ANTHROPONYMS IN GENRE DIVERSITY IN THE ADVERTISING TEXTS OF VETERINARY PHARMACEUTICALS IN THE BEGINNING OF THE 20th CENTURY

Introduction. The article discusses the features of proper names in advertising texts of veterinary pharmaceuticals. Attention is paid to the description of structural and semantic features of anthroponyms. We investigate proper names as the part of the structure of advertising texts of veterinary pharmaceuticals. The purpose of the article is the analysis of anthroponyms in advertising texts of veterinary pharmaceuticals. The object of the study is proper names in advertising texts of veterinary pharmaceuticals. The subject of the study is anthroponyms in advertising texts in the beginning of the 20th century. Materials and methods. The purpose determines the choice of methods in our study: general scientific methods of systematization, analysis and synthesis, quantitative analysis were used. The descriptive method of advertising texts is used in the work. Among the special linguistic methods, structural one was used, which helped in determining the features of the structure of anthroponyms. Anthroponyms for our research have been taken from the newspaper “Public Veterinary Bulletin” for the period of 1904-1906 years. Results. As a result of the study, structural and semantic features of anthroponyms were established. Сonclusions. Anthroponyms learned in advertising texts of veterinary pharmaceuticals in the beginning of the 20th century had been used almost in all analyzed texts. The practical value of the work lies in the fact that the analysis of anthroponyms in advertising texts opens up prospects for further researches, which may be connected with the identification of the specific characteristics of proper names in the advertising texts of veterinary pharmaceuticals in different languages. Summing up, a thorough analysis of the advertising texts of veterinary pharmaceuticals helped to establish the structure and functioning peculiarities of anthroponyms.

Fourth and final issue of GaBI Journal’s 10th volume

This issue of the GaBI Journal contains only a limited number of articles, but these include two scientifi c very data-rich articles and an interesting and important expose on the use and misuse of products to treat COVID-19 patients. All three articles have potentially major implications for the global struggle to deal with the current COVID-19 pandemic; either with respect to the proper use of biosimilar products to safely reduce COVID-19 related and non-related pharmaceutical expenditures, as well as to the effects of the pandemic on the criminal use and abuse of human and veterinary pharmaceuticals and other products, e.g. disinfectants.

Ecological Risk Assessment of Amoxicillin, Enrofloxacin, and Neomycin: Are Their Current Levels in the Freshwater Environment Safe?

Veterinary pharmaceuticals may cause unexpected adverse effects on non-target aquatic species. While these pharmaceuticals were previously identified as priority compounds in ambient water, their ecological risks are relatively unknown. In this study, a series of chronic toxicity tests were conducted for these pharmaceuticals using algae, two cladocerans, and a fish. After a 21-d exposure to amoxicillin, enrofloxacin, and neomycin, no observed effect concentration (NOEC) for the reproduction of Daphnia magna was detected at 27.2, 3.3, and 0.15 mg/L, respectively. For the survival of juvenile Oryzias latipes following the 40-d exposure, NOEC was found at 21.8, 3.2, and 0.87 mg/L, respectively. Based on the results of the chronic toxicity tests and those reported in the literature, predicted no-effect concentrations (PNECs) were determined at 0.078, 4.9, and 3.0 µg/L for amoxicillin, enrofloxacin, and neomycin, respectively. Their hazard quotients (HQs) were less than 1 at their average levels of occurrence in ambient freshwater. However, HQs based on the maximum detected levels of amoxicillin and enrofloxacin were determined at 21.2 and 6.1, respectively, suggesting potential ecological risks. As the potential ecological risks of these veterinary pharmaceuticals at heavily contaminated sites cannot be ignored, hotspot delineation and its management are required.

Spatio-Temporal Distribution and Influencing Factors of Human and Veterinary Pharmaceuticals in the Tributary Surface Waters of the Han River Watershed, South Korea

Human and veterinary pharmaceuticals are being increasingly used for disease treatment; hence, their distribution and factors influencing them in the aquatic environment need to be investigated. This study observed the effect of human and animal populations, usage, purchasing criteria (prescription vs. non-prescription), and land use to identify the spatio-temporal distribution of eight pharmaceuticals at twenty-four sites of the tributaries of the Han River watershed. In rural areas, the mean concentration (detection frequency) of non-prescription pharmaceuticals (NPPs) was higher (lower) compared to that of prescription pharmaceuticals (PPs); in urban areas, a reverse trend was observed. Pharmaceutical concentrations in urban and rural areas were mainly affected by wastewater treatment plants (WWTPs) and non-point sources, respectively; concentrations were higher downstream (4.9 times) than upstream of the WWTPs. The concentration distribution (according to the target) was as follows: human–veterinary > human > veterinary. Correlation between total concentration and total usage of the pharmaceuticals was high, except for NPPs. Most livestock and land use (except cropland) were significantly positively correlated with pharmaceutical concentrations. Concentrations were mainly higher (1.5 times) during cold seasons than during warm seasons. The results of this study can assist policymakers in managing pharmaceutical pollutants while prioritizing emerging pollutants.

