scholarly journals First anti-oestrogen in the cyclopentadienyl rhenium tricarbonyl series. Synthesis and study of antiproliferative effects

2001 ◽  
pp. 383-384 ◽  
Author(s):  
Gérard Jaouen ◽  
Siden Top ◽  
Anne Vessières ◽  
Pascal Pigeon ◽  
Guy Leclercq ◽  
...  
Keyword(s):  
Antiproliferative Effects ◽  
Rhenium Tricarbonyl

Antiproliferative effects of Zanthoxilum rhoifolium

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AD Weber ◽  
CZ Stüker ◽  
G Zannon ◽  
V Ilha ◽  
II Dalcol ◽  
...  
Keyword(s):  
Antiproliferative Effects

Phytochemical and pharmacological (antiproliferative) effects of essential oil of Lavandula angustifolia Mill. Lamiaceae

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381 ◽  
Author(s):  
H Niksic ◽  
E Kovac-Besovic ◽  
M Sober ◽  
N Mulabegovic ◽  
M Kralj ◽  
...  
Keyword(s):  
Essential Oil ◽  
Lavandula Angustifolia ◽  
Antiproliferative Effects

Targeting Platelets Containing Electro-encapsulated lloprost to Balloon Injured Aorta in Rats

1995 ◽  
Vol 73 (03) ◽  
pp. 535-542 ◽  
Author(s):  
N Crawford ◽  
A Chajara ◽  
G Pfliegler ◽  
B EI Gamal ◽  
L Brewer ◽  
...  
Keyword(s):  
Time Course ◽  
Therapeutic Potential ◽  
Simple Procedure ◽  
Rat Aorta ◽  
Balloon Injury ◽  
Post Injury ◽  
Antiproliferative Effects ◽  
Platelet Deposition ◽  
Total Dna ◽  
Novel Drug

SummaryDrugs can be electro-encapsulated within platelets and targeted to damaged blood vessels by exploiting the platelet’s natural haemostatic properties to adhere to collagen and other vessel wall constituents revealed by injury. A rat aorta balloon angioplasty model has been used to study the effect on platelet deposition of giving iloprost loaded platelets i.v. during the balloon injury. After labelling the circulating platelets with 111-Indium before balloon injury, time course studies showed maximum platelet deposition on the injured aorta occurred at about 1 h post-injury and the deposition remained stable over the next 2-3 h. When iloprost-loaded platelets were given i.v. during injury and the circulating platelet pool labelled with 111-Indium 30 min later, platelet deposition, measured at 2 h postinjury, was substantially and significantly reduced compared with control platelet treatment. Some antiproliferative effects of iloprost-loaded platelets given i.v. during injury have also been observed. Whereas the incorporation of [3H]-thymidine into aorta intima-media DNA at 3 days post injury was 62-fold higher in balloon injured rats than in control sham operated rats, thymidine incorporation into intima/media of rats which had received iloprost loaded platelets during injury was reduced as compared with rats subjected only to the injury procedure. The reduction was only of near significance, however, but at 14 days after injury the total DNA content of the aorta intima/media of rats given iloprost loaded platelets during injury was significantly reduced. Although iloprost loaded platelets can clearly inhibit excessive platelet deposition, other encapsulated agents may have greater anti-proliferative effects. These studies have shown that drug loaded platelets can be targeted to injured arteries, where they may be retained as depots for local release. We believe this novel drug delivery protocol may have therapeutic potential in reducing the incidence of occlusion and restenosis after angioplasty and thrombolysis treatment. Electro-encapsulation of drugs into platelets is a simple procedure and, using autologous and fully biocompatible and biodegradable platelets as delivery vehicles, might overcome some of the immunological and toxicological problems which have been encountered with other delivery vectors such as liposomes, microbeads, synthetic microcapsules and antibodies.

