IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

Obstructive Nephropathy ◽

Type I ◽

Receptor Kinase ◽

Alk5 Inhibitor

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

Cancer Research ◽

10.1158/0008-5472.can-06-2389 ◽

2007 ◽

Vol 67 (5) ◽

pp. 2351-2359 ◽

Cited By ~ 72

Author(s):

Eiji Suzuki ◽

Samuel Kim ◽

H.-Kam Cheung ◽

Michael J. Corbley ◽

Xiamei Zhang ◽

...

Keyword(s):

Growth Factor ◽

Tumor Growth ◽

Small Molecule ◽

Tumor Recurrence ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor

Inhibition of Gene Markers of Fibrosis with a Novel Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase in Puromycin-Induced Nephritis

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.082099 ◽

2005 ◽

Vol 313 (3) ◽

pp. 943-951 ◽

Cited By ~ 120

Author(s):

Eugene T. Grygielko ◽

William M. Martin ◽

Christopher Tweed ◽

Peter Thornton ◽

John Harling ◽

...

Keyword(s):

Growth Factor ◽

Type I ◽

Receptor Kinase ◽

Gene Markers

Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

Cancer Research ◽

10.1158/0008-5472.can-05-3565 ◽

2006 ◽

Vol 66 (13) ◽

pp. 6714-6721 ◽

Cited By ~ 137

Author(s):

Abhik Bandyopadhyay ◽

Joseph K. Agyin ◽

Long Wang ◽

Yuping Tang ◽

Xiufen Lei ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitor ◽

Skeletal Metastasis ◽

Type I ◽

Receptor Kinase

Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons

Journal of Neuroscience Research ◽

10.1002/jnr.22552 ◽

2010 ◽

Vol 89 (3) ◽

pp. 381-393 ◽

Cited By ~ 20

Author(s):

Nozomu Yoshioka ◽

Junko Kimura-Kuroda ◽

Taro Saito ◽

Koki Kawamura ◽

Shin-ichi Hisanaga ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor ◽

Injured Brain ◽

Β Receptor

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-0162 ◽

2006 ◽

Vol 12 (14) ◽

pp. 4315-4330 ◽

Cited By ~ 102

Author(s):

Rongrong Ge ◽

Vaishali Rajeev ◽

Partha Ray ◽

Edmund Lattime ◽

Susan Rittling ◽

...

Keyword(s):

Growth Factor ◽

Mammary Carcinoma ◽

Selective Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Mouse Mammary Carcinoma ◽

Inhibition Of Growth

Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5)

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.09.002 ◽

2015 ◽

Vol 93 ◽

pp. 599-613 ◽

Cited By ~ 29

Author(s):

Harun M. Patel ◽

Baljeet Sing ◽

Varun Bhardwaj ◽

Mahesh Palkar ◽

Mahamadhanif S. Shaikh ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Type I ◽

Receptor Kinase ◽

Design Synthesis

EW-7197, an oral transforming growth factor β type I receptor kinase inhibitor, for preventing peritoneal adhesion formation in a rat model

Surgery ◽

10.1016/j.surg.2018.07.005 ◽

2018 ◽

Vol 164 (5) ◽

pp. 1100-1108 ◽

Cited By ~ 4

Author(s):

Jiaywei Tsauo ◽

Ho-Young Song ◽

Eun Young Choi ◽

Dae-Kee Kim ◽

Kun Yung Kim ◽

...

Keyword(s):

Growth Factor ◽

Rat Model ◽

Kinase Inhibitor ◽

Adhesion Formation ◽

Type I ◽

Receptor Kinase ◽

Peritoneal Adhesion ◽

Peritoneal Adhesion Formation

Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type I receptor kinase

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.09.058 ◽

2015 ◽

Vol 25 (22) ◽

pp. 5228-5231 ◽

Cited By ~ 9

Author(s):

Maddeboina Krishnaiah ◽

Cheng Hua Jin ◽

Yhun Yhong Sheen ◽

Dae-Kee Kim

Keyword(s):

Growth Factor ◽

Synthesis And Biological Evaluation

Biological Evaluation ◽

Type I ◽

Receptor Kinase ◽

186 TRANSFORMING GROWTH FACTOR-ß TYPE I RECEPTOR KINASE (ALK5) INHIBITOR ALLEVIATES FIBROSIS IN FIBROBLASTS DERIVED FROM HUMAN PEYRONIE'S PLAQUE

European Urology Supplements ◽

10.1016/s1569-9056(10)60190-x ◽

2010 ◽

Vol 9 (2) ◽

pp. 90-91

Author(s):

S. Piao ◽

M.J. Choi ◽

M. Tumurbaatar ◽

W.J. Kim ◽

H.R. Jin ◽

...

Keyword(s):

Growth Factor ◽

Type I ◽

Receptor Kinase ◽

Alk5 Inhibitor

Transforming Growth Factor (TGF)-β Type I Receptor Kinase (ALK5) Inhibitor Alleviates Profibrotic TGF-β1 Responses in Fibroblasts Derived from Peyronie's Plaque

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2010.01753.x ◽

2010 ◽

Vol 7 (10) ◽

pp. 3385-3395 ◽

Cited By ~ 22

Author(s):

Shuguang Piao ◽

Min Ji Choi ◽

Munkhbayar Tumurbaatar ◽

Woo Jean Kim ◽

Hai-Rong Jin ◽

...

Keyword(s):

Growth Factor ◽

Type I ◽

Receptor Kinase ◽

Alk5 Inhibitor ◽

Tgf Β1