scholarly journals Dynamic changes of scleral spur length in different accommodation stimuli states

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Liugui Chen ◽  
Wei Jin ◽  
Xinlei Hao ◽  
Xuejie Li ◽  
Yiqiao Xing
Keyword(s):  
Optical Coherence Tomography ◽  
Receiver Operating Characteristic ◽  
Trabecular Meshwork ◽  
Operating Characteristic ◽  
Roc Curves ◽  
Ciliary Muscle ◽  
Dynamic Changes ◽  
Swept Source ◽  
Variable Distance ◽  
Spur Length

AbstractThis study aimed to evaluate the scleral spur length (SSL) in response to different accommodation stimuli states, as well as the correlation with Schlemm’s canal (SC) and trabecular meshwork (TM). 74 children were recruited for this study. The 0D, − 4D, and − 8.0 D accommodation stimuli state was achieved by looking at a variable distance optotype. The ciliary muscle (CM), scleral spur (SS), SC, and TM were imaged by swept-source optical coherence tomography. The SSL (Method III) increased significantly from 221.56 ± 30.74 μm at base state to 234.99 ± 30.11 μm at − 4D accommodation stimuli state (p = 0.028) and increased to 250.09 ± 29.87 μm at − 8D accommodation stimuli state (p = 0.011). Method III had the largest areas under receiver operating characteristic (ROC) curves (0.798, 95% CI 0.721–0.875). Moreover, CM 1, SC, and trabecular meshwork length (TML) were significantly correlated with SSL (Method III) (p < 0.05). These findings suggest that the contractile ability and compliance of the SS play an important role in maintaining the morphology of the SC. Moreover, the force of accommodation regulates the SC size by increasing the length of SS.

scholarly journals Dynamic Changes of Scleral Spur Length In Different Accommodation States

2021 ◽  
Author(s):  
Liugui Chen ◽  
Wei Jin ◽  
Xinlei Hao ◽  
Xuejie Li ◽  
Yiqiao Xing
Keyword(s):  
Optical Coherence Tomography ◽  
Trabecular Meshwork ◽  
Roc Curves ◽  
Ciliary Muscle ◽  
Schlemm’S Canal ◽  
Dynamic Changes ◽  
Swept Source ◽  
Schlemm's Canal ◽  
Variable Distance ◽  
Spur Length

Abstract This study aimed to evaluate the scleral spur length in response to different accommodation stimuli states, as well as the correlation with Schlemm’s canal and trabecular meshwork. 74 children were recruited for this study. The 0D, -4D, and − 8.0 D accommodation state was stimulated by looking at a variable distance optotype. The ciliary muscle, scleral spur, Schlemm’s canal, and trabecular meshwork were imaged by swept-source optical coherence tomography. The scleral spur length increased with accommodation stimulation (p < 0.05). Method I was 127.97 ± 20.32 µm, 138.29 ± 20.11 µm, and 150.73 ± 21.75 µm at 0D, -4D and − 8D, respectively. Method II was 158.15 ± 19.97 µm, 168.47 ± 18.72 µm, and 179.79 ± 20.83 µm at 0D, -4D and − 8D, respectively. Method III was 221.56 ± 30.74 µm, 234.99 ± 30.11 µm, and 250.09 ± 29.87 µm at 0D, -4D and − 8D, respectively. Method III had the largest areas under ROC curves (0.798, 95% CI 0.721–0.875). Moreover, ciliary muscle 1, Schlemm’s canal, and trabecular meshwork length were significantly correlated with SSL (Method III) (p < 0.05). These findings suggest that the contractile ability and compliance of the scleral spur play an important role in maintaining the morphology of the SC. Moreover, the force of accommodation regulates the SC size by increasing the length of SS.

scholarly journals The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm’s Canal: An in vivo Swept-Source Optical Coherence Tomography Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhangliang Li ◽  
Ziqi Meng ◽  
Wenyong Qu ◽  
Xiuyuan Li ◽  
Pingjun Chang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Trabecular Meshwork ◽  
Crystalline Lens ◽  
Ciliary Muscle ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Schlemm's Canal ◽  
The Relationship ◽  
Healthy Participants

