A high-performance and simple method for rapid and simultaneous determination of dihydroxybenzene isomers

The Analyst ◽  
2012 ◽  
Vol 137 (4) ◽  
pp. 944-952 ◽  
Author(s):  
Yanli Quan ◽  
Zhonghua Xue ◽  
Haicai Shi ◽  
Xibing Zhou ◽  
Jie Du ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
High Performance ◽  
Simple Method ◽  
Dihydroxybenzene Isomers

High-performance electrochemical sensing platform based on sodium alginate-derived 3D hierarchically porous carbon for simultaneous determination of dihydroxybenzene isomers

2021 ◽  
Author(s):  
Liang Wei ◽  
Xinlong Huang ◽  
Xianqian Zhang ◽  
Xiande Yang ◽  
Jing Yang ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Simultaneous Determination ◽  
Porous Carbon ◽  
High Performance ◽  
Three Dimensional ◽  
Electrochemical Sensing ◽  
Dihydroxybenzene Isomers ◽  
Hierarchically Porous ◽  
Sensing Platform

A selective and sensitive electrochemical sensor based on three-dimensional hierarchically porous carbon was developed for simultaneous determination of dihydroxybenzene isomers.

scholarly journals Column High-Performance Liquid Chromatographic Method for the Simultaneous Determination of Rosiglitazone and Metformin in a Pharmaceutical Preparation

2009 ◽  
Vol 92 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Azzam R Ali ◽  
Ibrahim I Duraidi ◽  
Munib M Saket ◽  
Eyad S M Abu-Nameh
Keyword(s):  
Simultaneous Determination ◽  
High Performance ◽  
Pharmaceutical Preparation ◽  
High Performance Liquid Chromatographic ◽  
Metformin Hydrochloride ◽  
Dihydrogen Phosphate ◽  
Simple Method ◽  
Combination Tablet ◽  
Tablet Dosage

Abstract An efficient, sensitive, and simple method was developed for the simultaneous determination of rosiglitazone and metformin hydrochloride in a combination tablet dosage form by column high-performance liquid chromatography. The mobile phase used was ammonium dihydrogen phosphate adjusted to pH 5.25 with sodium hydroxide. The limits of detection and quantitation were in the range of 0.51.6 g/mL, respectively, for metformin hydrochloride, and 0.002010.0067 g/mL, respectively, for rosiglitazone. The linearity was studied in the concentration range of 0.120.31 g/mL for rosiglitazone and 30.676.7 g/mL for metformin hydrochloride. The recovered amounts of metformin hydrochloride and rosiglitazone were 100103.8 and 101103.7, respectively.

Simultaneous determination of several veterinary pharmaceuticals in effluents from urban, livestock and slaughterhouse wastewater treatment plants using a simple chromatographic method

2012 ◽  
Vol 66 (3) ◽  
pp. 603-611 ◽  
Author(s):  
Simone Cavenati ◽  
Pedro N. Carvalho ◽  
C. Marisa R. Almeida ◽  
M. Clara P. Basto ◽  
M. Teresa S. D. Vasconcelos
Keyword(s):  
Wastewater Treatment ◽  
Simultaneous Determination ◽  
High Performance ◽  
Wastewater Treatment Plants ◽  
Solid Phase ◽  
Array Detector ◽  
Simple Method ◽  
Urban Network ◽  
Veterinary Pharmaceuticals

Minocycline, oxytetracycline, tetracycline, enrofloxacin and ceftiofur, commonly used veterinary pharmaceuticals, were searched in four urban, two livestock and two slaughterhouse effluents from wastewater treatment plants (WWTPs) in the north of Portugal. A simple method that includes solid-phase extraction followed with analysis by high-performance liquid chromatography with diode array detector was established and applied to the simultaneous determination of the five pharmaceuticals in WWTP effluents. This method, which is expeditious, inexpensive and available in most laboratories, showed to be useful for screening for problematic levels of drugs in WWTP effluents. It is known that several livestock and slaughterhouse effluents (pre-treated or treated) are discharged to the urban network before discharge into the environment. The presence of these drugs in such effluents can constitute a significant environmental problem that should be addressed, by the monitoring of these drugs and by implementation of methodologies that contribute to their decrease/elimination from wastewaters. Minocycline (≤6 μg L−1), oxytetracycline (≤7 μg L−1), tetracycline (≤6 μg L−1) and enrofloxacin (<2 μg L−1) could be detected and/or quantified in three urban effluents. Detectable levels of enrofloxacin (<2 μg L−1) and quantifiable levels of tetracycline (≤15 μg L−1) were found in the slaughterhouse effluents.

scholarly journals Simultaneous Determination of Caffeine and Chlorogenic Acids in Green Coffee by UV/Vis Spectroscopy

