scholarly journals Upconversion optogenetic micro-nanosystem optically controls the secretion of light-responsive bacteria for systemic immunity regulation

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Chun Yang ◽  
Meihui Cui ◽  
Yingying Zhang ◽  
Huizhuo Pan ◽  
Jing Liu ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Optical Manipulation ◽  
Transplanted Tumors ◽  
New Strategy ◽  
B16f10 Tumor ◽  
Associated Functions ◽  
Inflammatory Bowel ◽  
Ifn Γ ◽  
Engineered Bacteria ◽  
Tgf Β1

AbstractChemical molecules specifically secreted into the blood and targeted tissues by intestinal microbiota can effectively affect the associated functions of the intestine especially immunity, representing a new strategy for immune-related diseases. However, proper ways of regulating the secretion metabolism of specific strains still remain to be established. In this article, an upconversion optogenetic micro-nanosystem was constructed to effectively regulate the specific secretion of engineered bacteria. The system included two major modules: (i) Modification of secretory light-responsive engineered bacteria. (ii) Optical sensing mediated by upconversion optogenetic micro-nanosystem. This system could regulate the efficient secretion of immune factors by engineered bacteria through optical manipulation. Inflammatory bowel disease and subcutaneously transplanted tumors were selected to verify the effectiveness of the system. Our results showed that the endogenous factor TGF-β1 could be controllably secreted to suppress the intestinal inflammatory response. Additionally, regulatory secretion of IFN-γ was promoted to slow the progression of B16F10 tumor.

scholarly journals Activation, Deficiency, and Reduced IFN-γ Production of Mucosal-Associated Invariant T Cells in Patients with Inflammatory Bowel Disease

2020 ◽  
Vol 12 (5) ◽  
pp. 422-434
Author(s):  
Jae Kyun Ju ◽  
Young-Nan Cho ◽  
Ki-Jeong Park ◽  
Han Deok Kwak ◽  
Hye-Mi Jin ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Ifn Γ ◽  
Invariant T Cells

Sphingomyelinase Inhibition Suggests a Possible New Strategy for the Treatment of Inflammatory Bowel Disease

2008 ◽  
Vol 3 (3) ◽  
pp. 218-225 ◽  
Author(s):  
Shinji Soeda ◽  
Akira Sakata ◽  
Takashi Ochiai ◽  
Kazuya Yasuda ◽  
Yukako Kuramoto ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
New Strategy ◽  
Inflammatory Bowel

scholarly journals Wnt/β-catenin activation epigenetically reprograms Regulatory T cells in IBD and progression to dysplasia.

2020 ◽  
Author(s):  
Fotini Gounari ◽  
Jasmin Quandt ◽  
Stephen Arnovitz ◽  
Leila Haghi ◽  
Janine Woehlk ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
T Cells ◽  
Regulatory T Cells ◽  
Functional Diversity ◽  
Bowel Disease ◽  
Elevated Expression ◽  
Inflammatory Bowel ◽  
Ifn Γ ◽  
Accessible Chromatin

Abstract The molecular and functional diversity of regulatory T-cells (Tregs) in health and in disease remains unclear. We previously described in colorectal cancer (CRC) patients a subpopulation of RORγt+ Tregs with elevated expression of β-catenin and pro-inflammatory properties. Here we observed progressive expansion of RORγt+ Tregs in inflammatory bowel disease (IBD) patients during inflammation and early dysplasia. Activating Wnt/β-catenin signaling in human and murine Tregs was sufficient to recapitulate the disease-associated increase in frequencies of RORγt+ Tregs expressing IL-17, IFN-γ, and TNFa. We found that binding of the β-catenin interacting partner, TCF-1, to DNA overlapped with Foxp3 binding at enhancer sites of pro-inflammatory pathway genes. Sustained Wnt/β-catenin activation induced newly accessible chromatin sites in these genes and upregulated their expression. These findings indicate that TCF-1 and Foxp3 together limit the expression of pro-inflammatory genes in Tregs. Activation of ꞵ-catenin signaling interferes with this function and promotes the disease-associated RORγt+ Treg phenotype.

Whole Food–Based Approaches to Modulating Gut Microbiota and Associated Diseases

2020 ◽  
Vol 11 (1) ◽  
pp. 119-143 ◽  
Author(s):  
Yanhui Han ◽  
Hang Xiao
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Fruits And Vegetables ◽  
Beneficial Effects ◽  
Associated Diseases ◽  
Associated Functions ◽  
Inflammatory Bowel ◽  
Whole Foods

Intake of whole foods, such as fruits and vegetables, may confer health benefits to the host. The beneficial effects of fruits and vegetables were mainly attributed to their richness in polyphenols and microbiota-accessible carbohydrates (MACs). Components in fruits and vegetables modulate composition and associated functions of the gut microbiota, whereas gut microbiota can transform components in fruits and vegetables to produce metabolites that are bioactive and important for health. The progression of multiple diseases, such as obesity and inflammatory bowel disease, is associated with diet and gut microbiota. Although the exact causality between these diseases and specific members of gut microbiota has not been well characterized, accumulating evidence supported the role of fruits and vegetables in modulating gut microbiota and decreasing the risks of microbiota-associated diseases. This review summarizes the latest findings on the effects of whole fruits and vegetables on gut microbiota and associated diseases.

scholarly journals Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Francesca Algieri ◽  
Alba Rodriguez-Nogales ◽  
M. Elena Rodriguez-Cabezas ◽  
Severiano Risco ◽  
M. Angeles Ocete ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Clinical Trials ◽  
Bowel Disease ◽  
Life Quality ◽  
Beneficial Effects ◽  
New Strategy ◽  
Inflammatory Bowel ◽  
Surgical Treatments

Crohn’s disease and ulcerative colitis are the two most common categories of inflammatory bowel disease (IBD), which are characterized by chronic inflammation of the intestine that comprises the patients’ life quality and requires sustained pharmacological and surgical treatments. Since their aetiology is not completely understood, nonfully efficient drugs have been developed and those that show effectiveness are not devoid of quite important adverse effects that impair their long-term use. Therefore, many patients try with some botanical drugs, which are safe and efficient after many years of use. However, it is necessary to properly evaluate these therapies to consider a new strategy for human IBD. In this report we have reviewed the main botanical drugs that have been assessed in clinical trials in human IBD and the mechanisms and the active compounds proposed for their beneficial effects.

Enhanced Expression of Transcription Factor GATA-4 in Inflammatory Bowel Disease and Its Possible Regulation by TGF-β1

2009 ◽  
Vol 29 (4) ◽  
pp. 444-453 ◽  
Author(s):  
Hanna Haveri ◽  
Merja Ashorn ◽  
Sari Iltanen ◽  
David B. Wilson ◽  
Leif C. Andersson ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Transcription Factor ◽  
Bowel Disease ◽  
Enhanced Expression ◽  
Inflammatory Bowel ◽  
Tgf Β1
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