Copper(i) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode

2016 ◽  
Vol 45 (12) ◽  
pp. 5052-5063 ◽  
Author(s):  
U. K. Komarnicka ◽  
R. Starosta ◽  
M. Płotek ◽  
R. F. M. de Almeida ◽  
M. Jeżowska-Bojczuk ◽  
...  
Keyword(s):  
Cytotoxic Action ◽  
Antibiotic Agent ◽  
Action Mode ◽  
Thiocyanate Complexes ◽  
Fluoroquinolone Antibiotic ◽  
Insight Into

A first insight into the cytotoxic action mode of copper(i) iodide or copper(i) thiocyanate complexes with a phosphine derivative of sparfloxacin (a 3rdgeneration fluoroquinolone antibiotic agent) and 2,9-dimethyl-1,10-phenanthroline or 2,2′-biquinoline as auxiliary ligands.

Cytotoxic action mode of a novel porphyrin derivative isolated from harmful red tide dinoflagellateHeterocapsa circularisquama

2008 ◽  
Vol 22 (3) ◽  
pp. 158-165 ◽  
Author(s):  
Daekyung Kim ◽  
Yousuke Miyazaki ◽  
Takuji Nakashima ◽  
Takashi Iwashita ◽  
Tsuyoshi Fujita ◽  
...  
Keyword(s):  
Red Tide ◽  
Cytotoxic Action ◽  
Porphyrin Derivative ◽  
Action Mode

Safety Pharmacology of DW‐224a, A Novel Fluoroquinolone Antibiotic Agent

2004 ◽  
Vol 27 (4) ◽  
pp. 295-307 ◽  
Author(s):  
Eun‐Joo Kim ◽  
Won‐Ho Shin ◽  
Ki‐Suk Kim ◽  
Sang‐Seop Han
Keyword(s):  
Antibiotic Agent ◽  
Safety Pharmacology ◽  
Fluoroquinolone Antibiotic

Some insight into the mode of cytotoxic action of organotin compounds with protective 2,6-di-tert-butylphenol fragments

2015 ◽  
Vol 782 ◽  
pp. 96-102 ◽  
Author(s):  
E.R. Milaeva ◽  
D.B. Shpakovsky ◽  
Yu.A. Gracheva ◽  
T.A. Antonenko ◽  
D.I. Osolodkin ◽  
...  
Keyword(s):  
Organotin Compounds ◽  
Cytotoxic Action ◽  
Insight Into

scholarly journals Factors That Cause Trimethoprim Resistance in Streptococcus pyogenes

2014 ◽  
Vol 58 (4) ◽  
pp. 2281-2288 ◽  
Author(s):  
René Bergmann ◽  
Mark van der Linden ◽  
Gursharan S. Chhatwal ◽  
D. Patric Nitsche-Schmitz
Keyword(s):  
Streptococcus Pneumoniae ◽  
Amino Acid ◽  
Nucleotide Sequence ◽  
Streptococcus Pyogenes ◽  
Dihydrofolate Reductase ◽  
Molecular Basis ◽  
Rapid Development ◽  
Antibiotic Agent ◽  
Content Type ◽  
Insight Into

ABSTRACTThe use of trimethoprim in treatment ofStreptococcus pyogenesinfections has long been discouraged because it has been widely believed that this pathogen is resistant to this antibiotic. To gain more insight into the extent and molecular basis of trimethoprim resistance inS. pyogenes, we tested isolates from India and Germany and sought the factors that conferred the resistance. Resistant isolates were identified in tests for trimethoprim or trimethoprim-sulfamethoxazole (SXT) susceptibility. Resistant isolates were screened for the known horizontally transferable trimethoprim-insensitive dihydrofolate reductase (dfr) genesdfrG,dfrF,dfrA,dfrD, anddfrK. The nucleotide sequence of the intrinsicdfrgene was determined for resistant isolates lacking the horizontally transferable genes. Based on tentative criteria, 69 out of 268 isolates (25.7%) from India were resistant to trimethoprim. Occurring in 42 of the 69 resistant isolates (60.9%),dfrFappeared more frequently thandfrG(23 isolates; 33.3%) in India. ThedfrFgene was also present in a collection of SXT-resistant isolates from Germany, in which it was the only detected trimethoprim resistance factor. ThedfrFgene caused resistance in 4 out of 5 trimethoprim-resistant isolates from the German collection. An amino acid substitution in the intrinsic dihydrofolate reductase known from trimethoprim-resistantStreptococcus pneumoniaeconferred resistance toS. pyogenesisolates ofemmtype 102.2, which lacked other aforementioneddfrgenes. Trimethoprim may be more useful in treatment ofS. pyogenesinfections than previously thought. However, the factors described herein may lead to the rapid development and spread of resistance ofS. pyogenesto this antibiotic agent.

Calibration problems in hydrogen luminosities

1966 ◽  
Vol 24 ◽  
pp. 322-330
Author(s):  
A. Beer
Keyword(s):  
Galactic Structure ◽  
B Stars ◽  
Insight Into

The investigations which I should like to summarize in this paper concern recent photo-electric luminosity determinations of O and B stars. Their final aim has been the derivation of new stellar distances, and some insight into certain patterns of galactic structure.

Stochasting modeling of planetary ring systems

1984 ◽  
Vol 75 ◽  
pp. 461-469 ◽  
Author(s):  
Robert W. Hart
Keyword(s):  
Maximum Entropy ◽  
Ring System ◽  
The Sun ◽  
Ultimate State ◽  
Interparticle Interactions ◽  
Ring Systems ◽  
First Order ◽  
Planetary Ring ◽  
Insight Into

ABSTRACTThis paper models maximum entropy configurations of idealized gravitational ring systems. Such configurations are of interest because systems generally evolve toward an ultimate state of maximum randomness. For simplicity, attention is confined to ultimate states for which interparticle interactions are no longer of first order importance. The planets, in their orbits about the sun, are one example of such a ring system. The extent to which the present approximation yields insight into ring systems such as Saturn's is explored briefly.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

Sign in / Sign up

Export Citation Format

Share Document