scholarly journals Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies

Nanoscale ◽  
2015 ◽  
Vol 7 (9) ◽  
pp. 3817-3837 ◽  
Author(s):  
Mijanur Rahaman Molla ◽  
Poornima Rangadurai ◽  
Giovanni M. Pavan ◽  
S. Thayumanavan
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Macromolecular Assemblies ◽  
Drug Molecules ◽  
Theoretical Investigations ◽  
Drug Delivery Applications

Stimuli-responsive macromolecular assemblies are of great interest in drug delivery applications, as it holds the promise to keep the drug molecules sequestered under one set of conditions and release them under another.

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

Effects of Co-Solvents on Loading and Release Properties of Self-Assembled Di-Peptide Building Blocks, towards Drug Delivery Applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Sara Yazdani ◽  
Seyed Mohammad Ghoreishi ◽  
Neda Habibi
Keyword(s):  
Drug Delivery ◽  
Building Blocks ◽  
Amino Acid Sequences ◽  
Molecular Structures ◽  
Flufenamic Acid ◽  
Mixture Ratio ◽  
Drug Molecules ◽  
Release Capacity ◽  
Essential Properties ◽  
Drug Delivery Applications

Background: Due to their solid-like porous structure, molecular organogel and microcrystal structures have the capabilities of loading drug molecules, encapsulation, and extended release, all considered as essential properties in drug delivery applications. Phases of these structures, however, depend on the solvent used during the gelation process. Objective: Understanding the phase transition between organogel and microcrystal structures through adjusting the mixture ratio of different co-solvents. Method: Short peptide Diphenylalanine as the gelation building block was used due to its amino acid sequences that can be exactly selected at its molecular levels. Ethanol as a polar solvent was used in combination with four other co-solvents with different polarity levels, namely Xylene, Toluene, Acetone, and Dimethyl Sulfoxide. The morphology of molecular structures of each co-solvent combination at each ratio level was examined as well as the loading and release properties for a non-polar Flufenamic Acid drug. Results: The resultant structure wasaffected by the polarity of the co-solvents; in particular, in the sample containing 25 μg/ml of the drug, 94% of the drug amount was loaded inside the organogel. By increasing the drug concentration to 50, 75, and 100 μg/ml, the loading capability decreased to 76%, 47%, and 33%, respectively. Conclusion: Molecular organogels have excellent capabilities of loading drug molecules, while microcrystal structures have higher release capacity. The findings of this study reveal how to best design a gelation method to obtain maximum loading or release properties for a particular peptide-based drug delivery application.

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Interfacial properties of POPC/GDO liquid crystalline nanoparticles deposited on anionic and cationic silica surfaces

2016 ◽  
Vol 18 (38) ◽  
pp. 26630-26642 ◽  
Author(s):  
Debby P. Chang ◽  
Aleksandra P. Dabkowska ◽  
Richard A. Campbell ◽  
Maria Wadsäter ◽  
Justas Barauskas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystalline ◽  
Interfacial Properties ◽  
High Potential ◽  
Silica Surfaces ◽  
Drug Molecules ◽  
Hydrophilic Drug ◽  
Liquid Crystalline Nanoparticles ◽  
Drug Delivery Applications

Reversed lipid liquid crystalline nanoparticles (LCNPs) of the cubic micellar (I2) phase have high potential in drug delivery applications due to their ability to encapsulate both hydrophobic and hydrophilic drug molecules.

Stimuli responsive hydrogels derived from a renewable resource: synthesis, self-assembly in water and application in drug delivery

2015 ◽  
Vol 3 (27) ◽  
pp. 5560-5568 ◽  
Author(s):  
Krishnamoorthy Lalitha ◽  
Y. Siva Prasad ◽  
C. Uma Maheswari ◽  
Vellaisamy Sridharan ◽  
George John ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Renewable Resource ◽  
Stimuli Responsive ◽  
Composite Gel ◽  
Drug Delivery Applications ◽  
Responsive Hydrogels

We report coumarin-tris based hydrogel and curcumin encapsulated composite gel for stimuli responsive drug delivery applications.

scholarly journals Peptide Self-Assembled Nanostructures for Drug Delivery Applications

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Taotao Fan ◽  
Xiaoyan Yu ◽  
Bing Shen ◽  
Leming Sun
Keyword(s):  
Drug Delivery ◽  
Low Cost ◽  
Drug Loading ◽  
Chemical Diversity ◽  
Stimuli Responsive ◽  
Different Types ◽  
Good Biocompatibility ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Underlying Mechanisms

Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at disease sites. Peptide self-assembled nanostructures such as nanoparticles, nanotubes, nanofibers, and hydrogels have been investigated by many researchers for drug delivery applications. In this review, the underlying mechanisms for the self-assembled nanostructures based on peptides with different types and structures are introduced and discussed. Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery applications are also reviewed and discussed.

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