Smoothened is a poor prognosis factor and a potential therapeutic target in glioma

: SET protein is a multi-functional oncoprotein that is ubiquitously expressed in most tumor cells. Dysregulation of SET has been associated with many types of cancer. Due to ever-accumulating evidence of its strong correlation with both poor prognosis and drug resistance, the targeting of SET is starting to be explored. SET is currently regarded as a potential target for cancer therapy, and several inhibitors are being developed for clinical trials. In this review, the physiological and pathological functions of SET, as well as its antagonists, will be discussed along with the prospects and challenges involved with translating SET inhibitors into bona fide therapeutic options.

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S-MDM4 mRNA overexpression indicates a poor prognosis and marks a potential therapeutic target in chronic lymphocytic leukemia

Cancer Science ◽

10.1111/cas.12008 ◽

2012 ◽

Vol 103 (12) ◽

pp. 2056-2063 ◽

Cited By ~ 12

Author(s):

Ling Liu ◽

Lei Fan ◽

Cheng Fang ◽

Zhi-Jian Zou ◽

Shu Yang ◽

...

Keyword(s):

Chronic Lymphocytic Leukemia ◽

Therapeutic Target ◽

Poor Prognosis ◽

Lymphocytic Leukemia ◽

Potential Therapeutic Target

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TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target

Cancer ◽

10.1002/cncr.28404 ◽

2013 ◽

Vol 120 (3) ◽

pp. 352-362 ◽

Cited By ~ 34

Author(s):

Sabrina Daniela da Silva ◽

Moulay A. Alaoui-Jamali ◽

Fernando Augusto Soares ◽

Dirce Maria Carraro ◽

Helena Paula Brentani ◽

...

Keyword(s):

Oral Cancer ◽

Molecular Marker ◽

Therapeutic Target ◽

Poor Prognosis ◽

Potential Therapeutic Target

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Aurora-A Identifies Early Recurrence and Poor Prognosis and Promises a Potential Therapeutic Target in Triple Negative Breast Cancer

PLoS ONE ◽

10.1371/journal.pone.0056919 ◽

2013 ◽

Vol 8 (2) ◽

pp. e56919 ◽

Cited By ~ 34

Author(s):

Jie Xu ◽

Xing Wu ◽

Wei-hua Zhou ◽

An-wen Liu ◽

Jian-bing Wu ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Therapeutic Target ◽

Poor Prognosis ◽

Triple Negative ◽

Early Recurrence ◽

Aurora A ◽

Potential Therapeutic Target

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Vitamin D/VDR in acute kidney injury: a potential therapeutic target

Current Medicinal Chemistry ◽

10.2174/0929867327666201118155625 ◽

2020 ◽

Vol 27 ◽

Author(s):

Siqing Jiang ◽

Lihua Huang ◽

Wei Zhang ◽

Hao Zhang

Keyword(s):

Vitamin D ◽

Acute Kidney Injury ◽

Therapeutic Target ◽

Poor Prognosis ◽

Therapeutic Potential ◽

Kidney Injury ◽

Potential Therapeutic Target ◽

Promising Therapeutic Target ◽

Incidence And Mortality

: Despite many strategies and parameters used in clinical practice, the incidence and mortality of acute kidney injury (AKI) are still high with poor prognosis. With the development of molecular biology, the role of vitamin D and vitamin D receptor (VDR) in AKI is drawing increasing attention. Accumulated researches have suggested that Vitamin D deficiency is a risk factor of both clinical and experimental AKI, and vitamin D/VDR could be a promising therapeutic target against AKI. However, more qualitative clinical researches are needed to provide stronger evidence for clinical application of vitamin D and VDR agonists in the future. Issues like the route and dosage of administration also await more attention. The present review aims to summarize the current works on the role of vitamin D/VDR in AKI and try to provide some new insight of its therapeutic potential.

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