scholarly journals Transcription factor Znf2 coordinates with the chromatin remodeling SWI/SNF complex to regulate cryptococcal cellular differentiation

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Jianfeng Lin ◽  
Youbao Zhao ◽  
Aileen R. Ferraro ◽  
Ence Yang ◽  
Zachary A. Lewis ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chromatin Remodeling ◽  
Cellular Differentiation ◽  
Biological Function ◽  
Specific Factor ◽  
Promoter Regions ◽  
Forward Genetic Screen ◽  
Chromatin Remodeling Complex ◽  
Chromatin Remodeling Complexes ◽  
Ascomycetous Yeasts

AbstractCellular differentiation is instructed by developmental regulators in coordination with chromatin remodeling complexes. Much information about their coordination comes from studies in the model ascomycetous yeasts. It is not clear, however, what kind of information that can be extrapolated to species of other phyla in Kingdom Fungi. In the basidiomycete Cryptococcus neoformans, the transcription factor Znf2 controls yeast-to-hypha differentiation. Through a forward genetic screen, we identified the basidiomycete-specific factor Brf1. We discovered Brf1 works together with Snf5 in the SWI/SNF chromatin remodeling complex in concert with existent Znf2 to execute cellular differentiation. We demonstrated that SWI/SNF assists Znf2 in opening the promoter regions of hyphal specific genes, including the ZNF2 gene itself. This complex also supports Znf2 to fully associate with its target regions. Importantly, our findings revealed key differences in composition and biological function of the SWI/SNF complex in the two major phyla of Kingdom Fungi.

scholarly journals GBAF, a small BAF sub-complex with big implications: a systematic review

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Sarah M. Innis ◽  
Birgit Cabot
Keyword(s):  
Chromatin Remodeling ◽  
Cellular Differentiation ◽  
Complex Function ◽  
Therapeutic Interventions ◽  
Mammalian Development ◽  
Aberrant Expression ◽  
Chromatin Remodelers ◽  
Baf Complex ◽  
Chromatin Remodeling Complexes ◽  
Histone Modifying Enzymes

Abstract ATP-dependent chromatin remodeling by histone-modifying enzymes and chromatin remodeling complexes is crucial for maintaining chromatin organization and facilitating gene transcription. In the SWI/SNF family of ATP-dependent chromatin remodelers, distinct complexes such as BAF, PBAF, GBAF, esBAF and npBAF/nBAF are of particular interest regarding their implications in cellular differentiation and development, as well as in various diseases. The recently identified BAF subcomplex GBAF is no exception to this, and information is emerging linking this complex and its components to crucial events in mammalian development. Furthermore, given the essential nature of many of its subunits in maintaining effective chromatin remodeling function, it comes as no surprise that aberrant expression of GBAF complex components is associated with disease development, including neurodevelopmental disorders and numerous malignancies. It becomes clear that building upon our knowledge of GBAF and BAF complex function will be essential for advancements in both mammalian reproductive applications and the development of more effective therapeutic interventions and strategies. Here, we review the roles of the SWI/SNF chromatin remodeling subcomplex GBAF and its subunits in mammalian development and disease.

scholarly journals Akirin links Twist transcription factor activity with the Brahma chromatin remodeling complex during embryogenesis

2010 ◽  
Vol 344 (1) ◽  
pp. 489-490
Author(s):  
Scott J. Nowak ◽  
Hitoshi Aihara ◽  
Katie Gonzalez ◽  
Yutaka Nibu ◽  
Mary K. Baylies
Keyword(s):  
Transcription Factor ◽  
Chromatin Remodeling ◽  
Transcription Factor Activity ◽  
Factor Activity ◽  
Chromatin Remodeling Complex

scholarly journals Phosphorylation of Williams Syndrome Transcription Factor by MAPK Induces a Switching between Two Distinct Chromatin Remodeling Complexes

2009 ◽  
Vol 284 (47) ◽  
pp. 32472-32482 ◽  
Author(s):  
Hiroyuki Oya ◽  
Atsushi Yokoyama ◽  
Ikuko Yamaoka ◽  
Ryoji Fujiki ◽  
Masayoshi Yonezawa ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chromatin Remodeling ◽  
Williams Syndrome ◽  
Chromatin Remodeling Complexes

scholarly journals Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes.

