Scaling up an electrochemical signal with a catalytic hairpin assembly coupling nanocatalyst label for DNA detection

A new strategy for the electrochemical detection of DNA based on catalytic hairpin assembly combined with nanocatalyst label-based redox cycling reaction signal amplification. A superior detection limit of 0.3 aM toward DNA was achieved.

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In Vivo Two-Way Redox Cycling System for Independent Duplexed Electrochemical Signal Amplification

Analytical Chemistry ◽

10.1021/acs.analchem.9b00053 ◽

2019 ◽

Vol 91 (8) ◽

pp. 4939-4942 ◽

Cited By ~ 6

Author(s):

Yuan Yang ◽

Yang-Yang Yu ◽

Yu-Tong Shi ◽

Jamile Mohammadi Moradian ◽

Yang-Chun Yong

Keyword(s):

Signal Amplification ◽

Redox Cycling ◽

Electrochemical Signal ◽

Cycling System

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Electrochemical detection of microRNA based on SA-PPy/AuNPs nanocomposite with the signal amplification through catalytic hairpin assembly reaction and the spontaneous catalytic reaction of Fe3+/Cu2+

Electrochimica Acta ◽

10.1016/j.electacta.2020.137168 ◽

2020 ◽

Vol 362 ◽

pp. 137168 ◽

Cited By ~ 1

Author(s):

Xiangyu Ma ◽

Kun Qian ◽

Onome Ejeromedoghene ◽

Martha Kandawa-Schulz ◽

Yihong Wang

Keyword(s):

Electrochemical Detection ◽

Catalytic Reaction ◽

Signal Amplification ◽

Catalytic Hairpin Assembly

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Electrochemical detection of amyloid-β oligomer with the signal amplification of alkaline phosphatase plus electrochemical–chemical–chemical redox cycling

Journal of Electroanalytical Chemistry ◽

10.1016/j.jelechem.2015.06.017 ◽

2015 ◽

Vol 754 ◽

pp. 40-45 ◽

Cited By ~ 24

Author(s):

Lin Liu ◽

Ning Xia ◽

Mengsha Jiang ◽

Nanbing Huang ◽

Shuo Guo ◽

...

Keyword(s):

Alkaline Phosphatase ◽

Electrochemical Detection ◽

Signal Amplification ◽

Amyloid Β ◽

Redox Cycling

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Highly sensitive and label-free electrochemical detection of microRNAs based on triple signal amplification of multifunctional gold nanoparticles, enzymes and redox-cycling reaction

Biosensors and Bioelectronics ◽

10.1016/j.bios.2013.10.026 ◽

2014 ◽

Vol 53 ◽

pp. 399-405 ◽

Cited By ~ 108

Author(s):

Lin Liu ◽

Ning Xia ◽

Huiping Liu ◽

Xiaojing Kang ◽

Xiaoshuan Liu ◽

...

Keyword(s):

Gold Nanoparticles ◽

Electrochemical Detection ◽

Signal Amplification ◽

Redox Cycling ◽

Label Free ◽

Highly Sensitive

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High Electrochemical Signal Amplification Using a Propagating Cascade Reaction and a Redox Cycling Reaction

ECS Meeting Abstracts ◽

10.1149/ma2020-01452583mtgabs ◽

2020 ◽

Vol MA2020-01 (45) ◽

pp. 2583-2583

Author(s):

Haesik Yang ◽

Kiryeon Park

Keyword(s):

Signal Amplification ◽

Redox Cycling ◽

Cascade Reaction ◽

Electrochemical Signal

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Electrochemical detection of DNA by using “Pd/GO label copper stain” for signal amplification

Analytical Methods ◽

10.1039/c5ay02369f ◽

2015 ◽

Vol 7 (20) ◽

pp. 8554-8560 ◽

Cited By ~ 2

Author(s):

Zhifei Wang ◽

Jingjing Yang ◽

Yanyun Jiang ◽

Yuanyin Zhang ◽

Liming Zhang ◽

...

Keyword(s):

Electrochemical Detection ◽

Signal Amplification ◽

Copper Ions ◽

Metallic Copper ◽

New Strategy

A new strategy for signal amplification by labeling DNA with Pd/GO nanoparticles, which further act as catalysts to reduce copper ions to metallic copper to enhance the signal, is presented.

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Ultrasensitive electrochemical detection of microRNA based on in-situ catalytic hairpin assembly actuated DNA tetrahedral interfacial probes

Talanta ◽

10.1016/j.talanta.2021.122600 ◽

2021 ◽

pp. 122600

Author(s):

Zhangcheng Fu ◽

Tong Lv ◽

Lili jiang ◽

Chao Xing ◽

Chunhua Lu

Keyword(s):

Electrochemical Detection ◽

Catalytic Hairpin Assembly

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A double signal amplification-based homogeneous electrochemical sensor built on catalytic hairpin assembly and bisferrocene markers

Analytical Biochemistry ◽

10.1016/j.ab.2021.114140 ◽

2021 ◽

pp. 114140

Author(s):

Hai yong Cao ◽

Bo Lu ◽

Lin Cheng ◽

Bin xiang Xu ◽

Mei Wang ◽

...

Keyword(s):

Electrochemical Sensor ◽

Signal Amplification ◽

Catalytic Hairpin Assembly

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Electrochemical detection of telomerase in cancer cells based on the in-situ formation of streptavidin-biotin-DNA-biotin networks for signal amplification

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2021.129659 ◽

2021 ◽

Vol 334 ◽

pp. 129659

Author(s):

Lin Liu ◽

Daohong Wu ◽

Shuang Zhen ◽

Kaiqing Lu ◽

Xinyao Yi ◽

...

Keyword(s):

Cancer Cells ◽

Electrochemical Detection ◽

Signal Amplification ◽

In Situ Formation

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Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection

Chemosensors ◽

10.3390/chemosensors9040085 ◽

2021 ◽

Vol 9 (4) ◽

pp. 85

Author(s):

Anton Popov ◽

Benediktas Brasiunas ◽

Asta Kausaite-Minkstimiene ◽

Almira Ramanaviciene

Keyword(s):

Signal Amplification ◽

Electrochemical Immunosensor ◽

Metal Nanoparticle ◽

Biomarker Detection ◽

Analytical Instruments ◽

Electrochemical Immunosensors ◽

Highly Sensitive ◽

Recent Developments ◽

Electrochemical Signal ◽

Detection Of Biomarkers

With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed.

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