pH-responsive dendritic polyrotaxane drug-polymer conjugates forming nanoparticles as efficient drug delivery system for cancer therapy

2015 ◽  
Vol 6 (11) ◽  
pp. 2098-2107 ◽  
Author(s):  
Yang Kang ◽  
Xiao-Mei Zhang ◽  
Sheng Zhang ◽  
Li-Sheng Ding ◽  
Bang-Jing Li
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Polymer Conjugates

pH stimuli-responsive controlled selective release of drugs at the endosomal compartments of the PR-g-DOX supramolecular micelles.

scholarly journals A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy

2020 ◽  
Vol Volume 15 ◽  
pp. 65-80 ◽  
Author(s):  
Chen Xu ◽  
Rijin Song ◽  
Pei Lu ◽  
Jianchun Chen ◽  
Yongqiang Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ros Generation ◽  
Specific Drug ◽  
Ph Responsive ◽  
Charge Reversal

Ecofriendly one pot fabrication of methyl gallate@ZIF-L nanoscale hybrid as pH responsive drug delivery system for lung cancer therapy

2019 ◽  
Vol 84 ◽  
pp. 39-52 ◽  
Author(s):  
Prabhu R. ◽  
Mohamed Asik R. ◽  
Anjali R. ◽  
Archunan G. ◽  
Prabhu N.M. ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Methyl Gallate ◽  
Ph Responsive ◽  
One Pot ◽  
Lung Cancer Therapy

A pH-responsive AIE nanoprobe as a drug delivery system for bioimaging and cancer therapy

2015 ◽  
Vol 3 (37) ◽  
pp. 7401-7407 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Shihua Dong ◽  
Junjie Xiong ◽  
Zongliang Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cellular Imaging ◽  
Ph Responsive ◽  
Triggered Drug Release

A multifunctional drug delivery system with AIE character was designed and constructed for simultaneous cellular imaging and pH-triggered drug release.

scholarly journals A pH-Responsive Zwitterionic Polyurethane Prodrug as Drug Delivery System for Enhanced Cancer Therapy

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5274
Author(s):  
Qian He ◽  
Rui Yan ◽  
Wanting Hou ◽  
Haibo Wang ◽  
Yali Tian
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Cellular Uptake ◽  
Delivery System ◽  
Antitumor Drug ◽  
Control Group ◽  
Ph Responsive ◽  
Cytotoxicity Studies

Numerous nanocarriers with excellent biocompatibilities have been used to improve cancer therapy. However, nonspecific protein adsorption of nanocarriers may block the modified nanoparticles in tumor cells, which would lead to inefficient cellular internalization. To address this issue, pH-responsive polyurethane prodrug micelles with a zwitterionic segment were designed and prepared. The micelle consisted of a zwitterionic segment as the hydrophilic shell and the drug Adriamycin (DOX) as the hydrophobic inner core. As a pH-responsive antitumor drug delivery system, the prodrug micelles showed high stability in a physiological environment and continuously released the drug under acidic conditions. In addition, the pure polyurethane carrier was demonstrated to be virtually non-cytotoxic by cytotoxicity studies, while the prodrug micelles were more efficient in killing tumor cells compared to PEG-PLGA@DOX. Furthermore, the DOX cellular uptake efficiency of prodrug micelles was proved to be obviously higher than the control group by both flow cytometry and fluorescence microscopy. This is mainly due to the modification of a zwitterionic segment with PU. The simple design of zwitterionic prodrug micelles provides a new strategy for designing novel antitumor drug delivery systems with enhanced cellular uptake rates.

Mesoporous Si‐MCM‐41/Polymer as a pH‐Responsive Drug Delivery System for Cancer Therapy

2020 ◽  
Vol 5 (38) ◽  
pp. 11901-11909
Author(s):  
Mina Maghsoudi ◽  
Mojtaba Abbasian ◽  
Khalil Farhadi ◽  
Farideh Mahmoodzadeh ◽  
Marjan Ghorbani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Mcm 41

Dendronized heparin−doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy

Biomaterials ◽  
2013 ◽  
Vol 34 (9) ◽  
pp. 2252-2264 ◽  
Author(s):  
Wenchuan She ◽  
Ning Li ◽  
Kui Luo ◽  
Chunhua Guo ◽  
Gang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive

Bioinspired phospholipid polymer prodrug as a pH-responsive drug delivery system for cancer therapy

2013 ◽  
Vol 4 (6) ◽  
pp. 2004 ◽  
Author(s):  
Haibo Wang ◽  
Fangming Xu ◽  
Dandan Li ◽  
Xiangsheng Liu ◽  
Qiao Jin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Phospholipid Polymer
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