scholarly journals The potential of microfluidic lung epithelial wounding: towardsin vivo-like alveolar microinjuries

2014 ◽  
Vol 6 (12) ◽  
pp. 1132-1140 ◽  
Author(s):  
M. Felder ◽  
A. O. Stucki ◽  
J. D. Stucki ◽  
T. Geiser ◽  
O. T. Guenat
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Flow Focusing ◽  
Esophageal Reflux ◽  
Acidic Solutions ◽  
Model Based ◽  
Lung Epithelial

A lung epithelial wounding model based on flow focusing of acidic solutions similar to gastric esophageal reflux provides evidence of microaspiration-induced alveolar microinjuries, a typical hallmark of idiopathic pulmonary fibrosis.

scholarly journals Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Alison E. John ◽  
Rebecca H. Graves ◽  
K. Tao Pun ◽  
Giovanni Vitulli ◽  
Ellen J. Forty ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Small Molecule ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Lung Epithelial Cells ◽  
Tgfβ Signaling ◽  
Lung Epithelial ◽  
Translational Pharmacology ◽  
Αvβ6 Integrin

Abstract The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule αvβ6 RGD-mimetic, GSK3008348, and profiled it in a range of disease relevant pre-clinical systems. To understand the relationship between target engagement and inhibition of fibrosis, we measured pharmacodynamic and disease-related end points. Here, we report, GSK3008348 binds to αvβ6 with high affinity in human IPF lung and reduces downstream pro-fibrotic TGFβ signaling to normal levels. In human lung epithelial cells, GSK3008348 induces rapid internalization and lysosomal degradation of the αvβ6 integrin. In the murine bleomycin-induced lung fibrosis model, GSK3008348 engages αvβ6, induces prolonged inhibition of TGFβ signaling and reduces lung collagen deposition and serum C3M, a marker of IPF disease progression. These studies highlight the potential of inhaled GSK3008348 as an anti-fibrotic therapy.

The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis

2019 ◽  
Vol 61 (6) ◽  
pp. 713-726 ◽  
Author(s):  
Henrik M. Ulke ◽  
Kathrin Mutze ◽  
Mareike Lehmann ◽  
Darcy E. Wagner ◽  
Katharina Heinzelmann ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Epithelial Cell ◽  
Cell Phenotype ◽  
Lung Epithelial

scholarly journals Model-based Meta-Analysis on the Efficacy of Pharmacological Treatments for Idiopathic Pulmonary Fibrosis

2017 ◽  
Vol 6 (10) ◽  
pp. 695-704 ◽  
Author(s):  
Phyllis Chan ◽  
Leon Bax ◽  
Chunlin Chen ◽  
Nancy Zhang ◽  
Shu-Pang Huang ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Meta Analysis ◽  
Pharmacological Treatments ◽  
Model Based

scholarly journals Characteristics of gastro-esophageal reflux in patients with idiopathic pulmonary fibrosis

2015 ◽  
Vol 64 (2) ◽  
pp. 505-511 ◽  
Author(s):  
Sameh Embarak ◽  
Salama E. Farag ◽  
Ahmed S. Bihery ◽  
Ayman F. Ahmed ◽  
Hala Y. Yousef
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Esophageal Reflux
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