Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 30023-30031 ◽  
Author(s):  
N. H. N. Kamarudin ◽  
A. A. Jalil ◽  
S. Triwahyono ◽  
M. R. Sazegar ◽  
S. Hamdan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Acid Strength ◽  
Ft Ir ◽  
Adsorption And Release ◽  
Strength Effect

Mesoporous silica nanoparticles (MSN) with 1–10 wt% loading of aluminum (Al) were prepared and characterized by XRD, N2 physisorption, 29Si and 27Al NMR, FT-IR and FT-IR preadsorbed pyridine.

Synthesis and Characterization of Thiol- and Carboxyl-Functionalized Mesoporous Silica Nanoparticles

2017 ◽  
Vol 1142 ◽  
pp. 220-224 ◽  
Author(s):  
Wan Xia Wang ◽  
Yu Wang ◽  
Hua Meng Gong ◽  
Hong Hao Sun ◽  
Ming Xing Liu
Keyword(s):  
Electron Microscopy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Spherical Shape ◽  
Synthesis And Characterization ◽  
Functionalized Mesoporous Silica ◽  
Transmission Electron ◽  
Ft Ir

The purpose of this article is to synthesize the thiol-and carboxyl-bifunctionalized mesoporous silica nanoparticles (CMS-SH-COOH). CMS-SH-COOH was successfully synthesized by co-condensation and post-grafting methods. Moreover, the particle size and structural properties of CMS-SH-COOH were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FT-IR). The obtained results indicated that the CMS-SH-COOH presented a uniform spherical shape with a wormhole arrangement of the mesopores and a relatively narrow paticle distribition. Therefore, the CMS-SH-COOH might be a great potential carrier for the drug delivery system in the future.

Mesoporous Silica Nanoparticles and Waste Derived-Siliceous Materials for Doxorubicin Adsorption and Release

2019 ◽  
Vol 19 ◽  
pp. 1420-1425
Author(s):  
Jafreena Adira Jaafar ◽  
Nur Hidayatul Nazirah Kamarudin ◽  
Herma Dina Setiabudi ◽  
Sharifah Najiha Timmiati ◽  
Teh Lee Peng
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Adsorption And Release

scholarly journals Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine

2021 ◽  
Vol 22 (14) ◽  
pp. 7665
Author(s):  
Cristina Carucci ◽  
Nicola Scalas ◽  
Andrea Porcheddu ◽  
Marco Piludu ◽  
Maura Monduzzi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Intermolecular Interactions ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Lower Surface ◽  
Burst Release ◽  
Vis Spectroscopy ◽  
Adsorption And Release

Mesoporous silica nanoparticles (MSN) were synthesised and functionalised with triethylenetetramine (MSN-TETA). The samples were fully characterised (transmission electron microscopy, small angle X-ray scattering, Fourier transform infrared spectroscopy, thermogravimetric analysis, zeta potential and nitrogen adsorption/desorption isotherms) and used as carriers for the adsorption of the antimicrobial drug sulphamethizole (SMZ). SMZ loading, quantified by UV–Vis spectroscopy, was higher on MSN-TETA (345.8 mg g−1) compared with bare MSN (215.4 mg g−1) even in the presence of a lower surface area (671 vs. 942 m2 g−1). The kinetics of SMZ adsorption on MSN and MSN-TETA followed a pseudo-second-order model. The adsorption isotherm is described better by a Langmuir model rather than a Temkin or Freundlich model. Release kinetics showed a burst release of SMZ from bare MSN samples (k1 = 136 h−1) in contrast to a slower release found with MSN-TETA (k1 = 3.04 h−1), suggesting attractive intermolecular interactions slow down SMZ release from MSN-TETA. In summary, the MSN surface area did not influence SMZ adsorption and release. On the contrary, the design of an effective drug delivery system must consider the intermolecular interactions between the adsorbent and the adsorbate.

scholarly journals Concept Design, Development and Preliminary Physical and Chemical Characterization of Tamoxifen-Guided-Mesoporous Silica Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 219
Author(s):  
Candace M. Day ◽  
Martin J. Sweetman ◽  
Shane M. Hickey ◽  
Yunmei Song ◽  
Yongjun Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
New Technologies ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Building Blocks ◽  
Concept Design ◽  
Design Development ◽  
Breast Tumours ◽  
Ft Ir

Conventional chemotherapies used for breast cancer (BC) treatment are non-selective, attacking both healthy and cancerous cells. Therefore, new technologies that enhance drug efficacy and ameliorate the off-target toxic effects exhibited by currently used anticancer drugs are urgently needed. Here we report the design and synthesis of novel mesoporous silica nanoparticles (MSNs) equipped with the hormonal drug tamoxifen (TAM) to facilitate guidance towards estrogen receptors (ERs) which are upregulated in breast tumours. TAM is linked to the MSNs using a poly-ʟ-histidine (PLH) polymer as a pH-sensitive gatekeeper, to ensure efficient delivery of encapsulated materials within the pores. XRD, HR-TEM, DLS, SEM, FT-IR and BET techniques were used to confirm the successful fabrication of MSNs. The MSNs have a high surface area (>1000 m2/g); and a mean particle size of 150 nm, which is an appropriate size to allow the penetration of premature blood vessels surrounding breast tumours. Successful surface functionalization was supported by FT-IR, XPS and TGA techniques, with a grafting ratio of approximately 29%. The outcomes of this preliminary work could be used as practical building blocks towards future formulations.

Adsorption and Release of 5-Fluorouracil (5FU) from Mesoporous Silica Nanoparticles

2019 ◽  
Vol 19 ◽  
pp. 1722-1729 ◽  
Author(s):  
Nur Syazaliyana Azali ◽  
Nur Hidayatul Nazirah Kamarudin ◽  
Ainul Rasyidah Abdul Rahim ◽  
Norzaidhatul Syifa'a Jamal Nasir ◽  
Sharifah Najiha Timmiati ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Adsorption And Release

Influence of mesopore size and peptide aggregation on the adsorption and release of a model antimicrobial peptide onto/from mesoporous silica nanoparticles in vitro

2017 ◽  
Vol 2 (4) ◽  
pp. 393-400 ◽  
Author(s):  
Katharina Braun ◽  
Alexander Pochert ◽  
Marlena Gerber ◽  
Heinz Fabian Raber ◽  
Mika Lindén
Keyword(s):  
Mesoporous Silica ◽  
Antimicrobial Peptide ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Peptide Aggregation ◽  
Adsorption And Release

The interplay between mesopore size and degree of peptide aggregation controls both calcitonin adsorption onto and release from mesoporous silica nanoparticles.

Adsorption and release of biocides with mesoporous silica nanoparticles

Nanoscale ◽  
2012 ◽  
Vol 4 (3) ◽  
pp. 970-975 ◽  
Author(s):  
Amirali Popat ◽  
Jian Liu ◽  
Qiuhong Hu ◽  
Michael Kennedy ◽  
Brenton Peters ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Adsorption And Release
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