scholarly journals A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry: from chemical characterization to in vivo biodistribution

2018 ◽  
Vol 6 (7) ◽  
pp. 1754-1763 ◽  
Author(s):  
Francielle Pelegrin Garcia ◽  
Marlène Rippe ◽  
Mychelle V. P. Companhoni ◽  
Talitha Fernandes Stefanello ◽  
Benoit Louage ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Blood Circulation ◽  
Chemical Characterization ◽  
Circulation Time ◽  
In Vivo Biodistribution ◽  
Tumor Accumulation

Nanogels show long in vivo blood circulation time and high tumor accumulation.

scholarly journals In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles

2013 ◽  
Vol 172 (3) ◽  
pp. 699-706 ◽  
Author(s):  
Shanthi Ganesh ◽  
Arun K. Iyer ◽  
Florence Gattacceca ◽  
David V. Morrissey ◽  
Mansoor M. Amiji
Keyword(s):  
Hyaluronic Acid ◽  
In Vivo Biodistribution

scholarly journals Polysialic Acid Modified Liposomes for Improving Pharmacokinetics and Overcoming Accelerated Blood Clearance Phenomenon

Coatings ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 834
Author(s):  
Xi Han ◽  
Ting Zhang ◽  
Mengyang Liu ◽  
Yanzhi Song ◽  
Xinrong Liu ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Polysialic Acid ◽  
Repeated Administration ◽  
The Body ◽  
Circulation Time ◽  
Blood Clearance ◽  
In Vivo Evaluation ◽  
Accelerated Blood Clearance ◽  
Abc Phenomenon

Poly (ethylene glycol) (PEG) modified nanocarriers are being used widely in the drug delivery system (DDS). However, the “accelerated blood clearance (ABC) phenomenon” was induced upon repeated administration of PEG-modified liposomes, resulting in reduced blood circulation time, and increased accumulation in liver and spleen. To avoid the unexpected phenomenon, polysialic acid (PSA) was selected to modify liposomes. PSA is a natural, highly hydrophilic polysaccharide polymer for which no receptors exists in the body. It is non-immunogenic, biodegradable and endows the conjugated bioactive macromolecule and drugs with increased circulation time in vivo. In the present study, the in vivo evaluation showed that PSA modified liposomes (PSA-Lip) afford extended blood circulation in wistar rats and beagle dogs. Moreover, the ABC phenomenon did not occur and the IgM antibody was not induced after repeated injections of PSA-Lip. These results strongly suggest that PSA modification represents a promising strategy to afford good stealth of the liposomes without evoking the ABC phenomenon.

Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution

2009 ◽  
Vol 19 (24) ◽  
pp. 4102 ◽  
Author(s):  
Ki Young Choi ◽  
Kyung Hyun Min ◽  
Jin Hee Na ◽  
Kuiwon Choi ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Potential Drug ◽  
In Vivo Biodistribution ◽  
Self Assembled

scholarly journals Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

ACS Nano ◽  
2013 ◽  
Vol 7 (10) ◽  
pp. 8870-8880 ◽  
Author(s):  
Christopher E. Nelson ◽  
James R. Kintzing ◽  
Ann Hanna ◽  
Joshua M. Shannon ◽  
Mukesh K. Gupta ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Circulation Time ◽  
Endosome Escape

scholarly journals In Vivo Biodistribution, PET Imaging, and Tumor Accumulation of 86Y- and 111In-Antimindin/RG-1, Engineered Antibody Fragments in LNCaP Tumor-Bearing Nude Mice

2009 ◽  
Vol 50 (3) ◽  
pp. 435-443 ◽  
Author(s):  
D. W. Schneider ◽  
T. Heitner ◽  
B. Alicke ◽  
D. R. Light ◽  
K. McLean ◽  
...  
Keyword(s):  
Nude Mice ◽  
Pet Imaging ◽  
Antibody Fragments ◽  
Tumor Bearing ◽  
In Vivo Biodistribution ◽  
Tumor Accumulation

A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

2005 ◽  
Vol 288-289 ◽  
pp. 163-166 ◽  
Author(s):  
You Rong Duan ◽  
W.S. Liu ◽  
J. Liu ◽  
Z.R. Zhang
Keyword(s):  
Ethylene Glycol ◽  
Blood Circulation ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Systemic Blood ◽  
Model Drug ◽  
Poly Ethylene

The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

The effect of zwitterionic surface content on blood circulation time of nanocapsule

2020 ◽  
Vol 35 (3) ◽  
pp. 371-384
Author(s):  
Xing Han ◽  
Sidi Li ◽  
Xueping Li ◽  
Qi Zhan ◽  
Yueying Zhan ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Blood Circulation ◽  
Circulation Time ◽  
H Nmr ◽  
Surface Filling ◽  
Optimal Surface ◽  
Delivery Platform ◽  
Surface Content ◽  
The Relationship

Zwitterionic modification can prolong the blood circulation time of nanocarrier in vivo, but zwitterionic content will affect the functions of nanocarrier such as enzyme-responsive and intracellular or extracellular delivery. Therefore, it is necessary to explore the relationship between the zwitterionic content and circulation time of nanocarrier so as to figure out what content of zwitterion can enable the nanocarrier to obtain both the long blood circulation ability and other functions mentioned above. Herein, using nanocapsule as a research model, we investigated the nanocapsule modified with zwitterion of phosphorylcholine (PC) or carboxybetaine (CB) respectively, and through 1H-NMR quantification we determined the zwitterionic surface content, so as to study the effect of PC or CB surface content on blood circulation performance of nanocapsule. In vivo study showed that the nanocapsule possessed an optimal surface filling ratios range for blood circulation of 43–68% for PC and of 20–68% for CB, with the longest t1/2=37.35 h for PC-nanocapsule and t1/2=45.27 h for CB-nanocapsule. Furthermore, the protein adsorption and macrophage endocytosis experiments indicated that when the surface filling ratio reached 43% for PC-nanocapsule and 20% for CB-nanocapsule, it could effectively reduce the protein adsorption and weaken macrophage endocytosis, thus explaining the phenomenon of long circulation time of nanocapsules from the point of protein adsorption and interaction with immune cells. This study proposes a new direction for designing long-circulating nanocarrier, and provides basis for constructing enzyme-responsive and intracellular or extracellular delivery platform.

Phosphorylcholine micelles decorated by hyaluronic acid for enhancing antitumor efficiency

2017 ◽  
Vol 8 (16) ◽  
pp. 2472-2483 ◽  
Author(s):  
Shuai Li ◽  
Yuanyuan Cai ◽  
Jun Cao ◽  
Mengtan Cai ◽  
Yuanwei Chen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Blood Circulation ◽  
Electrostatic Attraction ◽  
Circulation Time

DOX-loaded PCL-PDEAMPC micelles coated with HA by electrostatic attraction for enhancing antitumor efficiency and prolonging blood circulation time.

scholarly journals Extended in vivo blood circulation time of fluorinated liposomes

FEBS Letters ◽  
1993 ◽  
Vol 336 (3) ◽  
pp. 481-484 ◽  
Author(s):  
Catherine Santaella ◽  
Frédéric Frézard ◽  
Pierre Vierling ◽  
Jean G. Riess
Keyword(s):  
Blood Circulation ◽  
Circulation Time
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