Purpose: To evaluate the effects of age on the morphologies of the crystalline lens, ciliary muscle (CM), Schlemm’s canal (SC), and trabecular meshwork (TM) using swept-source optical coherence tomography (SS-OCT).Methods: Images of the crystalline lens and iridocorneal angle were obtained in healthy participants’ eyes using SS-OCT. Morphological parameters of the crystalline lens, CM, and TM/SC were measured, and the relationship between these parameters and age was evaluated.Results: A total of 62 healthy participants were enrolled, with an age range of 7–79 years. With adjustments for the effects of axial length and sex, both the nasal and temporal SC cross-sectional areas (CSA) and the cross-sectional area of the CM (CMA), distance from the scleral spur to the inner apex of the ciliary muscle (IA-SS), and nasal SC volume were negatively correlated with age (P ≤ 0.041). Meanwhile, the lens thickness (LT) (P &lt; 0.001) and lens vault (LV) (P &lt; 0.001) were positively correlated with age, and the radius of the curvature of the anterior lens (ALR) was negatively correlated with age (P &lt; 0.001).Conclusion: Increasing age was associated with a thicker crystalline lens, a steeper anterior lens curvature, an anteriorly located and smaller CM, and a narrower SC.Clinical Trial Registration:https://register.clinicaltrials.gov/prs/app/action/Select Protocol?sid=S000A3JZ&amp;selectaction=Edit&amp;uid=U00019K7&amp;ts=4&amp;cx=-c5xxp8, identifier [NCT04576884].

Use of Receiver Operating Characteristic (ROC) Curves to Evaluate Computer Confidence Threshold and Clinical Performance in the Diagnosis of Appendicitis

1978 ◽  
Vol 17 (03) ◽  
pp. 157-161 ◽  
Author(s):  
F. T. De Dombal ◽  
Jane C. Horrocks
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Clinical Performance ◽  
Roc Curves ◽  
Final Diagnosis ◽  
Confidence Threshold ◽  
Computer Aided ◽  
Computer Confidence ◽  
Overall Performance ◽  
Receiver Operating

This paper uses simple receiver operating characteristic (ROC) curves (i) to study the effect of varying computer confidence of threshold levels and (ii) to evaluate clinical performance in the diagnosis of acute appendicitis. Over 1300 patients presenting to five centres with abdominal pain of short duration were studied in varying detail. Clinical and computer-aided diagnostic predictions were compared with the »final« diagnosis. From these studies it is concluded the simplistic setting of a 50/50 confidence threshold for the computer program is as »good« as any other. The proximity of a computer-aided system changed clinical behaviour patterns; a higher overall performance level was achieved and clinicians performance levels became associated with the »mildly conservative« end of the computers ROC curve. Prior forecasts of over-confidence or ultra-caution amongst clinicians using the computer-aided system have not been fulfilled.

scholarly journals MicroRNAs-1299, -126-3p and -30e-3p as Potential Diagnostic Biomarkers for Prediabetes

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 949
Author(s):  
Cecil J. Weale ◽  
Don M. Matshazi ◽  
Saarah F. G. Davids ◽  
Shanel Raghubeer ◽  
Rajiv T. Erasmus ◽  
...  
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Predictive Ability ◽  
Roc Curves ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Oral Glucose ◽  
Cross Sectional ◽  
Receiver Operating

This cross-sectional study investigated the association of miR-1299, -126-3p and -30e-3p with and their diagnostic capability for dysglycaemia in 1273 (men, n = 345) South Africans, aged >20 years. Glycaemic status was assessed by oral glucose tolerance test (OGTT). Whole blood microRNA (miRNA) expressions were assessed using TaqMan-based reverse transcription quantitative-PCR (RT-qPCR). Receiver operating characteristic (ROC) curves assessed the ability of each miRNA to discriminate dysglycaemia, while multivariable logistic regression analyses linked expression with dysglycaemia. In all, 207 (16.2%) and 94 (7.4%) participants had prediabetes and type 2 diabetes mellitus (T2DM), respectively. All three miRNAs were significantly highly expressed in individuals with prediabetes compared to normotolerant patients, p < 0.001. miR-30e-3p and miR-126-3p were also significantly more expressed in T2DM versus normotolerant patients, p < 0.001. In multivariable logistic regressions, the three miRNAs were consistently and continuously associated with prediabetes, while only miR-126-3p was associated with T2DM. The ROC analysis indicated all three miRNAs had a significant overall predictive ability to diagnose prediabetes, diabetes and the combination of both (dysglycaemia), with the area under the receiver operating characteristic curve (AUC) being significantly higher for miR-126-3p in prediabetes. For prediabetes diagnosis, miR-126-3p (AUC = 0.760) outperformed HbA1c (AUC = 0.695), p = 0.042. These results suggest that miR-1299, -126-3p and -30e-3p are associated with prediabetes, and measuring miR-126-3p could potentially contribute to diabetes risk screening strategies.

scholarly journals Diagnostic performances of manual and automated reticulocyte parameters in anaemic cats