Antiproliferative effects of lanreotide Autogel in patients with enteropancreatic neuroendocrine tumours: results of CLARINET, a large international phase 3 study

2014 ◽  
Author(s):  
Martyn Caplin ◽  
Philippe Ruszniewski ◽  
Marianne Pavel ◽  
Jaroslaw Cwikla ◽  
Alexandria Phan ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Phase 3 ◽  
Antiproliferative Effects ◽  
Lanreotide Autogel

Antiproliferative Effects of Sclerotial Polysaccharides from Polyporus rhinocerus Cooke (Aphyllophoromycetideae) on Different Kinds of Leukemic Cells

2008 ◽  
Vol 10 (3) ◽  
pp. 255-264 ◽  
Author(s):  
Connie K. M. Lai ◽  
Ka-Hing Wong ◽  
Peter Chi Keung Cheung
Keyword(s):  
Leukemic Cells ◽  
Antiproliferative Effects

Antiproliferative Effects of Palmitoylethanolamide on Human Cervical Cancer Cells

2019 ◽  
Author(s):  
Laura Bonfili ◽  
Valentina Cecarini ◽  
Anna Maria Eleuteri
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Antiproliferative Effects ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

Ellagic Acid: Cytodifferentiating and Antiproliferative Effects In Human Prostatic Cancer Cell Lines

2013 ◽  
Vol 19 (15) ◽  
pp. 2728-2736 ◽  
Author(s):  
Luca Vanella ◽  
Ignazio Barbagallo ◽  
Rosaria Acquaviva ◽  
Claudia Di Giacomo ◽  
Venera Cardile ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Ellagic Acid ◽  
Prostatic Cancer ◽  
Cancer Cell Lines ◽  
Antiproliferative Effects

Apoptotic Effects of N-(2-hydroxyphenyl)-2-propylpentanamide on U87-MG and U-2 OS Cells and Antiangiogenic Properties

2020 ◽  
Vol 20 ◽  
Author(s):  
Paola Castillo-Juárez ◽  
Sebastián C. Sanchez ◽  
Alma D. Chávez-Blanco ◽  
Humberto Mendoza-Figueroa ◽  
José Correa-Basurto
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Histone Deacetylases ◽  
Biochemical Mechanism ◽  
Antiproliferative Effects ◽  
Human Osteosarcoma ◽  
Antiproliferative Agent ◽  
Induced Apoptosis ◽  
Apoptotic Effects

Background and Objective: Histone deacetylases (HDACs) are important therapeutic targets for many types of human cancers. A derivative of valproic acid, N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), has antiproliferative properties on some cancer cell lines and inhibits the HDAC1 isoform. Materials and Methods: In this work, HO-AAVPA was tested as an antiproliferative agent in U87-MG (human glioblastoma) and U-2 OS cells (human osteosarcoma), which are types of cancer that are difficult to treat, and its antiangiogenic properties were explored. Results: HO-AAVPA had antiproliferative effects at 48 h with an IC50 = 0.655 mM in U87-MG cells and an IC50 = 0.453 mM in U-2 OS cells. Additionally, in the colony formation assay, HO-AAVPA decreased the number of colonies by approximately 99% in both cell lines and induced apoptosis by 31.3% in the U-2 OS cell line and by 78.2% in the U87-MG cell line. Additionally, HO-AAVPA reduced the number of vessels in chorioallantoid membranes (CAMs) by approximately 67.74% and IL-6 levels in both cell lines suggesting that the biochemical mechanism on cancer cell of HO-AAVPA is different compared to VPA. Conclusion: HO-AAVPA has antiproliferative effects on glioblastoma and osteosarcoma and antiangiogenic properties.

Antiproliferative Effects of Molecular Iodine in Cancers

2011 ◽  
Vol 5 (3) ◽  
pp. 168-176
Author(s):  
Pompilio Elio Torremante ◽  
Harald Rosner
Keyword(s):  
Molecular Iodine ◽  
Antiproliferative Effects
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