2013 ◽  
Vol 288 (42) ◽  
pp. 30508-30508
Author(s):  
Hiroyuki Oya ◽  
Atsushi Yokoyama ◽  
Ikuko Yamaoka ◽  
Ryoji Fujiki ◽  
Masayoshi Yonezawa ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Chromatin Remodeling ◽  
Williams Syndrome ◽  
Chromatin Remodeling Complexes

scholarly journals SWR1 Chromatin Remodeling Complex: A Key Transcriptional Regulator in Plants

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1621 ◽  
Author(s):  
Mohammad Aslam ◽  
Beenish Fakher ◽  
Bello Hassan Jakada ◽  
Shijiang Cao ◽  
Yuan Qin
Keyword(s):  
Chromatin Remodeling ◽  
Dna Accessibility ◽  
Physiological Processes ◽  
Chromatin Remodeling Complex ◽  
Damage Repair ◽  
Eukaryotic Chromatin ◽  
Chromatin Remodeling Complexes ◽  
Cellular Machinery ◽  
Environmental Responses

The nucleosome is the structural and fundamental unit of eukaryotic chromatin. The chromatin remodeling complexes change nucleosome composition, packaging and positioning to regulate DNA accessibility for cellular machinery. SWI2/SNF2-Related 1 Chromatin Remodeling Complex (SWR1-C) belongs to the INO80 chromatin remodeling family and mainly catalyzes the exchange of H2A-H2B with the H2A.Z-H2B dimer. The replacement of H2A.Z into nucleosomes affects nucleosome stability and chromatin structure. Incorporation of H2A.Z into the chromatin and its physiochemical properties play a key role in transcriptional regulation during developmental and environmental responses. In Arabidopsis, various studies have uncovered several pivotal roles of SWR1-C. Recently, notable progress has been achieved in understanding the role of SWR1-C in plant developmental and physiological processes such as DNA damage repair, stress tolerance, and flowering time. The present article introduces the SWR1-C and comprehensively reviews recent discoveries made in understanding the function of the SWR1 complex in plants.

scholarly journals FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells

2021 ◽  
Author(s):  
Nadia Habel ◽  
Najla El-Hachem ◽  
Frédéric Soysouvanh ◽  
Hanene Hadhiri-Bzioueche ◽  
Serena Giuliano ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Target Gene ◽  
Tumor Development ◽  
Melanoma Cells ◽  
Complex Activity ◽  
Cellular Processes ◽  
Chromatin Remodeling Complex ◽  
Chromatin Remodeling Complexes ◽  
Proliferation And Invasion

AbstractUbiquitination by serving as a major degradation signal of proteins, but also by controlling protein functioning and localization, plays critical roles in most key cellular processes. Here, we show that MITF, the master transcription factor in melanocytes, controls ubiquitination in melanoma cells. We identified FBXO32, a component of the SCF E3 ligase complex as a new MITF target gene. FBXO32 favors melanoma cell migration, proliferation, and tumor development in vivo. Transcriptomic analysis shows that FBXO32 knockdown induces a global change in melanoma gene expression profile. These include the inhibition of CDK6 in agreement with an inhibition of cell proliferation and invasion upon FBXO32 silencing. Furthermore, proteomic analysis identifies SMARC4, a component of the chromatin remodeling complexes BAF/PBAF, as a FBXO32 partner. FBXO32 and SMARCA4 co-localize at loci regulated by FBXO32, such as CDK6 suggesting that FBXO32 controls transcription through the regulation of chromatin remodeling complex activity. FBXO32 and SMARCA4 are the components of a molecular cascade, linking MITF to epigenetics, in melanoma cells.

scholarly journals In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development in Drosophila melanogaster

2021 ◽  
Vol 22 (9) ◽  
pp. 4525
Author(s):  
Yuri Prozzillo ◽  
Stefano Cuticone ◽  
Diego Ferreri ◽  
Gaia Fattorini ◽  
Giovanni Messina ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Chromatin Remodeling ◽  
Cell Biology ◽  
Reverse Genetics ◽  
Developmentally Regulated ◽  
Chromatin Remodeling Complex ◽  
Chromatin Remodeling Complexes ◽  
Histone Modifying Enzymes ◽  
Classical Genetics

Chromatin organization is developmentally regulated by epigenetic changes mediated by histone-modifying enzymes and chromatin remodeling complexes. In Drosophila melanogaster, the Tip60 chromatin remodeling complex (dTip60) play roles in chromatin regulation, which are shared by evolutionarily-related complexes identified in animal and plants. Recently, it was found that most subunits previously assigned to the dTip60 complex are shared by two related complexes, DOM-A.C and DOM-B.C, defined by DOM-A and DOM-B isoforms, respectively. In this work, we combined classical genetics, cell biology, and reverse genetics approaches to further investigate the biological roles played during Drosophila melanogaster development by a number of subunits originally assigned to the dTip60 complex.

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