2017 ◽  
Vol 20 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Saverio Paltrinieri ◽  
Marco Fossati ◽  
Valentina Menaballi
Keyword(s):  
Receiver Operating Characteristic ◽  
Sensitivity And Specificity ◽  
Operating Characteristic ◽  
Positive Likelihood Ratio ◽  
Roc Curves ◽  
Blood Samples ◽  
Production Index ◽  
Instrumental Measurement ◽  
Sensitivity Specificity ◽  
Reticulocyte Production

Objectives The objective of this study was to evaluate the diagnostic performances of manual and instrumental measurement of reticulocyte percentage (Ret%), reticulocyte number (Ret#) and reticulocyte production index (RPI) to differentiate regenerative anaemia (RA) from non-regenerative anaemia (NRA) in cats. Methods Data from 106 blood samples from anaemic cats with manual counts (n = 74; 68 NRA, six RA) or instrumental counts of reticulocytes (n = 32; 25 NRA, seven RA) collected between 1995 and 2013 were retrospectively analysed. Sensitivity, specificity and positive likelihood ratio (LR+) were calculated using either cut-offs reported in the literature or cut-offs determined from receiver operating characteristic (ROC) curves. Results All the reticulocyte parameters were significantly higher in cats with RA than in cats with NRA. All the ROC curves were significantly different ( P <0.001) from the line of no discrimination, without significant differences between the three parameters. Using the cut-offs published in literature, the Ret% (cut-off: 0.5%) was sensitive (100%) but not specific (<75%), the RPI (cut-off: 1.0) was specific (>92%) but not sensitive (<15%), and the Ret# (cut-off: 50 × 10³/µl) had a sensitivity and specificity >80% and the highest LR+ (manual count: 14; instrumental count: 6). For all the parameters, sensitivity and specificity approached 100% using the cut-offs determined by the ROC curves. These cut-offs were higher than those reported in the literature for Ret% (manual: 1.70%; instrumental: 3.06%), lower for RPI (manual: 0.39; instrumental: 0.59) and variably different, depending on the method (manual: 41 × 10³/µl; instrumental: 57 × 10³/µl), for Ret#. Using these cut-offs, the RPI had the highest LR+ (manual: 22.7; instrumental: 12.5). Conclusions and relevance This study indicated that all the reticulocyte parameters may confirm regeneration when the pretest probability is high, while when this probability is moderate, RA should be identified using the RPI providing that cut-offs <1.0 are used.

SOME EFFECTS OF IMAGE SEGMENTATION ON SUBSPACE-BASED AND COVARIANCE-BASED DETECTION OF ANOMALOUS SUB-PIXEL MATERIALS

2008 ◽  
Vol 18 (02) ◽  
pp. 349-367
Author(s):  
CHRISTOPHER GITTINS ◽  
DAISEI KONNO ◽  
MICHAEL HOKE ◽  
ANTHONY RATKOWSKI
Keyword(s):  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Roc Curves ◽  
Synthetic Spectrum ◽  
Ratio Test ◽  
Probability Of False Alarm ◽  
Near Ir ◽  
Data Segmentation ◽  
Material Detection ◽  
Receiver Operating

In this paper we assess the effect that clustering pixels into spectrally-similar background types, for example, soil, vegetation, and water in hyperspectral visible/near-IR/SWIR imagery, prior to applying a detection methodology has on material detection statistics. Specifically, we examine the effects of data segmentation on two statistically-based detection metrics, the Subspace Generalized Likelihood Ratio Test (Subspace GLRT) and the Adaptive Cosine Estimator (ACE), applied to a publicly-available AVIRIS datacube augmented with a synthetic material spectrum in selected pixels. The use of synthetic spectrum-augmented data enables quantitative comparison of Subspace-GLRT and ACE using Receiver Operating Characteristic (ROC) curves. For all cases investigated, Receiver Operating Characteristic (ROC) curves generated using ACE were as good as or superior to those generated using Subspace-GLRT. The favorability of ACE over Subspace-GLRT was more pronounced as the synthetic spectrum mixing fraction decreased. For probabilities of detection in the range of 50-80%, segmentation reduced the probability of false alarm by a factor of 3–5 when using ACE. In contrast, segmentation had no apparent effect on detection statistics using Subspace-GLRT, in this example.

Assessment of trabecular meshwork width using swept source optical coherence tomography

2013 ◽  
Vol 251 (6) ◽  
pp. 1587-1592 ◽  
Author(s):  
Tin A. Tun ◽  
Mani Baskaran ◽  
Ce Zheng ◽  
Lisandro M. Sakata ◽  
Shamira A. Perera ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Trabecular Meshwork ◽  
Optical Coherence ◽  
Swept Source
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