Synthesis and biological evaluation of a new class of quinazolinoneazoles as potential antimicrobial agents and their interactions with calf thymus DNA and human serum albumin

MedChemComm ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 222-229 ◽  
Author(s):  
Li-Ping Peng ◽  
Sangaraiah Nagarajan ◽  
Syed Rasheed ◽  
Cheng-He Zhou

A series of quinazolinone azoles were synthesized and screened for their antimicrobial activities, and further studies of their binding behaviors with calf thymus DNA and human serum albumin were investigated.

2020 ◽  
Vol 29 (11) ◽  
pp. 1956-1975
Author(s):  
Alberto Martínez ◽  
Mai Zahran ◽  
Miguel Gomez ◽  
Johnny Guevara ◽  
Rosemary Pichardo-Bueno ◽  
...  

MedChemComm ◽  
2013 ◽  
Vol 4 (5) ◽  
pp. 839 ◽  
Author(s):  
Shao-Lin Zhang ◽  
Juan-Juan Chang ◽  
Guri L. V. Damu ◽  
Rong-Xia Geng ◽  
Cheng-He Zhou

2019 ◽  
Vol 48 (34) ◽  
pp. 12933-12942 ◽  
Author(s):  
Dhananjay Das ◽  
Atrayee Banaspati ◽  
Namisha Das ◽  
Bidisha Bora ◽  
Md Kausar Raza ◽  
...  

Co(ii) complexes having an anthracene-based curcuminoid ligand display moderate binding propensity towards calf thymus DNA and human serum albumin and remarkable photo-cytotoxicity in HeLa, MCF-7 and MDA-MB-231 cells on excitation with visible light.


2018 ◽  
Vol 37 (11) ◽  
pp. 2789-2800 ◽  
Author(s):  
Hamid Tanzadehpanah ◽  
Hanie Mahaki ◽  
Pouria Samadi ◽  
Jamshid Karimi ◽  
Neda Hosseinpour Moghadam ◽  
...  

2020 ◽  
Vol 27 ◽  
Author(s):  
Hamid Tanzadehpanah ◽  
Hanie Mahaki ◽  
Mohammadreza Moradi ◽  
Saeid Afshar ◽  
Neda Hosseinpour Moghadam ◽  
...  

Background: Interactions of drugs with DNA and proteins may modify their biological activities and conformations, which effect transport and biological metabolism of drugs. Objective: In this study the interaction of anticancer drug regorafenib (REG) with calf thymus-DNA (ct-DNA) and human serum albumin (HSA) has been investigated. Methods: Hence, for the first time, it was discovered interaction between REG with DNA and HSA using multispectroscopic, zeta potential measurements and molecular docking method. Results and Discussion: DNA displacement studies showed that REG does not have any effect on acridine orange and methylene blue bound DNA, though it was substantiated by displacement studies with Hoechst (as groove binder). Furthermore, the different concentrations of REG induce slight changes in the viscosity of ct-DNA. Zeta potential parameters indicated that hydrophobic interaction plays a major role in the DNA-REG complex. Results obtained from molecular docking demonstrate that the REG prefers to bind on the minor groove of DNAs than that of the major groove. Binding properties of HSA reveal that intrinsic fluorescence of HSA could be quenched by REG in a static mode. The competitive experiments in the presence of warfarin and ibuprofen (as site markers) suggested that the binding site of REG to HSA was most probably located in the subdomain IIA. Measurements of the zeta potential indicated that REG bound to HSA mainly by both electrostatic and hydrophobic interactions. It was found on docking procedures that REG could fit well into HSA subdomain IIA, which confirmed the experimental results. Conclusion: In conclusion, REG can be delivered by HSA in a circulatory system and affect DNA as potential target.


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