scholarly journals The density difference between tissue and neural probes is a key factor for glial scarring

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Gustav Lind ◽  
Cecilia Eriksson Linsmeier ◽  
Jens Schouenborg
Keyword(s):  
Density Difference ◽  
Neural Probes ◽  
Key Factor ◽  
Glial Scarring

scholarly journals Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

2022 ◽  
Author(s):  
Elisabeth Otte ◽  
Andreas Vlachos ◽  
Maria Asplund
Keyword(s):  
Surgical Techniques ◽  
Microelectrode Arrays ◽  
Biological Response ◽  
Neural Probes ◽  
Clinical Neuroscience ◽  
The Past ◽  
Brain Interface ◽  
Glial Scarring ◽  
The Brain

AbstractNeural probes are sophisticated electrophysiological tools used for intra-cortical recording and stimulation. These microelectrode arrays, designed to penetrate and interface the brain from within, contribute at the forefront of basic and clinical neuroscience. However, one of the challenges and currently most significant limitations is their ‘seamless’ long-term integration into the surrounding brain tissue. Following implantation, which is typically accompanied by bleeding, the tissue responds with a scarring process, resulting in a gliotic region closest to the probe. This glial scarring is often associated with neuroinflammation, neurodegeneration, and a leaky blood–brain interface (BBI). The engineering progress on minimizing this reaction in the form of improved materials, microfabrication, and surgical techniques is summarized in this review. As research over the past decade has progressed towards a more detailed understanding of the nature of this biological response, it is time to pose the question: Are penetrating probes completely free from glial scarring at all possible?

scholarly journals An actuated neural probe architecture for reducing gliosis-induced recording degradation

2018 ◽  
Author(s):  
Travis L. Massey ◽  
Leane S. Kuo ◽  
Jiang Lan Fan ◽  
Michel M. Maharbiz
Keyword(s):  
Silicon On Insulator ◽  
Proof Of Concept ◽  
Signal Loss ◽  
Neural Probes ◽  
Neural Implant ◽  
Glial Scarring ◽  
Mechanical Proof ◽  
Minimize Tissue Damage ◽  
Target Depth ◽  
Brain Phantom

AbstractGlial encapsulation of chronically implanted neural probes inhibits recording and stimulation, and this signal loss is a significant factor limiting the clinical viability of most neural implant topologies for decades-long implantation. We demonstrate a mechanical proof of concept for silicon shank-style neural probes intended to minimize gliosis near the recording sites. Compliant whiskers on the edges of the probe fold inward to minimize tissue damage during insertion. Once implanted to the target depth and retracted slightly, these whiskers splay outward. The splayed tips, on which recording sites could be patterned, extend beyond the typical 50-100 micron radius of a glial scar. The whiskers are micron-scale to minimize or avoid glial scarring. Electrically inactive devices with whiskers of varying widths and curvature were designed and monolithically fabricated from a five-micron silicon-on-insulator (SOI) wafer, and their mechanical functionality was demonstrated in a 0.6% agar brain phantom. Deflection was plotted versus deflection speed, and those that were most compliant actuated successfully. This probe requires no preparation for use beyond what is typical for a shank-style silicon probe.

Attachment of oral bacteria to titanium surfaces: An SEM study

1994 ◽  
Vol 52 ◽  
pp. 468-469
Author(s):  
J. E. Laffoon ◽  
R. L. Anderson ◽  
J. C. Keller ◽  
C. D. Wu-Yuan
Keyword(s):  
Technical Problem ◽  
Titanium Implant ◽  
Oral Bacteria ◽  
Bacterial Cells ◽  
Thin Sections ◽  
Surface Ultrastructure ◽  
Sem Study ◽  
Key Factor ◽  
Titanium Surfaces

