Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery

2005 ◽  
Vol 1 (3) ◽  
pp. 242 ◽  
Author(s):  
Younsoo Bae ◽  
Woo-Dong Jang ◽  
Nobuhiro Nishiyama ◽  
Shigeto Fukushima ◽  
Kazunori Kataoka
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Polymeric Micelles ◽  
Cell Targeting ◽  
Intracellular Drug Delivery ◽  
Cancer Cell Targeting

Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures

Nano Research ◽  
2015 ◽  
Vol 9 (1) ◽  
pp. 139-148 ◽  
Author(s):  
Yu Yang ◽  
Jingjing Liu ◽  
Xiaoqi Sun ◽  
Liangzhu Feng ◽  
Wenwen Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Near Infrared ◽  
Infrared Light ◽  
Cell Targeting ◽  
Near Infrared Light ◽  
Cancer Cell Targeting

Palmitoyl Ascorbate-Loaded Polymeric Micelles: Cancer Cell Targeting and Cytotoxicity

2010 ◽  
Vol 28 (2) ◽  
pp. 301-308 ◽  
Author(s):  
Rupa R. Sawant ◽  
Onkar Vaze ◽  
Gerard G. M. D’Souza ◽  
Karen Rockwell ◽  
Vladimir P. Torchilin
Keyword(s):  
Cancer Cell ◽  
Polymeric Micelles ◽  
Cell Targeting ◽  
Cancer Cell Targeting

β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery

2019 ◽  
Vol 206 ◽  
pp. 694-705 ◽  
Author(s):  
Manita Das ◽  
Archana Solanki ◽  
Apeksha Joshi ◽  
Ranjitsinh Devkar ◽  
Sriram Seshadri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Cell Targeting ◽  
Dual Responsive ◽  
Cancer Cell Targeting ◽  
Dual Drug

scholarly journals Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?

Oncotarget ◽  
2017 ◽  
Vol 8 (63) ◽  
pp. 107176-107187 ◽  
Author(s):  
Kylie Van Hoesen ◽  
Sonia Meynier ◽  
Pascale Ribaux ◽  
Patrick Petignat ◽  
Florence Delie ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Cancer Patients ◽  
Drug Delivery System ◽  
Cancer Cell ◽  
Delivery System ◽  
Cell Targeting ◽  
Promising Tool ◽  
Cancer Cell Targeting

scholarly journals Mesoporous silica nanoparticle-based intelligent drug delivery system for bienzyme-responsive tumour targeting and controlled release

2018 ◽  
Vol 5 (1) ◽  
pp. 170986 ◽  
Author(s):  
Yang Zhang ◽  
Juan Xu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Cell ◽  
Silica Nanoparticle ◽  
Cell Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Cancer Cell Targeting

This paper proposes a novel type of multifunctional envelope-type mesoporous silica nanoparticle (MSN) to achieve cancer cell targeting and drug-controlled release. In this system, MSNs were first modified by active targeting moiety hyaluronic acid (HA) for breast cancer cell targeting and hyaluronidases (Hyal)-induced intracellular drug release. Then gelatin, a proteinaceous biopolymer, was grafted onto the MSNs to form a capping layer via glutaraldehyde-mediated cross-linking. To shield against unspecific uptake of cells and prolong circulation time, the nanoparticles were further decorated with poly(ethylene glycol) polymers (PEG) to obtain MSN@HA-gelatin-PEG (MHGP). Doxorubicin (DOX), as a model drug, was loaded into PEMSN to assess the breast cancer cell targeting and drug release behaviours. In vitro study revealed that PEG chains protect the targeting ligand and shield against normal cells. After reaching the breast cancer cells, MMP-2 overpressed by cells hydrolyses gelatin layer to deshield PEG and switch on the function of HA. As a result, DOX-loaded MHGP was selectively trapped by cancer cells through HA receptor-mediated endocytosis and subsequently release DOX due to Hyal-catalysed degradation of HA. This system presents successful bienzyme-responsive targeting drug delivery in an optimal fashion and provides potential applications for targeted cancer therapy.

scholarly journals Multifunctional Nanoprobes for Cancer Cell Targeting, Imaging and Anticancer Drug Delivery

2015 ◽  
Vol 73 ◽  
pp. 216-220 ◽  
Author(s):  
Pavel Linkov ◽  
Marie Laronze-Cochard ◽  
Janos Sapi ◽  
Lev N. Sidorov ◽  
Igor Nabiev
Keyword(s):  
Drug Delivery ◽  
Cancer Cell ◽  
Anticancer Drug ◽  
Cell Targeting ◽  
Anticancer Drug Delivery ◽  
Cancer Cell Targeting
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