186 TRANSFORMING GROWTH FACTOR-ß TYPE I RECEPTOR KINASE (ALK5) INHIBITOR ALLEVIATES FIBROSIS IN FIBROBLASTS DERIVED FROM HUMAN PEYRONIE'S PLAQUE

Type I ◽

Receptor Kinase ◽

Alk5 Inhibitor

IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

Kidney International ◽

10.1038/sj.ki.5001775 ◽

2006 ◽

Vol 70 (7) ◽

pp. 1234-1243 ◽

Cited By ~ 138

Author(s):

J.-A. Moon ◽

H.-T. Kim ◽

I.-S. Cho ◽

Y.Y. Sheen ◽

D.-K. Kim

Keyword(s):

Growth Factor ◽

Renal Fibrosis ◽

Obstructive Nephropathy ◽

Type I ◽

Receptor Kinase ◽

Alk5 Inhibitor

Transforming Growth Factor (TGF)-β Type I Receptor Kinase (ALK5) Inhibitor Alleviates Profibrotic TGF-β1 Responses in Fibroblasts Derived from Peyronie's Plaque

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2010.01753.x ◽

2010 ◽

Vol 7 (10) ◽

pp. 3385-3395 ◽

Cited By ~ 22

Author(s):

Shuguang Piao ◽

Min Ji Choi ◽

Munkhbayar Tumurbaatar ◽

Woo Jean Kim ◽

Hai-Rong Jin ◽

...

Keyword(s):

Growth Factor ◽

Type I ◽

Receptor Kinase ◽

Alk5 Inhibitor ◽

Tgf Β1

749: IN-1130, A Novel Transforming Growth Factor-S Type I Receptor Kinase (ALK5) Inhibitor, Regresses Fibrotic Plaque and Corrects Penile Curvature in a Rat Model of Peyronie's Disease

The Journal of Urology ◽

10.1016/s0022-5347(18)30989-3 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 251-251 ◽

Cited By ~ 2

Author(s):

Ji-Kan Ryu ◽

Shuguang Piao ◽

Hwa-Yean Shin ◽

Luwei Zhang ◽

Hairong Jin ◽

...

Keyword(s):

Growth Factor ◽

Rat Model ◽

Peyronie’S Disease ◽

Penile Curvature ◽

Type I ◽

Receptor Kinase ◽

Peyronie's Disease ◽

Alk5 Inhibitor

EW-7197, a Transforming Growth Factor-Beta Type I Receptor Kinase Inhibitor, Ameliorates Acquired Lymphedema in a Mouse Tail Model

Lymphatic Research and Biology ◽

10.1089/lrb.2018.0070 ◽

2020 ◽

Vol 18 (5) ◽

pp. 433-438

Author(s):

Sung-Hwan Yoon ◽

Kun Yung Kim ◽

Zhe Wang ◽

Jung-Hoon Park ◽

Sang Mun Bae ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Kinase Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Growth Factor Beta

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

Cancer Research ◽

10.1158/0008-5472.can-06-2389 ◽

2007 ◽

Vol 67 (5) ◽

pp. 2351-2359 ◽

Cited By ~ 72

Author(s):

Eiji Suzuki ◽

Samuel Kim ◽

H.-Kam Cheung ◽

Michael J. Corbley ◽

Xiamei Zhang ◽

...

Keyword(s):

Growth Factor ◽

Tumor Growth ◽

Small Molecule ◽

Tumor Recurrence ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor

Inhibition of Gene Markers of Fibrosis with a Novel Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase in Puromycin-Induced Nephritis

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.104.082099 ◽

2005 ◽

Vol 313 (3) ◽

pp. 943-951 ◽

Cited By ~ 120

Author(s):

Eugene T. Grygielko ◽

William M. Martin ◽

Christopher Tweed ◽

Peter Thornton ◽

John Harling ◽

...

Keyword(s):

Growth Factor ◽

Type I ◽

Receptor Kinase ◽

Gene Markers

Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor-β Type I Receptor Kinase Inhibitor

Cancer Research ◽

10.1158/0008-5472.can-05-3565 ◽

2006 ◽

Vol 66 (13) ◽

pp. 6714-6721 ◽

Cited By ~ 137

Author(s):

Abhik Bandyopadhyay ◽

Joseph K. Agyin ◽

Long Wang ◽

Yuping Tang ◽

Xiufen Lei ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitor ◽

Skeletal Metastasis ◽

Type I ◽

Receptor Kinase

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

Molecular Pharmacology ◽

10.1124/mol.62.1.58 ◽

2002 ◽

Vol 62 (1) ◽

pp. 58-64 ◽

Cited By ~ 442

Author(s):

N. J. Laping ◽

E. Grygielko ◽

A. Mathur ◽

S. Butter ◽

J. Bomberger ◽

...

Keyword(s):

Extracellular Matrix ◽

Growth Factor ◽

Kinase Activity ◽

Type I ◽

Receptor Kinase ◽

Tgf Β1

Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons

Journal of Neuroscience Research ◽

10.1002/jnr.22552 ◽

2010 ◽

Vol 89 (3) ◽

pp. 381-393 ◽

Cited By ~ 20

Author(s):

Nozomu Yoshioka ◽

Junko Kimura-Kuroda ◽

Taro Saito ◽

Koki Kawamura ◽

Shin-ichi Hisanaga ◽

...

Keyword(s):

Growth Factor ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Molecule Inhibitor ◽

Injured Brain ◽

Β Receptor

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-0162 ◽

2006 ◽

Vol 12 (14) ◽

pp. 4315-4330 ◽

Cited By ~ 102

Author(s):

Rongrong Ge ◽

Vaishali Rajeev ◽

Partha Ray ◽

Edmund Lattime ◽

Susan Rittling ◽

...

Keyword(s):

Growth Factor ◽

Mammary Carcinoma ◽

Selective Inhibitor ◽

Type I ◽

Receptor Kinase ◽

Mouse Mammary Carcinoma ◽

Inhibition Of Growth