Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform

2015 ◽  
Vol 51 (13) ◽  
pp. 2555-2558 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Lu An ◽  
Wei-Wei Tang ◽  
Shi-Ping Yang ◽  
Jin-Gang Liu
Keyword(s):  
Nitric Oxide ◽  
Singlet Oxygen ◽  
Intracellular Delivery ◽  
Ruthenium Nitrosyl

A multifunctional nitric oxide (NO) delivery nanoplatform that combines functionalities of target directing, fluorescence tracking, and photo-controlled target attacking was developed.

scholarly journals Cold Atmospheric Pressure Plasma-Activated Medium Induces Selective Cell Death in Human Hepatocellular Carcinoma Cells Independently of Singlet Oxygen, Hydrogen Peroxide, Nitric Oxide and Nitrite/Nitrate

2021 ◽  
Vol 22 (11) ◽  
pp. 5548
Author(s):  
Yan Li ◽  
Tianyu Tang ◽  
Haejune Lee ◽  
Kiwon Song
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Singlet Oxygen ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Proliferative Effect ◽  
Huh7 Cells ◽  
Anti Cancer ◽  
Cold Atmospheric Pressure Plasma ◽  
Nitrite Nitrate

Cold atmospheric pressure plasma (CAP) and plasma-activated medium (PAM) induce cell death in diverse cancer cells and may function as powerful anti-cancer agents. The main components responsible for the selective anti-cancer effects of CAP and PAM remain elusive. CAP or PAM induces selective cell death in hepatocellular carcinoma cell lines Hep3B and Huh7 containing populations with cancer stem cell markers. Here, we investigated the major component(s) of CAP and PAM for mediating the selective anti-proliferative effect on Hep3B and Huh7 cells. The anti-proliferative effect of CAP was mediated through the medium; however, the reactive oxygen species scavenger N-acetyl cysteine did not suppress PAM-induced cell death. Neither high concentrations of nitrite or nitrite/nitrate nor a low concentration of H2O2 present in the PAM containing sodium pyruvate affected the viability of Hep3B and Huh7 cells. Inhibitors of singlet oxygen, superoxide anions, and nitric oxide retained the capacity of PAM to induce anti-cancer effects. The anti-cancer effect was largely blocked in the PAM prepared by placing an aluminum metal mesh, but not a dielectric PVC mesh, between the plasma source and the medium. Hence, singlet oxygen, hydrogen peroxide, nitric oxide, and nitrite/nitrate are not the main factors responsible for PAM-mediated selective death in Hep3B and Huh7 cells. Other factors, such as charged particles including various ions in CAP and PAM, may induce selective anti-cancer effects in certain cancer cells.

Dual-Function Multilayers for the Photodelivery of Nitric Oxide and Singlet Oxygen

ChemPhysChem ◽  
2009 ◽  
Vol 10 (17) ◽  
pp. 3077-3082 ◽  
Author(s):  
Gabriele Giancane ◽  
Ludovico Valli ◽  
Salvatore Sortino
Keyword(s):  
Nitric Oxide ◽  
Singlet Oxygen ◽  
Dual Function

Functional gold nanoparticles for the storage and controlled release of nitric oxide: applications in biofilm dispersal and intracellular delivery

2014 ◽  
Vol 2 (31) ◽  
pp. 5003-5011 ◽  
Author(s):  
Hien T. T. Duong ◽  
Nik Nik M. Adnan ◽  
Nicolas Barraud ◽  
Johan S. Basuki ◽  
Samuel K. Kutty ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gold Nanoparticles ◽  
Controlled Release ◽  
Intracellular Delivery ◽  
Functional Polymers ◽  
No Donor ◽  
Biofilm Dispersal

Gold nanoparticles (size 10 nm) were designed to store and release nitric oxide (NO), by functionalizing their surfaces with functional polymers modified with NO-donor molecules.

Antibacterial nitric oxide- and singlet oxygen-releasing polystyrene nanoparticles responsive to light and temperature triggers

Nanoscale ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 2639-2648 ◽  
Author(s):  
Jiří Dolanský ◽  
Petr Henke ◽  
Zuzana Malá ◽  
Ludmila Žárská ◽  
Pavel Kubát ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antibacterial Activity ◽  
Singlet Oxygen ◽  
Temperature Control ◽  
Polystyrene Nanoparticles

Polystyrene nanoparticles release nitric oxide and singlet oxygen under light and temperature control, and exhibit strong antibacterial activity.

Melatonin: Lowering the High Price of Free Radicals

Physiology ◽  
2000 ◽  
Vol 15 (5) ◽  
pp. 246-250 ◽  
Author(s):  
Russel J. Reiter
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Free Radicals ◽  
Singlet Oxygen ◽  
High Price ◽  
Antioxidative Defense ◽  
Defense System ◽  
Toxic Species ◽  
Peroxynitrite Anion ◽  
Molecular Toxicity

The endogenous antioxidative defense system reduces molecular toxicity of oxygen and nitrogen-based reactive species. Melatonin is an efficient direct and indirect antioxidant. It detoxifies the highly reactive hydroxyl radical and neutralizes other toxic species, including singlet oxygen, hydrogen peroxide, nitric oxide, and peroxynitrite anion, and stimulates several antioxidative enzymes.

Nitric oxide and singlet oxygen photo-generation by light irradiation in the phototherapeutic window of a nitrosyl ruthenium conjugated with a phthalocyanine rare earth complex

Polyhedron ◽  
2009 ◽  
Vol 28 (13) ◽  
pp. 2766-2770 ◽  
Author(s):  
Simone Aparecida Cicillini ◽  
Ana Carolina Lemos Prazias ◽  
Antonio Claudio Tedesco ◽  
Osvaldo Antonio Serra ◽  
Roberto Santana da Silva
Keyword(s):  
Nitric Oxide ◽  
Rare Earth ◽  
Singlet Oxygen ◽  
Light Irradiation ◽  
Rare Earth Complex
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