How to decrease pharmaceuticals in the environment? A review

The global problem of the presence of human and veterinary pharmaceuticals in the environment is under investigation. Despite the increase in the knowledge of its sources, fates and impacts, the assessment of risks and the derived prevention actions are limited to single cases. The predicted increasing trend in the usage of pharmaceuticals forces the various parties involved to think about comprehensive mitigation actions. There are many areas of daily human life and industrial operations where such actions should take place. Thereby, in the presented review, such actions were summarized and divided into the following groups: A. design, synthesis and production of pharmaceuticals, B. prescription, sales and waste handling, C. control of the sources with advanced technologies. As the total amount of proposed actions was found to be quite high, a ranking according to the term of effects was proposed using the pyramid of needs. The advantages of actions taken in the first steps of the pharmaceutical life cycle (acting on the upstream) over end-of-pipe actions and the application of advanced technologies (the downstream option) were discussed, with reference to expert opinions.

Use of Veterinary Pharmaceuticals and Application via Manure Slurries to Soil in the Netherlands

<p>Veterinary Pharmaceuticals (VPs) are used world-wide to cure or prevent illness of animals, and increasingly investigated in view of emissions into the environment. It is known that environmental routes of VPs are complex while transport rates and persistence are not yet well established. Our investigation focuses on the route till application of VPs in (liquid) manure to soil. To characterize this for the Netherlands, we investigated national usage of 4 livestock sectors (dairy cow, veal calf, sow and fattening pig), as well as animal excretion rates prior and degradation during slurry manure storage. This has been done for 12 antibiotics, 4 antiparasitic drugs and one hormone. An inventory of data bases and taking into account data reliability, revealed for almost all substances a reduction of quantities administrated to the animals during the period 2015-2018. Literature review on excretion rates identified that there is still insufficient information, despite that those rates directly influence the VP portions in the environment. Our developed storage model showed that VPs concentrations during a period of 6 months could reduce by a factor as large as 60 and that the fractions present in that manure are highly dependent on animal type, quantity of produced manure and substance degradation rates. At the same time, our predicted after-storage concentrations were found to be comparable with the reported measurements available for some parts of the Netherlands. Considering that similar manure types are applied on arable lands and grasslands in considerable quantities in many other countries, our approach and results may represent a good foundation for further research on the environmental fate of VPs.</p>

Monitoring of veterinary pharmaceuticals in the Bienne river (Jura Mountain, France)

<p>The Bienne river (Jura Mountain, France) drains a basin of medium altitude mountains characterized by extensive cattle breeding (mostly dairy cows). A monitoring of the contamination by veterinary pharmaceuticals was performed using passive sampling devices - POCIS (Polar Organic Chemical Integrative Samplers), between September 2019 and January 2020. Four hydrological conditions were analysed: a sever low-flow periods, two flood events and a winter situation close to the mean interannual flow. Each time, POCIS were exposed over 2 weeks at 2 stations located in the upper and downstream reaches of the river. 19 pharmaceuticals were selected from information given by local veterinarians and analysed by LC MS-MS: endo and ectoparasites treatments; antibiotics and non-steroidal anti-inflammatory drugs. The monitoring shows that most of these chemicals (12 substances) are quantified in all POCIS samples and the others show relatively high occurrences, between 25 and 88%. Average concentrations in water (calculated with the sampling rate i.e. considering the time of exposition of POCIS samplers in the river) are remarkably close between the 2 monitoring stations. Concentrations are high all over the studied period and reach a maximum during flood events. Thus, hazardous effects are expected on freshwater organisms, especially for macrocyclic lactones and pyrethroids and organophosphates pesticides. The antibiotics concentrations ranges can also disturb microbial communities existing in the river. Such results highlight an important impregnation by these pharmaceuticals at the catchment scale, involving diffuse sources as grasslands receiving contaminated cow dungs and manures. Veterinary compounds are strongly remobilized during rain episodes by run off and infiltration in soils. In the hydrogeological context of the Bienne basin, karstic flows emphasize the connectivity between grasslands and the river. Therefore, an important part of the contaminated leaching waters can rapidly reach the river via the soil drains and surface / subsurface flows. Rather than another part goes through less porosity pathways and delivers pollutants over a longer period. Wastewater discharges and sludges from rural and urban treatment plants can also contribute to this pollution for pharmaceuticals also used in human medications.</p>