High Electrochemical Signal Amplification Using a Propagating Cascade Reaction and a Redox Cycling Reaction

2020 ◽  
Vol MA2020-01 (45) ◽  
pp. 2583-2583
Author(s):  
Haesik Yang ◽  
Kiryeon Park
Keyword(s):  
Signal Amplification ◽  
Redox Cycling ◽  
Cascade Reaction ◽  
Electrochemical Signal

scholarly journals In Vivo Two-Way Redox Cycling System for Independent Duplexed Electrochemical Signal Amplification

2019 ◽  
Vol 91 (8) ◽  
pp. 4939-4942 ◽  
Author(s):  
Yuan Yang ◽  
Yang-Yang Yu ◽  
Yu-Tong Shi ◽  
Jamile Mohammadi Moradian ◽  
Yang-Chun Yong
Keyword(s):  
Signal Amplification ◽  
Redox Cycling ◽  
Electrochemical Signal ◽  
Cycling System

Scaling up an electrochemical signal with a catalytic hairpin assembly coupling nanocatalyst label for DNA detection

2015 ◽  
Vol 51 (33) ◽  
pp. 7100-7103 ◽  
Author(s):  
Xu Hun ◽  
Guoliang Xie ◽  
Xiliang Luo
Keyword(s):  
Detection Limit ◽  
Electrochemical Detection ◽  
Signal Amplification ◽  
Dna Detection ◽  
Scaling Up ◽  
Redox Cycling ◽  
New Strategy ◽  
Electrochemical Signal ◽  
Catalytic Hairpin Assembly

A new strategy for the electrochemical detection of DNA based on catalytic hairpin assembly combined with nanocatalyst label-based redox cycling reaction signal amplification. A superior detection limit of 0.3 aM toward DNA was achieved.

scholarly journals Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection

Chemosensors ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 85
Author(s):  
Anton Popov ◽  
Benediktas Brasiunas ◽  
Asta Kausaite-Minkstimiene ◽  
Almira Ramanaviciene
Keyword(s):  
Signal Amplification ◽  
Electrochemical Immunosensor ◽  
Metal Nanoparticle ◽  
Biomarker Detection ◽  
Analytical Instruments ◽  
Electrochemical Immunosensors ◽  
Highly Sensitive ◽  
Recent Developments ◽  
Electrochemical Signal ◽  
Detection Of Biomarkers

With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed.

scholarly journals Photoelectrochemical-Chemical-Chemical Redox Cycling for Advanced Signal Amplification: Proof-of-Concept Toward Ultrasensitive Photoelectrochemical Bioanalysis

2018 ◽  
Vol 90 (21) ◽  
pp. 12347-12351 ◽  
Author(s):  
Bing Wang ◽  
Li-Ping Mei ◽  
Yan Ma ◽  
Yi-Tong Xu ◽  
Shu-Wei Ren ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Redox Cycling ◽  
Proof Of Concept

scholarly journals DNA/RNA Electrochemical Biosensing Devices a Future Replacement of PCR Methods for a Fast Epidemic Containment

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4648 ◽  
Author(s):  
Manikandan Santhanam ◽  
Itay Algov ◽  
Lital Alfonta
Keyword(s):  
Signal Amplification ◽  
Nucleic Acid Hybridization ◽  
Diagnostic Tools ◽  
Testing Method ◽  
Reverse Transcription Pcr ◽  
Electrochemical Biosensing ◽  
Low Copy Number ◽  
Rna Sensors ◽  
Electrochemical Signal ◽  
Sensitive Testing

Pandemics require a fast and immediate response to contain potential infectious carriers. In the recent 2020 Covid-19 worldwide pandemic, authorities all around the world have failed to identify potential carriers and contain it on time. Hence, a rapid and very sensitive testing method is required. Current diagnostic tools, reverse transcription PCR (RT-PCR) and real-time PCR (qPCR), have its pitfalls for quick pandemic containment such as the requirement for specialized professionals and instrumentation. Versatile electrochemical DNA/RNA sensors are a promising technological alternative for PCR based diagnosis. In an electrochemical DNA sensor, a nucleic acid hybridization event is converted into a quantifiable electrochemical signal. A critical challenge of electrochemical DNA sensors is sensitive detection of a low copy number of DNA/RNA in samples such as is the case for early onset of a disease. Signal amplification approaches are an important tool to overcome this sensitivity issue. In this review, the authors discuss the most recent signal amplification strategies employed in the electrochemical DNA/RNA diagnosis of pathogens.

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