scholarly journals Analysis on the healing of gastrointestinal ulceration by using Hemospray

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christoph R. Werner ◽  
Lena Brücklmeier ◽  
Thomas Kratt ◽  
Nisar P. Malek ◽  
Bence Sipos ◽  
...  
Keyword(s):  
Animal Model ◽  
Gastrointestinal Tract ◽  
Healing Process ◽  
Mucosal Healing ◽  
Pathophysiological Mechanism ◽  
Lower Gastrointestinal Tract ◽  
Significant Difference ◽  
Hemostatic Powder ◽  
Collagen Layer ◽  
Gastrointestinal Ulceration

AbstractHealing of gastrointestinal ulcers after Hemospray application was reported in literature. The pathophysiological mechanism of action of hemostatic powders is not elucidated so far. A prospective animal model was performed to evaluate the effect of Hemospray application on the healing process of artificially induced ulcers of the upper and lower gastrointestinal tract. In 10 pigs, 20 ulcers were created in each the upper and the lower gastrointestinal tract by endoscopic mucosal resection. 50% of the pigs were immediately treated with Hemospray application, the others were not treated. Ulcer size was measured endoscopically on day 0, 2, and 7. On day 7 the ulcers were histopathological evaluated for capillary ingrowth and the thickness of the collagen layer. After 7 days the sizes of the ulcers decreased significantly (stomach: − 22.8% with Hemospray application, − 19% without Hemospray application; rectum: − 50.8% with Hemospray application, − 49.5% without Hemospray application; p = 0.005–0.037), but without significant difference between both groups. This study shows no significant effect of the hemostatic powder Hemospray on ulcer healing in the upper and lower gastrointestinal tract compared with untreated controls, neither harmful nor beneficial. However, some trends merit further trials in patients and may indicate a possible mechanism of accelerated mucosal healing.

scholarly journals Experimental model of the burn wound topical treatment

2003 ◽  
Vol 3 (4) ◽  
pp. 61-66
Author(s):  
Amra Čabaravdić ◽  
Irfan Zulić ◽  
Zakira Mornjaković ◽  
Mirjana Mijanović ◽  
Fahir Bečić
Keyword(s):  
Animal Model ◽  
Clinical Symptoms ◽  
Healing Process ◽  
Surrounding Tissue ◽  
Control Group ◽  
Wound Healing Process ◽  
Herbal Preparation ◽  
Burn Wound ◽  
Experimental Animals ◽  
Significant Difference

AbstractBACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burninducement and effects of the ointment containing natural plants on the process of burn healing.MATERIAL AND METHODS:Burn wounds were experimentally induced in two species of experimental animals which were treated with topically applied herbal preparation with concomitant monitoring of the healing process. Experimental groups (1) of 15 animals each (mice and rats), while control group (2) of 10 animals each (mice and rats) that were not being treated with herbal ointment. After the hair removal, burn was induced on the back of animals by heated brass seal. Different clinical symptoms including oedema of surrounding tissue, redness, exudation, size of the burn surface, histological and microbiological findings were monitored on the days 1, 3, 7, 14 and 21. A statistically significant difference was observed throughout descriptive statistics and paired Student's t-test.CONCLUSION:Physiological healing processes of the acute burn wound following the topical application of herbal preparation can be monitored on the utilized animal model. A three-week treatment resulted in the 90% of completed epithelization in both animal species, indicating the effectiveness of topically applied herbal preparation.

scholarly journals The effect of capsicum frutescens-l to transient receptor potential vinaloid-1, toll like receptors (tlr-4) and interleukin 1 beta (il-1β) on periodontitis

2017 ◽  
Vol 2 (2) ◽  
pp. 114
Author(s):  
Jenny Sunariani ◽  
Latief Mooduto ◽  
Yuliati Yuliati
Keyword(s):  
Animal Model ◽  
Transient Receptor Potential ◽  
Healing Process ◽  
Receptor Potential ◽  
Male Rats ◽  
Laboratory Research ◽  
Transient Receptor Potential Vanilloid ◽  
Capsicum Frutescens ◽  
Significant Difference ◽  
Transient Receptor

