scholarly journals Potentiation of photoinactivation of Gram-positive and Gram-negative bacteria mediated by six phenothiazinium dyes by addition of azide ion

2014 ◽  
Vol 13 (11) ◽  
pp. 1541-1548 ◽  
Author(s):  
Kamola R. Kasimova ◽  
Magesh Sadasivam ◽  
Giacomo Landi ◽  
Tadeusz Sarna ◽  
Michael R. Hamblin
Keyword(s):  
Singlet Oxygen ◽  
Hydroxyl Radicals ◽  
Gram Negative Bacteria ◽  
Photodynamic Inactivation ◽  
Gram Positive ◽  
Gram Negative ◽  
Azide Ion

Antimicrobial photodynamic inactivation (APDI) using six different phenothiazinium dyes is mediated by singlet oxygen (quenched by azide) and hydroxyl radicals (potentiated by azide) depending on Gram-classification of the bacteria and whether the dye is washed from the cells.

scholarly journals Water-dispersible glycosylated poly(2,5′-thienylene)porphyrin-based nanoparticles for antibacterial photodynamic therapy

2019 ◽  
Vol 18 (5) ◽  
pp. 1147-1155 ◽  
Author(s):  
Rehan Khan ◽  
Melis Özkan ◽  
Aisan Khaligh ◽  
Dönüs Tuncel
Keyword(s):  
Antibacterial Activity ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli ◽  
Water Dispersible ◽  
Gram Positive Bacteria ◽  
High Yields

Water-dispersible glycosylated poly(2,5′-thienylene)porphyrin-based nanoparticles have the ability to generate singlet oxygen in high yields and exhibit light-triggered antibacterial activity against Gram negative bacteria, E. coli as well as Gram positive bacteria, B. subtilis.

scholarly journals Chitosan Augments Photodynamic Inactivation of Gram-Positive and Gram-Negative Bacteria

2011 ◽  
Vol 55 (5) ◽  
pp. 1883-1890 ◽  
Author(s):  
Tsuimin Tsai ◽  
Hsiung-Fei Chien ◽  
Tze-Hsien Wang ◽  
Ching-Tsan Huang ◽  
Yaw-Bee Ker ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Light Exposure ◽  
Gram Negative Bacteria ◽  
Photodynamic Inactivation ◽  
Gram Positive ◽  
Gram Negative ◽  
Content Type ◽  
Gram Positive Bacteria ◽  
Microbial Infections ◽  
Promising Treatment

ABSTRACTAntimicrobial photodynamic inactivation (PDI) was shown to be a promising treatment modality for microbial infections. This study explores the effect of chitosan, a polycationic biopolymer, in increasing the PDI efficacy against Gram-positive bacteria, includingStaphylococcus aureus,Staphylococcus epidermidis,Streptococcus pyogenes, and methicillin-resistantS. aureus(MRSA), as well as the Gram-negative bacteriaPseudomonas aeruginosaandAcinetobacter baumannii. Chitosan at <0.1% was included in the antibacterial process either by coincubation with hematoporphyrin (Hp) and subjection to light exposure to induce the PDI effect or by addition after PDI and further incubation for 30 min. Under conditions in which Hp-PDI killed the microbe on a 2- to 4-log scale, treatment with chitosan at concentrations of as low as 0.025% for a further 30 min completely eradicated the bacteria (which were originally at ∼108CFU/ml). Similar results were also found with toluidine blue O (TBO)-mediated PDI in planktonic and biofilm cells. However, without PDI treatment, chitosan alone did not exert significant antimicrobial activity with 30 min of incubation, suggesting that the potentiated effect of chitosan worked after the bacterial damage induced by PDI. Further studies indicated that the potentiated PDI effect of chitosan was related to the level of PDI damage and the deacetylation level of the chitosan. These results indicate that the combination of PDI and chitosan is quite promising for eradicating microbial infections.

scholarly journals Protochlorophyllide: a new photosensitizer for the photodynamic inactivation of Gram-positive and Gram-negative bacteria

2008 ◽  
Vol 290 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Johannes Walther ◽  
Markus J. Bröcker ◽  
Denise Wätzlich ◽  
Manfred Nimtz ◽  
Manfred Rohde ◽  
...  
Keyword(s):  
Gram Negative Bacteria ◽  
Photodynamic Inactivation ◽  
Gram Positive ◽  
Gram Negative

scholarly journals Sodium nitrite potentiates antimicrobial photodynamic inactivation: possible involvement of peroxynitrate

2019 ◽  
Vol 18 (2) ◽  
pp. 505-515 ◽  
Author(s):  
Ying-Ying Huang ◽  
Paweł J. Rajda ◽  
Grzegorz Szewczyk ◽  
Brijesh Bhayana ◽  
Long Y. Chiang ◽  
...  
Keyword(s):  
Sodium Nitrite ◽  
Gram Negative Bacteria ◽  
Photodynamic Inactivation ◽  
Gram Positive ◽  
Gram Negative

Antimicrobial photodynamic inactivation using different photosensitizers of Gram-positive and Gram-negative bacteria can be potentiated up to one million times by addition of sodium nitrite. The mechanism is proposed to involve formation of peroxynitrate.

Antimicrobial activity against Gram-positive and Gram-negative bacteria during gatifloxacin degradation by hydroxyl radicals

2016 ◽  
Vol 24 (7) ◽  
pp. 6288-6298 ◽  
Author(s):  
Marlon Caianelo ◽  
Caio Rodrigues-Silva ◽  
Milena Guedes Maniero ◽  
José Roberto Guimarães
Keyword(s):  
Antimicrobial Activity ◽  
Hydroxyl Radicals ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative

Effect of extracellularly generated singlet oxygen on Gram-positive and Gram-negative bacteria

1993 ◽  
Vol 21 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Giuliana Valduga ◽  
Giulio Bertoloni ◽  
Elena Reddi ◽  
Giulio Jori
Keyword(s):  
Singlet Oxygen ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative

scholarly journals BODIPY-embedded electrospun materials in antimicrobial photodynamic inactivation

2019 ◽  
Vol 18 (8) ◽  
pp. 1923-1932 ◽  
Author(s):  
Kevin R. Stoll ◽  
Frank Scholle ◽  
Jiadeng Zhu ◽  
Xiangwu Zhang ◽  
Reza A. Ghiladi
Keyword(s):  
Gram Negative Bacteria ◽  
Photodynamic Inactivation ◽  
Drug Resistant ◽  
Detection Level ◽  
Gram Positive ◽  
Gram Negative

Electrospun BODIPY(+)-embedded nanofiber materials were capable of the detection-level photodynamic inactivation of drug-resistant Gram-positive and Gram-negative bacteria and viruses.

scholarly journals Fluorine-substituted tetracationic ABAB-phthalocyanines for efficient photodynamic inactivation of Gram-positive and Gram-negative bacteria

2020 ◽  
Vol 187 ◽  
pp. 111957 ◽  
Author(s):  
Miguel Á. Revuelta-Maza ◽  
Patricia González-Jiménez ◽  
Cormac Hally ◽  
Montserrat Agut ◽  
Santi Nonell ◽  
...  
Keyword(s):  
Gram Negative Bacteria ◽  
Photodynamic Inactivation ◽  
Gram Positive ◽  
Gram Negative
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