Titanium (Ti) dental implants have been used widely for many years. Long term implant failures are related, in part, to the development of peri-implantitis frequently associated with bacteria. Bacterial adherence and colonization have been considered a key factor in the pathogenesis of many biomaterial based infections. Without the initial attachment of oral bacteria to Ti-implant surfaces, subsequent polymicrobial accumulation and colonization leading to peri-implant disease cannot occur. The overall goal of this study is to examine the implant-oral bacterial interfaces and gain a greater understanding of their attachment characteristics and mechanisms. Since the detailed cell surface ultrastructure involved in attachment is only discernible at the electron microscopy level, the study is complicated by the technical problem of obtaining titanium implant and attached bacterial cells in the same ultra-thin sections. In this study, a technique was developed to facilitate the study of Ti implant-bacteria interface.Discs of polymerized Spurr’s resin (12 mm x 5 mm) were formed to a thickness of approximately 3 mm using an EM block holder (Fig. 1). Titanium was then deposited by vacuum deposition to a film thickness of 300Å (Fig. 2).

Forum: Morphological Awareness as a Key Factor in Language-Literacy Success for Academic Achievement

2020 ◽  
Vol 51 (3) ◽  
pp. 509-513
Author(s):  
Ashley Bourque Meaux ◽  
Julie A. Wolter ◽  
Ginger G. Collins
Keyword(s):  
Academic Achievement ◽  
Academic Success ◽  
Literacy Development ◽  
Morphological Awareness ◽  
Language And Literacy ◽  
Speech Language Pathologists ◽  
School Based ◽  
Literacy Success ◽  
Key Factor ◽  
Language And Literacy Development

Purpose This article introduces the Language, Speech, and Hearing Services in Schools Forum: Morphological Awareness as a Key Factor in Language-Literacy Success for Academic Achievement. The goal of this forum is to relate the influence morphological awareness (MA) has on overall language and literacy development with morphology acting as the “binding agent” between orthography, phonology, and semantics ( Perfetti, 2007 ) in assessment and intervention for school-aged children. Method This introduction provides a foundation for MA development and explores the influence MA has over the course of school-aged language and literacy development. Through summaries of the 11 articles in this forum, school-based speech-language pathologists will be able to convey the importance of MA to promote successful educational outcomes for kindergarten to adolescent students. The forum explores researcher-developed assessments used to help identify MA skill level in first- through eighth-grade students at risk for literacy failure to support instructional needs. The forum also provides school-based speech-language pathologists with details to design and implement MA interventions to support academic success for school-aged students with varying speech-language needs (e.g., dual language emersion, vocabulary development, reading comprehension) using various service delivery models (e.g., small group, classroom-based, intensive summer camps). Conclusion MA is effective in facilitating language and literacy development and as such can be an ideally focused on using multilinguistic approaches for assessment and intervention. The articles in this issue highlight the importance in assessment measures and intervention approaches that focus on students' MA to improve overall academic success in children of all ages and abilities.

1451: Positive Efect of Prostaglandin on Regulation of Prostate Blood Flow-Investigation of the Key Factor in the Signaling Pathway of The Prostate Blood Flow-

2005 ◽  
Vol 173 (4S) ◽  
pp. 393-393
Author(s):  
Bunzo Kashiwagi ◽  
Yasuhiro Shibata ◽  
Kazunari Ohki ◽  
Seiji Arai ◽  
Seijiro Honma ◽  
...  
Keyword(s):  
Blood Flow ◽  
Signaling Pathway ◽  
Flow Investigation ◽  
Key Factor

Does Attachment Shape Morality? Religiosity as a key factor in Moral Development

2011 ◽  
Author(s):  
Landon Ranck ◽  
Faith Clasby ◽  
Tor Ekstrom ◽  
Rebecca Ross ◽  
Claire Lawes ◽  
...  
Keyword(s):  
Moral Development ◽  
Key Factor

Comprehension of Sexual Consent as a Key Factor in the Perpetration of Sexual Aggression among College Men

2014 ◽  
Author(s):  
Peter Warren ◽  
Suzanne Swan ◽  
Christopher Allen
Keyword(s):  
Sexual Aggression ◽  
College Men ◽  
Sexual Consent ◽  
Key Factor
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