Objective: Indonesia has many kinds of useful herbs, which are often used as species such as chili, pepper or cayenne pepper (Capsicum frutescens L). Previous study showed topical capsaicin can be used as a therapy to cure pain due to inflammation. Small concentrations of capsaicin can attenuate cytokines in the inflammatory process. Capsaicin studies in animal model showed activation of the transient receptor potential vanilloid-1. Capsaicin can decrease various cytokines such as IL-6, IL-12, IL-1β, and increase IL-10. Capsaicin is a natural agonist for transient receptor potential vanilloid-1. The aim of this study is to prove the effect of capsaicin on transient receptor potential vanilloid-1 expression and TNF-α and TLR-4 toward pain.Material and Methods: An experimental laboratory research used animal model Wistar male rats (Rattus novegicus) induced with Aggregatibacter actinomycetemcomitans serotype b and green chili extract (Capsicum frutescens L.) with a dose of 0.0912 mg/kg/day was applied to surface of the gingiva on maxillary first molar for 7 days. An immunohistochemical examination was conducted to see the density of transient receptor potential vanilloid-1, and the expression of TLR-4 and IL-1β in the mucosal tissues of the oral cavity.Results: There were significant differences in the applications of Capsicum frutescens L. with increasing of TRPV ligand-1 and IL-1β (p < 0.05), while the TLR-4 (p > 0.05) showed a significant difference to TRPV-1 and IL-1β. There is no significant difference to TLR-4.Conclusion: Capsaicin can increase TRPV-1 and decrease IL-1β but did not affect the TLR-4. Capsaicin can be used to decrease pain and accelerate healing process in periodontitis.

P.165 ASSOCIATION BETWEEN UPPER AND LOWER GASTROINTESTINAL TRACT LESIONS

2010 ◽  
Vol 42 ◽  
pp. S161
Author(s):  
L. Elli ◽  
F. Somalvico ◽  
R. Rivolta ◽  
F. Fregoni
Keyword(s):  
Gastrointestinal Tract ◽  
Lower Gastrointestinal Tract

673 Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S193-S193
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
H Ebru ◽  
Ayvazoglu Soy ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Introduction Burn is one of the most severe traumas that causes coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burn may affect the patient’s survival and reduce the complications that may be seen. In the present study we aimed effects of subcutaneous ozone injection on second degree burn wound. Methods A total of 72 Sprague-Dawley male rats included in the study were divided randomly into three groups (control group (CG), silver sulfadiazine group (SG), ozone group (OG)) and each group was divided randomly two subgroups (as sacrificed on d7 and on d14).A deep second degree scald burns were created on the lower back. In CG subcutaneous 0.9% serum saline was injected daily into the burn area. In SG, burns were dressed with silver sulfadiazine daily and in OG subcutaneous ozone was injected daily into the burn area. Tissue hydroxyproline level measurement and histopathological evaluation were done. Results When the groups were compared in terms of weight change, no significant difference was found on the 7th and 14th days. In the evaluation made in terms of tissue hydroxyproline, tissue hydroxyproline level in OG was found to be significantly higher on both the 7th and 14th days (p &lt; 0.001). In histopathological evaluations, it was determined that wound healing in OG was significantly higher than in the other groups. Conclusions According to the results, subcutaneous ozone therapy is more effective than silver sulphadiazine in the healing process of second-degree burn wounds and it can be safely used in the treatment of burn wounds.

scholarly journals Virome biogeography in the lower gastrointestinal tract of rhesus macaques with chronic diarrhea

Virology ◽  
2019 ◽  
Vol 527 ◽  
pp. 77-88 ◽  
Author(s):  
Guoyan Zhao ◽  
Lindsay Droit ◽  
Margaret H. Gilbert ◽  
Faith R. Schiro ◽  
Peter J. Didier ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Chronic Diarrhea ◽  
Rhesus Macaques ◽  
Lower Gastrointestinal Tract
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