier ◽

Veerle Visser-Vandewalle ◽

Keyoumars Ashkan ◽

Monty Silverdale ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Propensity Score ◽

Propensity Score Matching ◽

Controlled Study ◽

Group Differences ◽

Change Scores ◽

Motor Effects ◽

Stn Dbs

ObjectiveTo examine 36-month effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on non-motor symptoms (NMS) compared with standard-of-care medical treatment (MED) in Parkinson’s disease (PD).MethodsHere we report the 36-month follow-up of a prospective, observational, controlled, international multicentre study of the NILS cohort. Assessments included NMSScale (NMSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). Propensity score matching resulted in a pseudo-randomised sub-cohort balancing baseline demographic and clinical characteristics between the STN-DBS and MED groups. Within-group longitudinal outcome changes were analysed using Wilcoxon signed-rank and between-group differences of change scores with Mann-Whitney U test. Strength of clinical responses was quantified with Cohen’s effect size. In addition, bivariate correlations of change scores were explored.ResultsPropensity score matching applied on the cohort of 151 patients (STN-DBS n=67, MED n=84) resulted in a well-balanced sub-cohort including 38 patients per group. After 36 months, STN-DBS significantly improved NMSS, PDQ-8, SCOPA-motor examination and -complications and reduced LEDD. Significant between-group differences, all favouring STN-DBS, were found for NMSS, SCOPA-motor complications, LEDD (large effects), motor examination and PDQ-8 (moderate effects). Furthermore, significant differences were found for the sleep/fatigue, urinary (large effects) and miscellaneous NMSS domains (moderate effects). NMSS total and PDQ-8 change scores correlated significantly.ConclusionsThis study provides Class IIb evidence for beneficial effects of STN-DBS on NMS at 36-month follow-up which also correlated with quality of life improvements. This highlights the importance of NMS for DBS outcomes assessments.

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Metabolic Syndrome and Parkinson's Disease Incidence: A Nationwide Study Using Propensity Score Matching

Metabolic Syndrome and Related Disorders ◽

10.1089/met.2020.0060 ◽

2020 ◽

Author(s):

Ji-Hye Roh ◽

Sangjin Lee ◽

Jeong-Hyun Yoon

Keyword(s):

Parkinson’S Disease ◽

Metabolic Syndrome ◽

Parkinson's Disease ◽

Propensity Score ◽

Propensity Score Matching ◽

Disease Incidence ◽

Nationwide Study

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Multiclass machine learning classification of functional brain images for Parkinson's disease stage prediction

Statistical Analysis and Data Mining The ASA Data Science Journal ◽

10.1002/sam.11480 ◽

2020 ◽

Vol 13 (5) ◽

pp. 508-523 ◽

Cited By ~ 1

Author(s):

Guan‐Hua Huang ◽

Chih‐Hsuan Lin ◽

Yu‐Ren Cai ◽

Tai‐Been Chen ◽

Shih‐Yen Hsu ◽

...

Keyword(s):

Machine Learning ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Stage ◽

Brain Images ◽

Functional Brain ◽

Machine Learning Classification

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High-resolution ultrasound changes of the vagus nerve in idiopathic Parkinson’s disease (IPD): a possible additional index of disease

Neurological Sciences ◽

10.1007/s10072-021-05183-5 ◽

2021 ◽

Author(s):

F. Sartucci ◽

T. Bocci ◽

M. Santin ◽

P. Bongioanni ◽

G. Orlandi

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

High Resolution ◽

Vagus Nerve ◽

Imaging Modality ◽

Disease Stage ◽

Motor Nucleus ◽

Idiopathic Parkinson’S Disease ◽

Idiopathic Parkinson's Disease ◽

Additional Index

Abstract Background and rationale Histopathological studies revealed degeneration of the dorsal motor nucleus of the vagus nerve (VN) early in the course of idiopathic Parkinson’s disease (IPD). Degeneration of VN axons should be detectable by high-resolution ultrasound (HRUS) as a thinning of the nerve trunk. In order to establish if the VN exhibits sonographic signs of atrophy in IPD, we examined patients with IPD compared with age-matched controls. Material and methods We measured the caliber (cross-sectional area, CSA) and perimeter of the VN in 20 outpatients with IPD (8 females and 12 males; mean age 73.0 + 8.6 years) and in age-matched controls using HRUS. Evaluation was performed by blinded raters using an Esaote MyLab Gamma device in conventional B-Mode with an 8–19 MHz probe. Results In both sides, the VN CSA was significantly smaller in IPD outpatients than in controls (right 2.37 + 0.91, left 1.87 + 1.35 mm2 versus 6.0 + 1.33, 5.6 + 1.26 mm2; p <0.001), as well as the perimeter (right 5.06 + 0.85, left 4.78 + 1.74 mm versus 8.87 + 0.86, 8.58 + 0.97 mm; p <0.001). There were no significant correlations between VN CSA and age, the Hoehn and Yahr scale, L-dopa therapy, and disease duration. Conclusion Our findings provide evidence of atrophy of the VNs in IPD patients by HRUS. Moreover, HRUS of the VN represent a non-invasive easy imaging modality of screening in IPD patients independent of disease stage and duration and an interesting possible additional index of disease.

