scholarly journals Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Santanu Hati ◽  
Sayantan Tripathy ◽  
Pratip Kumar Dutta ◽  
Rahul Agarwal ◽  
Ramprasad Srinivasan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Target Identification ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Cellular Target

Design, synthesis, and biological evaluation of novel morpholinated isatin–quinoline hybrids as potent anti‐breast cancer agents

2021 ◽  
Author(s):  
Atamjit Singh ◽  
Harneetpal Kaur ◽  
Saroj Arora ◽  
Preet Mohinder Singh Bedi
Keyword(s):  
Breast Cancer ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

2020 ◽  
Vol 36 (1) ◽  
pp. 270-285
Author(s):  
Wagdy M. Eldehna ◽  
Sara T. Al-Rashood ◽  
Tarfah Al-Warhi ◽  
Razan O. Eskandrani ◽  
Amal Alharbi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
In Silico ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
In Silico Studies ◽  
Gsk 3Β

scholarly journals Design, synthesis, and biological evaluation of new 6,N2-diaryl-1,3,5-triazine-2,4-diamines as anticancer agents selectively targeting triple negative breast cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (43) ◽  
pp. 25517-25528
Author(s):  
Ahmad Junaid ◽  
Felicia Phei Lin Lim ◽  
Edward R. T. Tiekink ◽  
Anton V. Dolzhenko
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Anticancer Agents ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
3D Qsar ◽  
Qsar Model ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

New highly potent and selective 6,N2-diaryl-1,3,5-triazine-2,4-diamines were designed and prepared using the 3D-QSAR model developed earlier.

Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer

2020 ◽  
Vol 205 ◽  
pp. 112648
Author(s):  
Dahong Yao ◽  
Chenyang Li ◽  
Jin Jiang ◽  
Jian Huang ◽  
Jinhui Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hdac Inhibitors ◽  
Pharmacokinetic Profile ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of 2-(phenoxymethyl)-5-phenyl-1,3,4-oxadiazole derivatives as anti-breast cancer agents

2019 ◽  
Vol 168 ◽  
pp. 1-10 ◽  
Author(s):  
K. Lakshmithendral ◽  
K. Saravanan ◽  
R. Elancheran ◽  
K. Archana ◽  
N. Manikandan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Oxadiazole Derivatives ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells

2017 ◽  
Vol 139 ◽  
pp. 305-324 ◽  
Author(s):  
Anver Basha Shaik ◽  
Garikapati Koteswara Rao ◽  
G. Bharath Kumar ◽  
Nibeditha Patel ◽  
Vangala Santhosh Reddy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Evaluation ◽  
Mtor Pathway ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, Synthesis and Biological Evaluation of Morpholinated Isatin-Quinoline Hybrids as Potential Anti-Breast Cancer Agents.

2021 ◽  
Author(s):  
Atamjit Singh ◽  
Komalpreet Kaur ◽  
Jaspreet Kaur ◽  
Puja Gulati ◽  
Amit Duggal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor Alpha ◽  
Fibroblast Cell ◽  
Biological Evaluation ◽  
Breast Cancer Cell Lines ◽  
Design Synthesis ◽  
M Phase ◽  
Almost All ◽  
Morpholine Derivatives ◽  
Mcf 7

Abstract Keeping in view the emerging need of potent and safer anti-breast cancer agents as well as pharmacological attributes of isatin, quinoline and morpholine derivatives, novel hydrazone linked morpholinated isatin-quinoline hybrids has been designed, synthesized and evaluated as anti-breast cancer agents. Synthesized hybrid compounds were preliminary screened against two breast cancer cell lines (MCF-7 and MDA-MB-231). Almost all synthetics showed potent inhibitory potential against hormone positive MCF-7 cells while inactive against hormone negative MDA-MB-231 cells. Potent compounds were further evaluated against L929 (noncancerous skin fibroblast) cell line and found highly selective for MCF-7 cells over L929 cells. Cell cycle analysis confirmed that most potent compound AS-4 (MCF-7: GI50 = 4.36 µM) cause mitotic arrest at G2/M-phase. Due to higher selectivity toward estrogen receptor alpha (ERα) dependent MCF-7 cells various binding interactions of AS-4 with ERα are also streamlined, suggesting the capability of AS-4 in completely blocking ERα. Overall study suggest that, AS-4 can act as a potential lead for further development of potent and safer anti-breast cancer agents.

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