Boronic acid recognition based-gold nanoparticle-labeling strategy for the assay of sialic acid expression on cancer cell surface by inductively coupled plasma mass spectrometry

The Analyst ◽  
2016 ◽  
Vol 141 (4) ◽  
pp. 1286-1293 ◽  
Author(s):  
Xing Zhang ◽  
Beibei Chen ◽  
Man He ◽  
Yuan Zhang ◽  
Lu Peng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sialic Acid ◽  
Cell Surface ◽  
Cancer Cell ◽  
Boronic Acid ◽  
Inductively Coupled Plasma ◽  
Normal Cell ◽  
Sialic Acids ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

Sialic acids are special sugars widely expressed at the termini of glycan chains on the cell surface, and their expression level on the cancer cell surface is much higher than on the normal cell surface.

scholarly journals Quantification of silver nanoparticles taken up by single cells using inductively coupled plasma mass spectrometry in the single cell measurement mode

2018 ◽  
Vol 33 (7) ◽  
pp. 1256-1263 ◽  
Author(s):  
Ana López-Serrano Oliver ◽  
Sabine Baumgart ◽  
Wolfram Bremser ◽  
Sabine Flemig ◽  
Doreen Wittke ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Silver Nanoparticles ◽  
Cell Surface ◽  
Inductively Coupled Plasma ◽  
Single Cells ◽  
Analytical Methodology ◽  
Inductively Coupled ◽  
Cell Measurement ◽  
Measurement Mode ◽  
Plasma Mass Spectrometry

A promising analytical methodology is proposed to study nanoparticle-cell interactions providing information of the number of NPs internalized by cells or externally bound to the cell surface.

Single Particle Inductively Coupled Plasma Mass Spectrometry: Investigating Nonlinear Response Observed in Pulse Counting Mode and Extending the Linear Dynamic Range by Compensating for Dead Time Related Count Losses on a Microsecond Timescale

2019 ◽  
Author(s):  
Ingo Strenge ◽  
Carsten Engelhard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Nonlinear Response ◽  
Dynamic Range ◽  
Dead Time ◽  
Inorganic Nanoparticles ◽  
Linear Dynamic Range ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

<p>The article demonstrates the importance of using a suitable approach to compensate for dead time relate count losses (a certain measurement artefact) whenever short, but potentially strong transient signals are to be analysed using inductively coupled plasma mass spectrometry (ICP-MS). Findings strongly support the theory that inadequate time resolution, and therefore insufficient compensation for these count losses, is one of the main reasons for size underestimation observed when analysing inorganic nanoparticles using ICP-MS, a topic still controversially discussed.</p>

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