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Migraine is related to an increased risk of Parkinson’s disease: A population-based, propensity score-matched, longitudinal follow-up study

Cephalalgia ◽

10.1177/0333102416630577 ◽

2016 ◽

Vol 36 (14) ◽

pp. 1316-1323 ◽

Cited By ~ 10

Author(s):

Hsin-I Wang ◽

Yu-Chun Ho ◽

Ya-Ping Huang ◽

Shin-Liang Pan

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Survival Rate ◽

Propensity Score ◽

Population Based ◽

Free Survival ◽

Follow Up Study ◽

Increased Risk ◽

Migraine Group

Background The association between migraine and Parkinson’s disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD. Methods A total of 41,019 subjects aged between 40 and 90 years with at least two ambulatory visits with a diagnosis of migraine in 2001 were enrolled in the migraine group. A logistic regression model that included age, sex, pre-existing comorbidities and socioeconomic status as covariates was used to compute the propensity score. The non-migraine group consisted of 41,019 propensity score-matched, randomly sampled subjects without migraine. The PD-free survival rate were estimated using the Kaplan–Meier method. Stratified Cox proportional hazard regression was used to estimate the effect of migraine on the risk of developing PD. Results During follow-up, 148 subjects in the migraine group and 101 in the non-migraine group developed PD. Compared to the non-migraine group, the hazard ratio of PD for the migraine group was 1.64 (95% confidence interval: 1.25–2.14, p = 0.0004). The PD-free survival rate for the migraine group was significantly lower than that for the non-migraine group ( p = 0.0041). Conclusions This study showed an increased risk of developing PD in patients with migraine.

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Telerehabilitation in Parkinson's disease: Influence of cognitive status

Dementia & Neuropsychologia ◽

10.1590/s1980-5764-2016dn1004012 ◽

2016 ◽

Vol 10 (4) ◽

pp. 327-332 ◽

Cited By ~ 2

Author(s):

Alice Estevo Dias ◽

João Carlos Papaterra Limongi ◽

Wu Tu Hsing ◽

Egberto Reis Barbosa

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Status ◽

Disease Stage ◽

Voice Rehabilitation ◽

Voice Treatment ◽

Technological Competence ◽

Yahr Scale ◽

Invaluable Tool ◽

Remote Therapy

ABSTRACT Background: The need for efficacy in voice rehabilitation in patients with Parkinson's disease is well established. Given difficulties traveling from home to treatment centers, the use of telerehabilitation may represent an invaluable tool for many patients. Objective: To analyze the influence of cognitive performance on acceptance of telerehabilitation. Methods: Fifty patients at stages 2-4 on the Hoehn-Yahr scale, aged 45-87 years old, with cognitive scores of19-30 on the Mini-Mental State Examination, and 4-17 years of education were enrolled. All patients were submitted to evaluation of voice intensity pre and post in-person treatment with the Lee Silverman Voice Treatment (LSVT) and were asked to fill out a questionnaire regarding their preferences between two options of treatment and evaluating basic technological competence. Results: Comparisons between pre and post-treatment values showed a mean increase of 14dBSPL in vocal intensity. When asked about potential acceptance to participate in future telerehabilitation, 38 subjects agreed to take part and 12 did not. For these two groups, 26% and 17% self-reported technological competence, respectively. Agreement to engage in remote therapy was positively associated with years of education and cognitive status. Conclusion: Responses to the questionnaire submitted after completion of traditional in-person LSVT showed that the majority of patients (76%) were willing to participate in future telerehabilitation. Age, gender, disease stage and self-reported basic technological skills appeared to have no influence on the decision, whereas other factors such as cognitive status and higher school education were positively associated with acceptance of the new therapy approach.

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FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON

Human Care Journal ◽

10.32883/hcj.v5i1.649 ◽

2020 ◽

Vol 5 (1) ◽

pp. 343

Author(s):

Attiya Istarini ◽

Yuliarni Syafrita ◽

Restu Susanti

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Age At Onset ◽

Motor Symptom ◽

Disease Stage ◽

Motor Symptoms ◽

Research Subjects ◽

Cross Sectional ◽

Duration Of Disease ◽

Cross Sectional Design

Background: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some factors that influence motor symptoms in Parkinson's disease.Methods: This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values <0.05 were considered statistically significant.Results: This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p <0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.Conclusions: There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.

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