The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis

2019 ◽  
Vol 61 (6) ◽  
pp. 713-726 ◽  
Author(s):  
Henrik M. Ulke ◽  
Kathrin Mutze ◽  
Mareike Lehmann ◽  
Darcy E. Wagner ◽  
Katharina Heinzelmann ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Epithelial Cell ◽  
Cell Phenotype ◽  
Lung Epithelial

scholarly journals Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis

2010 ◽  
Vol 37 (1) ◽  
pp. 79-87 ◽  
Author(s):  
E.-M. Pfaff ◽  
S. Becker ◽  
A. Gunther ◽  
M. Konigshoff
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Epithelial Cell ◽  
Epithelial Cell Proliferation ◽  
Lung Epithelial

Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis

Pneumologie ◽  
2010 ◽  
Vol 64 (01) ◽  
Author(s):  
EM Pfaff ◽  
S Becker ◽  
A Guenther ◽  
O Eickelberg ◽  
M Königshoff
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Epithelial Cell ◽  
Epithelial Cell Proliferation ◽  
Lung Epithelial

scholarly journals The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes

2020 ◽  
Vol 21 (16) ◽  
pp. 5595
Author(s):  
Paul Cheresh ◽  
Seok-Jo Kim ◽  
Long Shuang Huang ◽  
Satoshi Watanabe ◽  
Nikita Joshi ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Pulmonary Fibrosis ◽  
Lung Fibrosis ◽  
Sphingosine Kinase ◽  
Lung Epithelial Cell ◽  
Lung Fibroblasts ◽  
Sphingosine Kinase 1 ◽  
Mtdna Damage ◽  
Lung Epithelial ◽  
Monocyte Recruitment

Idiopathic pulmonary fibrosis (IPF) is a chronic disease for which novel approaches are urgently required. We reported increased sphingosine kinase 1 (SPHK1) in IPF lungs and that SPHK1 inhibition using genetic and pharmacologic approaches reduces murine bleomycin-induced pulmonary fibrosis. We determined whether PF543, a specific SPHK1 inhibitor post bleomycin or asbestos challenge mitigates lung fibrosis by reducing mitochondrial (mt) DNA damage and pro-fibrotic monocyte recruitment—both are implicated in the pathobiology of pulmonary fibrosis. Bleomycin (1.5 U/kg), crocidolite asbestos (100 µg/50 µL) or controls was intratracheally instilled in Wild-Type (C57Bl6) mice. PF543 (1 mg/kg) or vehicle was intraperitoneally injected once every two days from day 7−21 following bleomycin and day 14−21 or day 30−60 following asbestos. PF543 reduced bleomycin- and asbestos-induced pulmonary fibrosis at both time points as well as lung expression of profibrotic markers, lung mtDNA damage, and fibrogenic monocyte recruitment. In contrast to human lung fibroblasts, asbestos augmented lung epithelial cell (MLE) mtDNA damage and PF543 was protective. Post-exposure PF543 mitigates pulmonary fibrosis in part by reducing lung epithelial cell mtDNA damage and monocyte recruitment. We reason that SPHK1 signaling may be an innovative therapeutic target for managing patients with IPF and other forms of lung fibrosis.

scholarly journals cis-acting elements that confer lung epithelial cell expression of the CC10 gene.

1992 ◽  
Vol 267 (21) ◽  
pp. 14703-14712
Author(s):  
B.R. Stripp ◽  
P.L. Sawaya ◽  
D.S. Luse ◽  
K.A. Wikenheiser ◽  
S.E. Wert ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Lung Epithelial Cell ◽  
Cis Acting ◽  
Lung Epithelial ◽  
Cell Expression

scholarly journals Impact of copper oxide particle dissolution on lung epithelial cell toxicity: response characterization using global transcriptional analysis

2021 ◽  
pp. 1-20
Author(s):  
Andrey Boyadzhiev ◽  
Mary-Luyza Avramescu ◽  
Dongmei Wu ◽  
Andrew Williams ◽  
Pat Rasmussen ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Copper Oxide ◽  
Oxide Particle ◽  
Lung Epithelial Cell ◽  
Transcriptional Analysis ◽  
Cell Toxicity ◽  
Particle Dissolution ◽  
Lung Epithelial ◽  
Toxicity Response
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