scholarly journals Safety of long-term consumption of plant sterol esters-enriched spread

2003 ◽  
Vol 57 (5) ◽  
pp. 681-692 ◽  
Author(s):  
H F J Hendriks ◽  
E J Brink ◽  
G W Meijer ◽  
H M G Princen ◽  
F Y Ntanios
Keyword(s):  
2017 ◽  
Vol 20 (7) ◽  
pp. 659-666 ◽  
Author(s):  
Nur Fathonah Sadek ◽  
Nancy Dewi Yuliana ◽  
Endang Prangdimurti ◽  
Bambang Pontjo Priosoeryanto ◽  
Slamet Budijanto

2004 ◽  
Vol 134 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Yuguang Lin ◽  
Gert W. Meijer ◽  
Mario A. Vermeer ◽  
Elke A. Trautwein

PEDIATRICS ◽  
1976 ◽  
Vol 57 (1) ◽  
pp. 60-67
Author(s):  
M. Mellies ◽  
C. J. Glueck ◽  
C. Sweeney ◽  
R. W. Fallat ◽  
R. C. Tsang ◽  
...  

Plasma phytosterol (plant sterol) levels were studied in 26 infants on various commercial formulas, in 36 infants on breast or cow's milk formulas, in 101 normal and 22 hypercholesterolemic children on a free diet, and in 32 hypercholesterolemic children on a low-cholesterol diet. Commercial formulas, poor in animal fats and enriched with vegetable oils, and low-cholesterol, phytosterol-rich diets generally elevated total plasma phytosterol levels in infants and hypercholesterolemic children from normal mean levels of 2 mg/100 ml to about 9 mg/100 ml. The implications of long-term three- to five-fold elevations of the plasma phytosterols (campesterol, stigmasterol, β-sitosterol) in infancy and childhood are unknown. Watchful prospective analysis of plasma phytosterol levels may be useful, particularly in regards to otherwise unanticipated long-term effects of cholesterol-poor, phytosterol rich diets.


2011 ◽  
Vol 214 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Elton R. Kelly ◽  
Jogchum Plat ◽  
Ronald P. Mensink ◽  
Tos T.J.M. Berendschot

2006 ◽  
Vol 108 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Xianghe Meng ◽  
Peilong Sun ◽  
Qiuyue Pan ◽  
Zhongping Shi ◽  
Kai Yang ◽  
...  

Author(s):  
Helena Gylling ◽  
Tatu A Miettinen

Phytosterols are plant sterols, mainly campesterol and sitosterol, and their respective stanols (5α-saturated derivatives), which chemically resemble cholesterol. They are present in a normal diet and are absorbed proportionally to cholesterol, but to a much lesser extent, such that less than 0.1% of serum sterols are plant sterols. Phytosterols inhibit intestinal cholesterol absorption, and fat-soluble plant stanol esters were introduced as a functional food for lowering serum cholesterol in the early 1990s; plant sterol esters entered the market at the end of the 1990s. Inhibition of the intestinal absorption of cholesterol stimulates cholesterol synthesis, a factor which limits serum cholesterol lowering to about 10% with phytosterols. Enrichment of the diet with plant stanol esters reduces absorption and serum concentrations of both cholesterol and plant sterols, whereas enrichment of the diet with plant sterol esters, especially in combination with statins, lowers serum cholesterol but increases serum plant sterol levels. Recent studies have suggested that high-serum plant sterol levels may be associated with increased coincidence of coronary heart disease. Estimates of coronary heart disease reduction by 20-25% with plant sterols/stanols is based mainly on short-term studies. Long-term cholesterol lowering, needed for the prevention of coronary heart disease, may be successful with plant stanol esters, which lower serum cholesterol in both genders over at least a year.


2014 ◽  
Vol 6 ◽  
pp. 280-289 ◽  
Author(s):  
Mandana Amir Shaghaghi ◽  
Scott V. Harding ◽  
Peter J.H. Jones

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