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
G. Navarra ◽  
M. Moschetti ◽  
V. Guarrasi ◽  
M. R. Mangione ◽  
V. Militello ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
High Performance ◽  
Chemical Separation ◽  
Ethanol Solution ◽  
Green Coffee ◽  
Chlorogenic Acids ◽  
Absorption Bands ◽  
Simple Method ◽  
Vis Spectroscopy

A simple method for the simultaneous determination of caffeine and chlorogenic acids content in green coffee was reported. The method was based on the use of UV/Vis absorption. It is relevant that the quantification of both caffeine and chlorogenic acids was performed without their preliminary chemical separation despite their spectral overlap in the range 250–350 nm. Green coffee was extracted with 70% ethanol aqueous solution; then the solution was analyzed by spectroscopy. Quantitative determination was obtained analytically through deconvolution of the absorption spectrum and by applying the Lambert-Beer law. The bands used for the deconvolution were the absorption bands of both caffeine and chlorogenic acids standards. The molar extinction coefficients for caffeine and chlorogenic acid in ethanol solution at 70% were calculated by using the chemical standards; the estimated values wereε(272 nm)=12159±97 M−1 cm−1for caffeine andε(330 nm)=27025±190 M−1 cm−1for chlorogenic acids molecules, respectively. The estimate of concentration values was in agreement with the one obtained by High Performance Liquid Chromatography quantification. The method is fast and simple and allows us to realize routine controls during the coffee production. In addition, it could be applied on roasted coffee and espresso coffee.

Analysis of Tetracyclines (TCs) Residues in Honey with HPLC - UV

2010 ◽  
Vol 159 ◽  
pp. 89-94
Author(s):  
Hai Ying Zhang ◽  
Dong Hui Chen ◽  
Yi Zheng ◽  
Hong Tao Hu
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Perchloric Acid ◽  
Mass Concentration ◽  
High Performance ◽  
Simple Method ◽  
Coefficient Variation ◽  
Precision And Accuracy

Simultaneous determination of oxytetracycline (OTC), tetracycline (TC), chlortetracycline (CTC), and doxycycline (DC) residues in honey was performed using a high-performance liquid chromatography with ultraviolet spectrophotometer ant this method was validated by analysis of precision and accuracy. Honey was digested using perchloric acid of 2% mass concentration. Matrix matched calibration curves showed a linearity exceeding 0.99. The recovery ratios lay between 75.9% and 92.5% and the coefficient variation was lower than 16.6%. Limits of detection and quantitation were below 0.03µg mL-1 and 0.09µg mL-1, respectively, for OTC and TC, and below 0.07µg mL-1 and 0.20µg mL-1, respectively, for CTC and DC. The experiments demonstrated that it is a simple method suitable for detection of residual TCs in honey.

scholarly journals Simultaneous Determination of Eight β-Lactam Antibiotics, Amoxicillin, Cefazolin, Cefepime, Cefotaxime, Ceftazidime, Cloxacillin, Oxacillin, and Piperacillin, in Human Plasma by Using Ultra-High-Performance Liquid Chromatography with Ultraviolet Detection

2016 ◽  
Vol 60 (8) ◽  
pp. 4734-4742 ◽  
Author(s):  
Tiphaine Legrand ◽  
Dominique Vodovar ◽  
Nicolas Tournier ◽  
Nihel Khoudour ◽  
Anne Hulin
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
High Performance ◽  
Internal Standard ◽  
Therapeutic Drug ◽  
Simple Method ◽  
Validation Parameters

ABSTRACTA simple and rapid ultra-high-performance liquid chromatography (UHPLC) method using UV detection was developed for the simultaneous determination of eight β-lactam antibiotics in human plasma, including four penicillins, amoxicillin (AMX), cloxacillin (CLX), oxacillin (OXA), and piperacillin (PIP), and four cephalosporins, cefazolin (CFZ), cefepime (FEP), cefotaxime (CTX), and ceftazidime (CAZ). One hundred-microliter samples were spiked with thiopental as an internal standard, and proteins were precipitated by acetonitrile containing 0.1% formic acid. Separation was achieved on a pentafluorophenyl (PFP) column with a mobile phase composed of phosphoric acid (10 mM) and acetonitrile in gradient elution mode at a flow rate of 500 μl/min. Detection was performed at 230 nm for AMX, CLX, OXA, and PIP and 260 nm for CFZ, FEP, CTX, and CAZ. The total analysis time did not exceed 13 min. The method was found to be linear at concentrations ranging from 2 to 100 mg/liter for each compound, and all validation parameters fulfilled international requirements. Between- and within-run accuracy errors ranged from −5.2% to 11.4%, and precision was lower than 14.2%. This simple method requires small-volume samples and can easily be implemented in most clinical laboratories to promote the therapeutic drug monitoring of β-lactam antibiotics. The simultaneous determination of several antibiotics considerably reduces the time to results for clinicians, which may improve treatment efficiency, especially in critically ill patients.

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